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Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia

Lane, Emma L.; Björklund, Anders LU ; Dunnett, Stephen B. and Winkler, Christian (2010) In Progress in Brain Research 184. p.295-309
Abstract
The development of neural transplantation as a treatment for Parkinson's disease has been compromised by a lack of functional efficacy and the appearance of transplant-induced motor side-effects in some patients. Since the first reports of these graft-induced dyskinesias (GID), and the realization of their impact on the progress of the field, a great deal of experimental work has been performed to determine the underlying cause(s) of this problematic side-effect. In this review we describe the clinical phenomenon of GID, explore the different representations of GID in rodent models, and examine the various hypotheses that have been postulated to be the cause. Based on the available clinical and preclinical data we outline strategies to... (More)
The development of neural transplantation as a treatment for Parkinson's disease has been compromised by a lack of functional efficacy and the appearance of transplant-induced motor side-effects in some patients. Since the first reports of these graft-induced dyskinesias (GID), and the realization of their impact on the progress of the field, a great deal of experimental work has been performed to determine the underlying cause(s) of this problematic side-effect. In this review we describe the clinical phenomenon of GID, explore the different representations of GID in rodent models, and examine the various hypotheses that have been postulated to be the cause. Based on the available clinical and preclinical data we outline strategies to avoid GID in future clinical trials using fetal cell transplants or cell preparations derived from stem cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Parkinson's disease, Transplantation, Dopamine, Dyskinesia, Graft-induced dyskinesia, L-dopa-induced dyskinesia, Amphetamine-induced dyskinesia
in
Progress in Brain Research
volume
184
pages
295 - 309
publisher
Elsevier
external identifiers
  • wos:000287856300016
  • scopus:77957235017
ISSN
1875-7855
DOI
10.1016/S0079-6123(10)84015-4
language
English
LU publication?
yes
id
20758363-a591-4a31-b451-e6c108b489a2 (old id 1859404)
date added to LUP
2011-04-01 08:28:47
date last changed
2018-05-29 09:20:09
@article{20758363-a591-4a31-b451-e6c108b489a2,
  abstract     = {The development of neural transplantation as a treatment for Parkinson's disease has been compromised by a lack of functional efficacy and the appearance of transplant-induced motor side-effects in some patients. Since the first reports of these graft-induced dyskinesias (GID), and the realization of their impact on the progress of the field, a great deal of experimental work has been performed to determine the underlying cause(s) of this problematic side-effect. In this review we describe the clinical phenomenon of GID, explore the different representations of GID in rodent models, and examine the various hypotheses that have been postulated to be the cause. Based on the available clinical and preclinical data we outline strategies to avoid GID in future clinical trials using fetal cell transplants or cell preparations derived from stem cells.},
  author       = {Lane, Emma L. and Björklund, Anders and Dunnett, Stephen B. and Winkler, Christian},
  issn         = {1875-7855},
  keyword      = {Parkinson's disease,Transplantation,Dopamine,Dyskinesia,Graft-induced dyskinesia,L-dopa-induced dyskinesia,Amphetamine-induced dyskinesia},
  language     = {eng},
  pages        = {295--309},
  publisher    = {Elsevier},
  series       = {Progress in Brain Research},
  title        = {Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia},
  url          = {http://dx.doi.org/10.1016/S0079-6123(10)84015-4},
  volume       = {184},
  year         = {2010},
}