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Metabolic syndrome and risk of bladder cancer: prospective cohort study in the metabolic syndrome and cancer project (Me-Can)

Haggstrom, Christel; Stocks, Tanja; Rapp, Kilian; Bjorge, Tone; Lindkvist, Bjorn; Concin, Hans; Engeland, Anders; Manjer, Jonas LU ; Ulmer, Hanno and Selmer, Randi, et al. (2011) In International Journal of Cancer 128(8). p.1890-1898
Abstract
There are little data on the putative association between factors in the metabolic syndrome (MetS) and risk of bladder cancer. In the Metabolic Syndrome and Cancer project (Me-Can), measurements of height, weight, blood pressure and circulating levels of glucose, cholesterol, and triglycerides had been collected from 578,700 subjects in cohorts in Norway, Austria, and Sweden. We used Cox proportional hazard models to calculate relative risks (RRs) of bladder cancer by exposures divided into quintiles, in categories according to the World Health Organisation (WHO) and as a continuous standardized variable (z-score with mean = 0 and standard deviation = 1) for each separate component and its standardized sum, a composite MetS score. RRs were... (More)
There are little data on the putative association between factors in the metabolic syndrome (MetS) and risk of bladder cancer. In the Metabolic Syndrome and Cancer project (Me-Can), measurements of height, weight, blood pressure and circulating levels of glucose, cholesterol, and triglycerides had been collected from 578,700 subjects in cohorts in Norway, Austria, and Sweden. We used Cox proportional hazard models to calculate relative risks (RRs) of bladder cancer by exposures divided into quintiles, in categories according to the World Health Organisation (WHO) and as a continuous standardized variable (z-score with mean = 0 and standard deviation = 1) for each separate component and its standardized sum, a composite MetS score. RRs were corrected for random error in measurements. During a mean follow-up of 11.7 years (SD = 7.6), 1,587 men and 327 women were diagnosed with bladder cancer. Significant associations with risk were found among men per one unit increment of z-score for blood pressure, RR 5 1.13 (95% CI 1.03-1.25), and the composite MetS score, RR = 1.10 (95% CI 1.01-1.18). Among women, glucose was nonsignificantly associated with risk, RR = 1.41 (95% CI 0.97-2.06). No statistically significant interactions were found between the components in the MetS in relation to bladder cancer risk. Hypertension and a composite MetS score were significantly but modestly associated with an increased risk of bladder cancer among men and elevated glucose was associated with a nonsignificant increase in risk among women. Epidemiology (Less)
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publication status
published
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keywords
epidemiology, bladder cancer, metabolic syndrome, cohort study
in
International Journal of Cancer
volume
128
issue
8
pages
1890 - 1898
publisher
John Wiley & Sons
external identifiers
  • wos:000288037400015
  • scopus:79951961947
ISSN
0020-7136
DOI
10.1002/ijc.25521
language
English
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yes
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b3cf2fda-611b-4800-b0d8-69718fb06703 (old id 1869259)
date added to LUP
2011-04-04 09:19:00
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2017-05-28 03:07:30
@article{b3cf2fda-611b-4800-b0d8-69718fb06703,
  abstract     = {There are little data on the putative association between factors in the metabolic syndrome (MetS) and risk of bladder cancer. In the Metabolic Syndrome and Cancer project (Me-Can), measurements of height, weight, blood pressure and circulating levels of glucose, cholesterol, and triglycerides had been collected from 578,700 subjects in cohorts in Norway, Austria, and Sweden. We used Cox proportional hazard models to calculate relative risks (RRs) of bladder cancer by exposures divided into quintiles, in categories according to the World Health Organisation (WHO) and as a continuous standardized variable (z-score with mean = 0 and standard deviation = 1) for each separate component and its standardized sum, a composite MetS score. RRs were corrected for random error in measurements. During a mean follow-up of 11.7 years (SD = 7.6), 1,587 men and 327 women were diagnosed with bladder cancer. Significant associations with risk were found among men per one unit increment of z-score for blood pressure, RR 5 1.13 (95% CI 1.03-1.25), and the composite MetS score, RR = 1.10 (95% CI 1.01-1.18). Among women, glucose was nonsignificantly associated with risk, RR = 1.41 (95% CI 0.97-2.06). No statistically significant interactions were found between the components in the MetS in relation to bladder cancer risk. Hypertension and a composite MetS score were significantly but modestly associated with an increased risk of bladder cancer among men and elevated glucose was associated with a nonsignificant increase in risk among women. Epidemiology},
  author       = {Haggstrom, Christel and Stocks, Tanja and Rapp, Kilian and Bjorge, Tone and Lindkvist, Bjorn and Concin, Hans and Engeland, Anders and Manjer, Jonas and Ulmer, Hanno and Selmer, Randi and Tretli, Steinar and Hallmans, Goran and Jonsson, Hakan and Stattin, Par},
  issn         = {0020-7136},
  keyword      = {epidemiology,bladder cancer,metabolic syndrome,cohort study},
  language     = {eng},
  number       = {8},
  pages        = {1890--1898},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Metabolic syndrome and risk of bladder cancer: prospective cohort study in the metabolic syndrome and cancer project (Me-Can)},
  url          = {http://dx.doi.org/10.1002/ijc.25521},
  volume       = {128},
  year         = {2011},
}