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The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance

Zhang, Lei; Qiao, Qing; Laatikainen, Tiina; Soderberg, Stefan; Jousilahti, Pekka; Onat, Altan; Nilsson, Peter LU and Tuomilehto, Jaakko (2011) In Diabetes Research and Clinical Practice 91(3). p.406-412
Abstract
Background: The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories. Methods: Data from six population-based prospective studies in Finland and Sweden, with 4818 men and 4269 women aged 25-89 years who were free of CHD and without a prior history of diabetes at baseline, were jointly analysed. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD incidence were estimated. Results: 457 participants developed CHD during follow-up of 10 years. The multivariate adjusted HRs (95% CIs) for CHD incidence were 1.39 (1.08-1.80), 0.57 (0.39-0.84), 1.21 (1.07-1.37), 1.56 (1.21-2.01) and 1.74 (1.34-2.26), respectively,... (More)
Background: The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories. Methods: Data from six population-based prospective studies in Finland and Sweden, with 4818 men and 4269 women aged 25-89 years who were free of CHD and without a prior history of diabetes at baseline, were jointly analysed. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD incidence were estimated. Results: 457 participants developed CHD during follow-up of 10 years. The multivariate adjusted HRs (95% CIs) for CHD incidence were 1.39 (1.08-1.80), 0.57 (0.39-0.84), 1.21 (1.07-1.37), 1.56 (1.21-2.01) and 1.74 (1.34-2.26), respectively, corresponding to a one unit increase in Z-scores of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-C and TC to HDL ratio, in people with newly diagnosed diabetes. The prediction was also significant in non-diabetic population except for TG in individuals with normoglycaemia and TG and HDL-C in those with isolated IFG. Conclusion: Adverse lipid profiles were related to increased CHD incidence in normoglycaemic, fasting hyperglycaemic and diabetic individuals, but not in people with IGT. The findings may imply considering different management strategies in people with fasting or post-load hyperglycaemia. (C) 2010 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Coronary heart disease, Lipid, Diabetes, Impaired glucose tolerance, Impaired fasting glucose
in
Diabetes Research and Clinical Practice
volume
91
issue
3
pages
406 - 412
publisher
Elsevier
external identifiers
  • wos:000288168800026
  • scopus:79952364677
ISSN
1872-8227
DOI
10.1016/j.diabres.2010.12.004
language
English
LU publication?
yes
id
c6c24743-6d87-4b39-b0e0-a2f041e7a15f (old id 1868521)
date added to LUP
2011-04-04 12:49:17
date last changed
2017-01-01 03:30:59
@article{c6c24743-6d87-4b39-b0e0-a2f041e7a15f,
  abstract     = {Background: The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories. Methods: Data from six population-based prospective studies in Finland and Sweden, with 4818 men and 4269 women aged 25-89 years who were free of CHD and without a prior history of diabetes at baseline, were jointly analysed. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD incidence were estimated. Results: 457 participants developed CHD during follow-up of 10 years. The multivariate adjusted HRs (95% CIs) for CHD incidence were 1.39 (1.08-1.80), 0.57 (0.39-0.84), 1.21 (1.07-1.37), 1.56 (1.21-2.01) and 1.74 (1.34-2.26), respectively, corresponding to a one unit increase in Z-scores of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-C and TC to HDL ratio, in people with newly diagnosed diabetes. The prediction was also significant in non-diabetic population except for TG in individuals with normoglycaemia and TG and HDL-C in those with isolated IFG. Conclusion: Adverse lipid profiles were related to increased CHD incidence in normoglycaemic, fasting hyperglycaemic and diabetic individuals, but not in people with IGT. The findings may imply considering different management strategies in people with fasting or post-load hyperglycaemia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Zhang, Lei and Qiao, Qing and Laatikainen, Tiina and Soderberg, Stefan and Jousilahti, Pekka and Onat, Altan and Nilsson, Peter and Tuomilehto, Jaakko},
  issn         = {1872-8227},
  keyword      = {Coronary heart disease,Lipid,Diabetes,Impaired glucose tolerance,Impaired fasting glucose},
  language     = {eng},
  number       = {3},
  pages        = {406--412},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance},
  url          = {http://dx.doi.org/10.1016/j.diabres.2010.12.004},
  volume       = {91},
  year         = {2011},
}