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Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people

Yang, Zhen; Wen, Jie; Tao, Xiaoming; Lu, Bin; Du, Yanping; Wang, Mei; Wang, Xuanchun; Zhang, Weiwei; Gong, Wei and Ling, Charlotte LU , et al. (2011) In Molecular Biology Reports 38(2). p.1145-1150
Abstract
Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis IA degrees, 90 with steatosis hepatis IIA degrees and 28 with steatosis hepatis IIIA degrees) and 467 controls were genotyped by using... (More)
Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis IA degrees, 90 with steatosis hepatis IIA degrees and 28 with steatosis hepatis IIIA degrees) and 467 controls were genotyped by using TaqMan allelic discrimination assays. We confirmed the association of GCKR rs780094 with NAFLD in Chinese people (OR = 1.607, 95% CI 1.139-2.271, P ([dom]) = 7.2 x 10(-3)). In this study, polymorphism in GCKR rs780094 was not significantly associated with the degree of fatty infiltration of the liver. In addition, the T-allele of GCKR rs780094 was significantly associated with increasing fasting triglyceride (P ([add]) = 3.8 x 10(-4)) and CRP (P ([add]) = 2.9 x 10(-4)) concentrations after adjusting for age, gender, and BMI. The association with NAFLD remained significant after adjustment for triglyceride, while adjustment for CRP abolished the association. Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people. The effect of genotype on NAFLD is probably mediated through chronic low-grade systemic inflammation rather than through dislipidemia. (Less)
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organization
publishing date
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Contribution to journal
publication status
published
subject
keywords
GCKR, Polymorphism, Non-alcoholic fatty liver disease, CRP, Triglyceride
in
Molecular Biology Reports
volume
38
issue
2
pages
1145 - 1150
publisher
Springer
external identifiers
  • wos:000286472600057
  • scopus:79951575771
ISSN
0301-4851
DOI
10.1007/s11033-010-0212-1
language
English
LU publication?
yes
id
92f04829-f329-44f5-9956-f0760cf9bba6 (old id 1872626)
date added to LUP
2011-04-04 08:05:35
date last changed
2017-09-03 04:04:19
@article{92f04829-f329-44f5-9956-f0760cf9bba6,
  abstract     = {Recent genome-wide association studies reported that GCKR rs780094 polymorphism is associated with elevated fasting serum triglyceride levels and elevated levels of C-reactive protein (CRP). There are a ample of data on the association between circulating triglyceride, CRP concentrations and risk of non-alcoholic fatty liver (NAFLD). To determine whether the GCKR rs780094 polymorphism contributes to the development of non-alcoholic fatty liver, a case-control study was performed in 903 Chinese subjects. Among study population, 436 patients with B-mode ultrasound-proven NAFLD (318 with steatosis hepatis IA degrees, 90 with steatosis hepatis IIA degrees and 28 with steatosis hepatis IIIA degrees) and 467 controls were genotyped by using TaqMan allelic discrimination assays. We confirmed the association of GCKR rs780094 with NAFLD in Chinese people (OR = 1.607, 95% CI 1.139-2.271, P ([dom]) = 7.2 x 10(-3)). In this study, polymorphism in GCKR rs780094 was not significantly associated with the degree of fatty infiltration of the liver. In addition, the T-allele of GCKR rs780094 was significantly associated with increasing fasting triglyceride (P ([add]) = 3.8 x 10(-4)) and CRP (P ([add]) = 2.9 x 10(-4)) concentrations after adjusting for age, gender, and BMI. The association with NAFLD remained significant after adjustment for triglyceride, while adjustment for CRP abolished the association. Genetic variation in GCKR gene rs780094 polymorphism contributes to the risk of NAFLD in Chinese people. The effect of genotype on NAFLD is probably mediated through chronic low-grade systemic inflammation rather than through dislipidemia.},
  author       = {Yang, Zhen and Wen, Jie and Tao, Xiaoming and Lu, Bin and Du, Yanping and Wang, Mei and Wang, Xuanchun and Zhang, Weiwei and Gong, Wei and Ling, Charlotte and Wu, Songhua and Hu, Renming},
  issn         = {0301-4851},
  keyword      = {GCKR,Polymorphism,Non-alcoholic fatty liver disease,CRP,Triglyceride},
  language     = {eng},
  number       = {2},
  pages        = {1145--1150},
  publisher    = {Springer},
  series       = {Molecular Biology Reports},
  title        = {Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people},
  url          = {http://dx.doi.org/10.1007/s11033-010-0212-1},
  volume       = {38},
  year         = {2011},
}