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Bioderived, chiral and stable 1-dimensional light-responsive nanostructures : Interconversion between tubules and twisted ribbons

Santilli, Andrea ; Lapi, Andrea ; Cautela, Jacopo LU ; D'Abramo, Marco ; Giuseppe Chen, Cheng ; Del Giudice, Alessandra LU orcid ; Sennato, Simona ; Belić, Domagoj LU ; Hugo Soto Tellini, Victor and Schillén, Karin LU orcid , et al. (2022) In Journal of Colloid and Interface Science 623. p.723-734
Abstract

HYPOTHESIS: Self-assembling molecular structures responding to light stimulus are appealing for applications as sensing and drug delivery. Supramolecular nanotubes have a relevant potential in nanotechnology as they can be used to encapsulate different loads like drugs, biological macromolecules, and nanomaterials. In addition, they are suitable elements for novel supracolloidal materials. Structural responses of supramolecular nanotubes to non-invasive stimuli are very much desired to enable controlled release of the encapsulated guests and to provide these recently developed new materials with an external trigger. Here, we describe the formation of well-defined, single wall tubules that interconvert into twisted ribbons upon UV-light... (More)

HYPOTHESIS: Self-assembling molecular structures responding to light stimulus are appealing for applications as sensing and drug delivery. Supramolecular nanotubes have a relevant potential in nanotechnology as they can be used to encapsulate different loads like drugs, biological macromolecules, and nanomaterials. In addition, they are suitable elements for novel supracolloidal materials. Structural responses of supramolecular nanotubes to non-invasive stimuli are very much desired to enable controlled release of the encapsulated guests and to provide these recently developed new materials with an external trigger. Here, we describe the formation of well-defined, single wall tubules that interconvert into twisted ribbons upon UV-light exposure in aqueous environment. The structures are provided by self-assembly of an azobenzene substituted cholic acid, a biological surfactant belonging to the family of bile acids. The azobenzene group allows for the light responsiveness of the molecular packing. Concurrently the steroidal moieties assure both chiral features and extensive hydrophobic interactions for time and temperature resistant aggregates.

EXPERIMENTS: The molecular packing interconversion was followed by circular dichroism. Microscopy, small angle X-ray scattering and light scattering measurements demonstrated the drastic morphological variation upon irradiation. A model of the molecular arrangement within the tubular walls was suggested based on the circular dichroism spectra simulation.

FINDINGS: Innovatively, the molecular design reported in our work allows for encoding in the same light responsive system multiple desirable features (e.g. bio-origin, temperature resistance and chirality of the aggregates). Such combination of properties, never reported before for a single molecule, might be relevant for the realization of robust, stimuli-responsive bio-vectors.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Colloid and Interface Science
volume
623
pages
12 pages
publisher
Elsevier
external identifiers
  • pmid:35605451
  • scopus:85130845342
ISSN
0021-9797
DOI
10.1016/j.jcis.2022.05.025
language
English
LU publication?
yes
additional info
Copyright © 2022 Elsevier Inc. All rights reserved.
id
18651bfb-ce8a-48f2-bbc2-18cbeeb4a5a0
date added to LUP
2022-05-24 16:07:50
date last changed
2024-06-13 17:30:41
@article{18651bfb-ce8a-48f2-bbc2-18cbeeb4a5a0,
  abstract     = {{<p>HYPOTHESIS: Self-assembling molecular structures responding to light stimulus are appealing for applications as sensing and drug delivery. Supramolecular nanotubes have a relevant potential in nanotechnology as they can be used to encapsulate different loads like drugs, biological macromolecules, and nanomaterials. In addition, they are suitable elements for novel supracolloidal materials. Structural responses of supramolecular nanotubes to non-invasive stimuli are very much desired to enable controlled release of the encapsulated guests and to provide these recently developed new materials with an external trigger. Here, we describe the formation of well-defined, single wall tubules that interconvert into twisted ribbons upon UV-light exposure in aqueous environment. The structures are provided by self-assembly of an azobenzene substituted cholic acid, a biological surfactant belonging to the family of bile acids. The azobenzene group allows for the light responsiveness of the molecular packing. Concurrently the steroidal moieties assure both chiral features and extensive hydrophobic interactions for time and temperature resistant aggregates.</p><p>EXPERIMENTS: The molecular packing interconversion was followed by circular dichroism. Microscopy, small angle X-ray scattering and light scattering measurements demonstrated the drastic morphological variation upon irradiation. A model of the molecular arrangement within the tubular walls was suggested based on the circular dichroism spectra simulation.</p><p>FINDINGS: Innovatively, the molecular design reported in our work allows for encoding in the same light responsive system multiple desirable features (e.g. bio-origin, temperature resistance and chirality of the aggregates). Such combination of properties, never reported before for a single molecule, might be relevant for the realization of robust, stimuli-responsive bio-vectors.</p>}},
  author       = {{Santilli, Andrea and Lapi, Andrea and Cautela, Jacopo and D'Abramo, Marco and Giuseppe Chen, Cheng and Del Giudice, Alessandra and Sennato, Simona and Belić, Domagoj and Hugo Soto Tellini, Victor and Schillén, Karin and di Gregorio, Maria Chiara and Galantini, Luciano}},
  issn         = {{0021-9797}},
  language     = {{eng}},
  pages        = {{723--734}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Colloid and Interface Science}},
  title        = {{Bioderived, chiral and stable 1-dimensional light-responsive nanostructures : Interconversion between tubules and twisted ribbons}},
  url          = {{http://dx.doi.org/10.1016/j.jcis.2022.05.025}},
  doi          = {{10.1016/j.jcis.2022.05.025}},
  volume       = {{623}},
  year         = {{2022}},
}