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Increased markers of inflammation and endothelial dysfunction in patients with mild primary hyperparathyroidism

Almqvist, Erik G.; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU and Svensson, Johan (2011) In Scandinavian Journal of Clinical & Laboratory Investigation 71(2). p.139-144
Abstract
Objectives: The association between primary hyperparathyroidism (PHPT) and cardiovascular disease is incompletely understood. The aims of this study were to evaluate how cardiac function and markers of inflammation and endothelial dysfunction correlate in patients with mild PHPT, and how these markers are influenced by surgical cure of the parathyroid disease (PTX). Material and methods: Forty-five patients with PHPT were examined before and 1 year after PTX. Serum/plasma concentrations of calcium, PTH, highly sensitive C-reactive protein (CRP), interleukin-6 (IL-6), vascular adhesion molecule-1 (VCAM1), E-selectin, and NT-proBNP were measured as well as erythrocyte sedimentation rate (ESR) and creatinine clearance. Cardiac function was... (More)
Objectives: The association between primary hyperparathyroidism (PHPT) and cardiovascular disease is incompletely understood. The aims of this study were to evaluate how cardiac function and markers of inflammation and endothelial dysfunction correlate in patients with mild PHPT, and how these markers are influenced by surgical cure of the parathyroid disease (PTX). Material and methods: Forty-five patients with PHPT were examined before and 1 year after PTX. Serum/plasma concentrations of calcium, PTH, highly sensitive C-reactive protein (CRP), interleukin-6 (IL-6), vascular adhesion molecule-1 (VCAM1), E-selectin, and NT-proBNP were measured as well as erythrocyte sedimentation rate (ESR) and creatinine clearance. Cardiac function was evaluated by equilibrium radionuclide angiography. Results: The baseline serum level of IL-6 correlated negatively with baseline parameters of cardiac function (exercise capacity, p < 0.001, left ventricular ejection fraction at exercise, p < 0.01). The mean serum concentrations of IL-6 and CRP and the ESR had increased 1 year after PTX (p < 0.001, p < 0.01, and p < 0.001, respectively) in parallel with a decrease in cardiac function and an increase in circulating NT-proBNP. The mean serum level of VCAM1 was above the upper normal range at baseline and had not changed significantly 1 year after PTX. Conclusion: Patients with mild PHPT and normal renal function displayed signs of subclinical inflammation and endothelial dysfunction. One year after PTX, the inflammatory markers were increased in parallel with a subclinical decrease in cardiac function. Further studies are warranted to clarify the natural course and clinical implications of these changes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-reactive protein, E-selectin, interleukin-6, NT-proBNP, vascular cell, adhesion molecule-1
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
71
issue
2
pages
139 - 144
publisher
Informa Healthcare
external identifiers
  • wos:000288126400011
  • scopus:79952376334
ISSN
1502-7686
DOI
10.3109/00365513.2010.543694
language
English
LU publication?
yes
id
e59ab31b-ed27-4628-99c2-4a51a476254b (old id 1868222)
date added to LUP
2011-04-04 10:26:14
date last changed
2017-07-09 03:52:54
@article{e59ab31b-ed27-4628-99c2-4a51a476254b,
  abstract     = {Objectives: The association between primary hyperparathyroidism (PHPT) and cardiovascular disease is incompletely understood. The aims of this study were to evaluate how cardiac function and markers of inflammation and endothelial dysfunction correlate in patients with mild PHPT, and how these markers are influenced by surgical cure of the parathyroid disease (PTX). Material and methods: Forty-five patients with PHPT were examined before and 1 year after PTX. Serum/plasma concentrations of calcium, PTH, highly sensitive C-reactive protein (CRP), interleukin-6 (IL-6), vascular adhesion molecule-1 (VCAM1), E-selectin, and NT-proBNP were measured as well as erythrocyte sedimentation rate (ESR) and creatinine clearance. Cardiac function was evaluated by equilibrium radionuclide angiography. Results: The baseline serum level of IL-6 correlated negatively with baseline parameters of cardiac function (exercise capacity, p &lt; 0.001, left ventricular ejection fraction at exercise, p &lt; 0.01). The mean serum concentrations of IL-6 and CRP and the ESR had increased 1 year after PTX (p &lt; 0.001, p &lt; 0.01, and p &lt; 0.001, respectively) in parallel with a decrease in cardiac function and an increase in circulating NT-proBNP. The mean serum level of VCAM1 was above the upper normal range at baseline and had not changed significantly 1 year after PTX. Conclusion: Patients with mild PHPT and normal renal function displayed signs of subclinical inflammation and endothelial dysfunction. One year after PTX, the inflammatory markers were increased in parallel with a subclinical decrease in cardiac function. Further studies are warranted to clarify the natural course and clinical implications of these changes.},
  author       = {Almqvist, Erik G. and Bondeson, Anne-Greth and Bondeson, Lennart and Svensson, Johan},
  issn         = {1502-7686},
  keyword      = {C-reactive protein,E-selectin,interleukin-6,NT-proBNP,vascular cell,adhesion molecule-1},
  language     = {eng},
  number       = {2},
  pages        = {139--144},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Increased markers of inflammation and endothelial dysfunction in patients with mild primary hyperparathyroidism},
  url          = {http://dx.doi.org/10.3109/00365513.2010.543694},
  volume       = {71},
  year         = {2011},
}