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Cerebrospinal fluid influx drives acute ischemic tissue swelling

Mestre, Humberto ; Du, Ting ; Sweeney, Amanda M. ; Liu, Guojun ; Samson, Andrew J. ; Peng, Weiguo ; Mortensen, Kristian Nygaard ; Stæger, Frederik Filip ; Bork, Peter A.R. and Bashford, Logan , et al. (2020) In Science (New York, N.Y.) 367(6483).
Abstract

Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled... (More)

Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.

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publishing date
type
Contribution to journal
publication status
published
in
Science (New York, N.Y.)
volume
367
issue
6483
article number
eaax7171
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • scopus:85081917924
  • pmid:32001524
  • scopus:85079726099
ISSN
1095-9203
DOI
10.1126/science.aax7171
language
English
LU publication?
no
additional info
Publisher Copyright: © 2020 American Association for the Advancement of Science. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
id
1865cd48-a1c7-4d60-820d-e504632f36d2
date added to LUP
2021-03-19 21:21:01
date last changed
2024-04-18 03:48:34
@article{1865cd48-a1c7-4d60-820d-e504632f36d2,
  abstract     = {{<p>Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.</p>}},
  author       = {{Mestre, Humberto and Du, Ting and Sweeney, Amanda M. and Liu, Guojun and Samson, Andrew J. and Peng, Weiguo and Mortensen, Kristian Nygaard and Stæger, Frederik Filip and Bork, Peter A.R. and Bashford, Logan and Toro, Edna R. and Tithof, Jeffrey and Kelley, Douglas H. and Thomas, John H. and Hjorth, Poul G. and Martens, Erik A. and Mehta, Rupal I. and Solis, Orestes and Blinder, Pablo and Kleinfeld, David and Hirase, Hajime and Mori, Yuki and Nedergaard, Maiken}},
  issn         = {{1095-9203}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6483}},
  publisher    = {{American Association for the Advancement of Science (AAAS)}},
  series       = {{Science (New York, N.Y.)}},
  title        = {{Cerebrospinal fluid influx drives acute ischemic tissue swelling}},
  url          = {{http://dx.doi.org/10.1126/science.aax7171}},
  doi          = {{10.1126/science.aax7171}},
  volume       = {{367}},
  year         = {{2020}},
}