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Ischemia/reperfusion in rat: Antioxidative effects of enoant on EEG, oxidative stress and inflammation

Kara, Ihsan ; Nurten, Asiye ; Aydin, Makbule ; Ozkok, Elif ; Ozen, Ilknur LU ; Ozerman, Bilge ; Tuna, Sevilcan and Karamursel, Sacit (2011) In Brain Injury 25(1). p.113-126
Abstract
Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results:... (More)
Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results: There were significant changes in EEG activity in groups treated with enoant either before or after ischemia when compared with their basal EEG values. TNF-alpha, IL-6 and IL-1 beta levels were significantly increased after I/R. GSH levels in group 3 treated with enoant in both pre- and post-ischemic periods were significantly increased and TBARS concentration was decreased compared with the ischemic group. Conclusion: The findings support that both pre-ischemic and post-ischemic administrations of enoant might produce neuroprotective action against cerebral ischemia. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
EEG, ischemia/reperfusion, oxidative stress, inflammation, polyphenols
in
Brain Injury
volume
25
issue
1
pages
113 - 126
publisher
Taylor & Francis
external identifiers
  • wos:000288101700012
  • scopus:78650208570
  • pmid:21117911
ISSN
1362-301X
DOI
10.3109/02699052.2010.531688
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
3e9fe838-1d28-4bde-8121-0d865e22b479 (old id 1868604)
date added to LUP
2016-04-01 10:11:53
date last changed
2022-01-25 20:48:11
@article{3e9fe838-1d28-4bde-8121-0d865e22b479,
  abstract     = {{Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation in ischemia/reperfusion (I/R) injury. Methods: Ischemia was induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 was the ischemic control group. Group 2 was treated with enoant of 1.25 g kg(-1) per day for 15 days after I/R. Group 3 received the same concentration of enoant as in group 2 for 15 days before and after I/R. Group 4 was the sham operation group. EEG activities were recorded and the levels of TNF-alpha, IL-1 beta and IL-6, TBARS and GSH were measured in the whole brain homogenate. Results: There were significant changes in EEG activity in groups treated with enoant either before or after ischemia when compared with their basal EEG values. TNF-alpha, IL-6 and IL-1 beta levels were significantly increased after I/R. GSH levels in group 3 treated with enoant in both pre- and post-ischemic periods were significantly increased and TBARS concentration was decreased compared with the ischemic group. Conclusion: The findings support that both pre-ischemic and post-ischemic administrations of enoant might produce neuroprotective action against cerebral ischemia.}},
  author       = {{Kara, Ihsan and Nurten, Asiye and Aydin, Makbule and Ozkok, Elif and Ozen, Ilknur and Ozerman, Bilge and Tuna, Sevilcan and Karamursel, Sacit}},
  issn         = {{1362-301X}},
  keywords     = {{EEG; ischemia/reperfusion; oxidative stress; inflammation; polyphenols}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{113--126}},
  publisher    = {{Taylor & Francis}},
  series       = {{Brain Injury}},
  title        = {{Ischemia/reperfusion in rat: Antioxidative effects of enoant on EEG, oxidative stress and inflammation}},
  url          = {{http://dx.doi.org/10.3109/02699052.2010.531688}},
  doi          = {{10.3109/02699052.2010.531688}},
  volume       = {{25}},
  year         = {{2011}},
}