The CKD-EPI and MDRD equations to estimate GFR. Validation in the Swedish Lund-Malmo Study cohort
(2011) In Scandinavian Journal of Clinical & Laboratory Investigation 71(2). p.129-138- Abstract
- Objective. To compare the recently developed CKD-EPI equation to estimate GFR in adult Swedish-Caucasians with the MDRD equation. Material and methods. Swedish-Caucasians (N = 850, 376 females; median age 60, range 5-95 years) referred for plasma iohexol-clearance (median 55, range 5-223 mL/min/1.73 m(2)) constituted the Lund-Malmo Study cohort. Bias, precision (interquartile range, IQR, of the differences between estimated and measured GFR), accuracy expressed as percentage of estimates +/- 10% (P-10) and +/- 30% (P-30) of measured GFR, and classification ability for five GFR stages < 15, 15-29, 30-59, 60-89 and >= 90 mL/min/1.73 m(2) were compared. Results. Overall there were no important differences between the equations;... (More)
- Objective. To compare the recently developed CKD-EPI equation to estimate GFR in adult Swedish-Caucasians with the MDRD equation. Material and methods. Swedish-Caucasians (N = 850, 376 females; median age 60, range 5-95 years) referred for plasma iohexol-clearance (median 55, range 5-223 mL/min/1.73 m(2)) constituted the Lund-Malmo Study cohort. Bias, precision (interquartile range, IQR, of the differences between estimated and measured GFR), accuracy expressed as percentage of estimates +/- 10% (P-10) and +/- 30% (P-30) of measured GFR, and classification ability for five GFR stages < 15, 15-29, 30-59, 60-89 and >= 90 mL/min/1.73 m(2) were compared. Results. Overall there were no important differences between the equations; CKD-EPI/MDRD median values of bias +5.4%/+3.4%, IQR both 14 mL/min/1.73 m(2), P-10 36%/34%, P-30 both 80%, and correctly classified GFR stages 68%/67%. P-30 for the CKD-EPI equation was substantially higher than for MDRD at GFR >= 90 mL/min/1.73 m(2) (93% versus 79%). The MDRD equation performed better in the GFR interval 30-89 mL/min/1.73 m(2), while accuracy was limited for both equations at GFR < 30 mL/min/1.73 m(2) (P-30 < 75% in both females and males). The CKD-EPI/MDRD equations caused a +22%/ +14% bias in the 18-39 year interval and the MDRD equation a + 18% bias >= 80 years. Both equations performed poorly in males with BMI < 20 kg/m(2) (CKD-EPI/MDRD median bias +36%/46%). Conclusion. Overall the recently developed CKD-EPI equation performed well but was not superior to the MDRD equation. The CKD-EPI equation may be preferred in screenings of general populations and in the elderly. None of the equations appeared reliable among patients with markedly decreased GFR, young adults and underweight males. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1868216
- author
- Nyman, Ulf ; Grubb, Anders LU ; Sterner, Gunnar LU and Björk, Jonas LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Kidney disease, kidney function tests, glomerular filtration rate, renal insufficiency
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 71
- issue
- 2
- pages
- 129 - 138
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000288126400010
- scopus:79952424055
- ISSN
- 1502-7686
- DOI
- 10.3109/00365513.2010.543143
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Occupational and Environmental Medicine (013078001), Emergency medicine/Medicine/Surgery (013240200), Division of Clinical Chemistry and Pharmacology (013250300)
- id
- a96e50c1-bc41-4054-9f10-31437b90771e (old id 1868216)
- date added to LUP
- 2016-04-01 13:55:55
- date last changed
- 2023-02-13 19:51:07
@article{a96e50c1-bc41-4054-9f10-31437b90771e, abstract = {{Objective. To compare the recently developed CKD-EPI equation to estimate GFR in adult Swedish-Caucasians with the MDRD equation. Material and methods. Swedish-Caucasians (N = 850, 376 females; median age 60, range 5-95 years) referred for plasma iohexol-clearance (median 55, range 5-223 mL/min/1.73 m(2)) constituted the Lund-Malmo Study cohort. Bias, precision (interquartile range, IQR, of the differences between estimated and measured GFR), accuracy expressed as percentage of estimates +/- 10% (P-10) and +/- 30% (P-30) of measured GFR, and classification ability for five GFR stages < 15, 15-29, 30-59, 60-89 and >= 90 mL/min/1.73 m(2) were compared. Results. Overall there were no important differences between the equations; CKD-EPI/MDRD median values of bias +5.4%/+3.4%, IQR both 14 mL/min/1.73 m(2), P-10 36%/34%, P-30 both 80%, and correctly classified GFR stages 68%/67%. P-30 for the CKD-EPI equation was substantially higher than for MDRD at GFR >= 90 mL/min/1.73 m(2) (93% versus 79%). The MDRD equation performed better in the GFR interval 30-89 mL/min/1.73 m(2), while accuracy was limited for both equations at GFR < 30 mL/min/1.73 m(2) (P-30 < 75% in both females and males). The CKD-EPI/MDRD equations caused a +22%/ +14% bias in the 18-39 year interval and the MDRD equation a + 18% bias >= 80 years. Both equations performed poorly in males with BMI < 20 kg/m(2) (CKD-EPI/MDRD median bias +36%/46%). Conclusion. Overall the recently developed CKD-EPI equation performed well but was not superior to the MDRD equation. The CKD-EPI equation may be preferred in screenings of general populations and in the elderly. None of the equations appeared reliable among patients with markedly decreased GFR, young adults and underweight males.}}, author = {{Nyman, Ulf and Grubb, Anders and Sterner, Gunnar and Björk, Jonas}}, issn = {{1502-7686}}, keywords = {{Kidney disease; kidney function tests; glomerular filtration rate; renal insufficiency}}, language = {{eng}}, number = {{2}}, pages = {{129--138}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Clinical & Laboratory Investigation}}, title = {{The CKD-EPI and MDRD equations to estimate GFR. Validation in the Swedish Lund-Malmo Study cohort}}, url = {{http://dx.doi.org/10.3109/00365513.2010.543143}}, doi = {{10.3109/00365513.2010.543143}}, volume = {{71}}, year = {{2011}}, }