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Ischemia/reperfusion in rat: Antioxidative effects of enoant on EEG, oxidative stress and inflammation

Kara, Ihsan; Nurten, Asiye; Aydin, Makbule; Ozkok, Elif; Ozen, Ilknur LU ; Ozerman, Bilge; Tuna, Sevilcan and Karamursel, Sacit (2011) In Brain Injury 25(1). p.113-126
Abstract
Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results:... (More)
Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results: There were significant changes in EEG activity in groups treated with enoant either before or after ischemia when compared with their basal EEG values. TNF-alpha, IL-6 and IL-1 beta levels were significantly increased after I/R. GSH levels in group 3 treated with enoant in both pre- and post-ischemic periods were significantly increased and TBARS concentration was decreased compared with the ischemic group. Conclusion: The findings support that both pre-ischemic and post-ischemic administrations of enoant might produce neuroprotective action against cerebral ischemia. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
EEG, ischemia/reperfusion, oxidative stress, inflammation, polyphenols
in
Brain Injury
volume
25
issue
1
pages
113 - 126
publisher
Taylor & Francis
external identifiers
  • wos:000288101700012
  • scopus:78650208570
ISSN
1362-301X
DOI
10.3109/02699052.2010.531688
language
English
LU publication?
yes
id
3e9fe838-1d28-4bde-8121-0d865e22b479 (old id 1868604)
date added to LUP
2011-04-04 12:44:47
date last changed
2017-09-03 03:11:05
@article{3e9fe838-1d28-4bde-8121-0d865e22b479,
  abstract     = {Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results: There were significant changes in EEG activity in groups treated with enoant either before or after ischemia when compared with their basal EEG values. TNF-alpha, IL-6 and IL-1 beta levels were significantly increased after I/R. GSH levels in group 3 treated with enoant in both pre- and post-ischemic periods were significantly increased and TBARS concentration was decreased compared with the ischemic group. Conclusion: The findings support that both pre-ischemic and post-ischemic administrations of enoant might produce neuroprotective action against cerebral ischemia.},
  author       = {Kara, Ihsan and Nurten, Asiye and Aydin, Makbule and Ozkok, Elif and Ozen, Ilknur and Ozerman, Bilge and Tuna, Sevilcan and Karamursel, Sacit},
  issn         = {1362-301X},
  keyword      = {EEG,ischemia/reperfusion,oxidative stress,inflammation,polyphenols},
  language     = {eng},
  number       = {1},
  pages        = {113--126},
  publisher    = {Taylor & Francis},
  series       = {Brain Injury},
  title        = {Ischemia/reperfusion in rat: Antioxidative effects of enoant on EEG, oxidative stress and inflammation},
  url          = {http://dx.doi.org/10.3109/02699052.2010.531688},
  volume       = {25},
  year         = {2011},
}