Advanced

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

Lotvall, Jan; Akdis, Cezmi A.; Bacharier, Leonard B.; Bjermer, Leif LU ; Casale, Thomas B.; Custovic, Adnan; Lemanske, Robert F.; Wardlaw, Andrew J.; Wenzel, Sally E. and Greenberger, Paul A. (2011) In Journal of Allergy and Clinical Immunology 127(2). p.355-360
Abstract
It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of asthma and improving treatment and can explain the failure to identify consistent genetic and environmental correlations to asthma. Here we describe a hypothesis whereby the asthma syndrome is divided into distinct disease entities with specific mechanisms, which we have called "asthma endotypes.'' An "endotype'' is proposed to be a subtype of a condition defined by a distinct pathophysiological mechanism. Criteria for defining asthma endotypes on the basis of their... (More)
It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of asthma and improving treatment and can explain the failure to identify consistent genetic and environmental correlations to asthma. Here we describe a hypothesis whereby the asthma syndrome is divided into distinct disease entities with specific mechanisms, which we have called "asthma endotypes.'' An "endotype'' is proposed to be a subtype of a condition defined by a distinct pathophysiological mechanism. Criteria for defining asthma endotypes on the basis of their phenotypes and putative pathophysiology are suggested. Using these criteria, we identify several proposed asthma endotypes and propose how these new definitions can be used in clinical study design and drug development to target existing and novel therapies to patients most likely to benefit. This PRACTALL (PRACtical ALLergy) consensus report was produced by experts from the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. (J Allergy Clin Immunol 2011;127:355-60.) (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Asthma, endotype, phenotype, cluster analysis, pathophysiology, epidemiology
in
Journal of Allergy and Clinical Immunology
volume
127
issue
2
pages
355 - 360
publisher
Elsevier
external identifiers
  • wos:000286808000007
  • scopus:79551505136
ISSN
1097-6825
DOI
10.1016/j.jaci.2010.11.037
language
English
LU publication?
yes
id
59581d49-8d3a-4843-a897-c0c3c309b6ce (old id 1872802)
date added to LUP
2011-04-04 07:45:24
date last changed
2017-11-19 04:02:20
@article{59581d49-8d3a-4843-a897-c0c3c309b6ce,
  abstract     = {It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of asthma and improving treatment and can explain the failure to identify consistent genetic and environmental correlations to asthma. Here we describe a hypothesis whereby the asthma syndrome is divided into distinct disease entities with specific mechanisms, which we have called "asthma endotypes.'' An "endotype'' is proposed to be a subtype of a condition defined by a distinct pathophysiological mechanism. Criteria for defining asthma endotypes on the basis of their phenotypes and putative pathophysiology are suggested. Using these criteria, we identify several proposed asthma endotypes and propose how these new definitions can be used in clinical study design and drug development to target existing and novel therapies to patients most likely to benefit. This PRACTALL (PRACtical ALLergy) consensus report was produced by experts from the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. (J Allergy Clin Immunol 2011;127:355-60.)},
  author       = {Lotvall, Jan and Akdis, Cezmi A. and Bacharier, Leonard B. and Bjermer, Leif and Casale, Thomas B. and Custovic, Adnan and Lemanske, Robert F. and Wardlaw, Andrew J. and Wenzel, Sally E. and Greenberger, Paul A.},
  issn         = {1097-6825},
  keyword      = {Asthma,endotype,phenotype,cluster analysis,pathophysiology,epidemiology},
  language     = {eng},
  number       = {2},
  pages        = {355--360},
  publisher    = {Elsevier},
  series       = {Journal of Allergy and Clinical Immunology},
  title        = {Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome},
  url          = {http://dx.doi.org/10.1016/j.jaci.2010.11.037},
  volume       = {127},
  year         = {2011},
}