Stability of diphenylalanine peptide nanotubes in solution
(2011) In Nanoscale 3(3). p.994-998- Abstract
- Over the last couple of years, self-organizing nanotubes based on the dipeptide diphenylalanine have received much attention, mainly as possible building blocks for the next generation of biosensors and as drug delivery systems. One of the main reasons for this large interest is that these peptide nanotubes are believed to be very stable both thermally and chemically. Previously, the chemical and thermal stability of self-organizing structures has been investigated after the evaporation of the solvent. However, it was recently discovered that the stability of the structures differed significantly when the tubes were in solution. It has been shown that, in solution, the peptide nanotubes can easily be dissolved in several solvents including... (More)
- Over the last couple of years, self-organizing nanotubes based on the dipeptide diphenylalanine have received much attention, mainly as possible building blocks for the next generation of biosensors and as drug delivery systems. One of the main reasons for this large interest is that these peptide nanotubes are believed to be very stable both thermally and chemically. Previously, the chemical and thermal stability of self-organizing structures has been investigated after the evaporation of the solvent. However, it was recently discovered that the stability of the structures differed significantly when the tubes were in solution. It has been shown that, in solution, the peptide nanotubes can easily be dissolved in several solvents including water. It is therefore of critical importance that the stability of the nanotubes in solution and not after solvent evaporation be investigated prior to applications in which the nanotube will be submerged in liquid. The present article reports results demonstrating the instability and suggests a possible approach to a stabilization procedure, which drastically improves the stability of the formed structures. The results presented herein provide new information regarding the stability of self-organizing diphenylalanine nanotubes in solution. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1868306
- author
- Andersen, Karsten Brandt ; Castillo-Leon, Jaime ; Hedström, Martin LU and Svendsen, Winnie Edith
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nanoscale
- volume
- 3
- issue
- 3
- pages
- 994 - 998
- publisher
- Royal Society of Chemistry
- external identifiers
-
- wos:000288218300032
- scopus:79952676736
- pmid:21132174
- ISSN
- 2040-3372
- DOI
- 10.1039/c0nr00734j
- language
- English
- LU publication?
- yes
- id
- fa6945d0-0695-4255-ad25-e943940c0b49 (old id 1868306)
- date added to LUP
- 2016-04-01 09:56:04
- date last changed
- 2022-01-25 18:04:10
@article{fa6945d0-0695-4255-ad25-e943940c0b49,
abstract = {{Over the last couple of years, self-organizing nanotubes based on the dipeptide diphenylalanine have received much attention, mainly as possible building blocks for the next generation of biosensors and as drug delivery systems. One of the main reasons for this large interest is that these peptide nanotubes are believed to be very stable both thermally and chemically. Previously, the chemical and thermal stability of self-organizing structures has been investigated after the evaporation of the solvent. However, it was recently discovered that the stability of the structures differed significantly when the tubes were in solution. It has been shown that, in solution, the peptide nanotubes can easily be dissolved in several solvents including water. It is therefore of critical importance that the stability of the nanotubes in solution and not after solvent evaporation be investigated prior to applications in which the nanotube will be submerged in liquid. The present article reports results demonstrating the instability and suggests a possible approach to a stabilization procedure, which drastically improves the stability of the formed structures. The results presented herein provide new information regarding the stability of self-organizing diphenylalanine nanotubes in solution.}},
author = {{Andersen, Karsten Brandt and Castillo-Leon, Jaime and Hedström, Martin and Svendsen, Winnie Edith}},
issn = {{2040-3372}},
language = {{eng}},
number = {{3}},
pages = {{994--998}},
publisher = {{Royal Society of Chemistry}},
series = {{Nanoscale}},
title = {{Stability of diphenylalanine peptide nanotubes in solution}},
url = {{http://dx.doi.org/10.1039/c0nr00734j}},
doi = {{10.1039/c0nr00734j}},
volume = {{3}},
year = {{2011}},
}