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Perinatal cerebral insults alter auditory event-related potentials

Leipala, Jaana A.; Partanen, Eino; Kushnerenko, Elena; Huotilainen, Minna and Fellman, Vineta LU (2011) In Early Human Development 87(2). p.89-95
Abstract
Background: Auditory event-related potentials (AERPs) can be used as indices of neural information processing. Altered AERPs have been reported in children and young adults with frontal lobe infarction. Aim: To test the hypothesis that perinatal brain injury affects cortical auditory processing. Methods: We assessed AERPs at term. 6 and 12 months of age in preterm infants [n = 9. median gestational age (GA) 27.9, range 23.9-30.0 wk], term infants with perinatal intracerebral hemorrhage (ICH) [n = 5, GA 40.3, range 37.4-42.3 wk], and term infants with perinatal asphyxia In [n = 4. GA 39.4. range 37.9-40.3 wk]. Healthy preterm (n = 16) and term infants (n = 22) served as controls. A harmonic tone of 500-Hz frequency was used as standard and... (More)
Background: Auditory event-related potentials (AERPs) can be used as indices of neural information processing. Altered AERPs have been reported in children and young adults with frontal lobe infarction. Aim: To test the hypothesis that perinatal brain injury affects cortical auditory processing. Methods: We assessed AERPs at term. 6 and 12 months of age in preterm infants [n = 9. median gestational age (GA) 27.9, range 23.9-30.0 wk], term infants with perinatal intracerebral hemorrhage (ICH) [n = 5, GA 40.3, range 37.4-42.3 wk], and term infants with perinatal asphyxia In [n = 4. GA 39.4. range 37.9-40.3 wk]. Healthy preterm (n = 16) and term infants (n = 22) served as controls. A harmonic tone of 500-Hz frequency was used as standard and of 750-Hz as deviant stimulus. Mean AERP amplitudes were calculated over 100 ms periods from 50 to 350 ms. The developmental outcome was followed until 2 years of age. Results: The term ICH (p = 0.012) and asphyxia (p = 0.0016) group had smaller or more negative responses to the deviant, resulting in smaller or more negative MMR amplitudes than those of the controls. The preterm ICH group did not differ significantly from their preterm born controls. MMR varied in all patient groups and was not associated with adverse outcome. Conclusion: AERP alterations suggest that perinatal cerebral insults affect cortical auditory processing. (C) 2010 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
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Contribution to journal
publication status
published
subject
keywords
Auditory event-related potentials, Preterm infants, Intracerebral, hemorrhage, Perinatal asphyxia, Mismatch negativity, Mismatch response, Auditory processing
in
Early Human Development
volume
87
issue
2
pages
89 - 95
publisher
Elsevier
external identifiers
  • wos:000287290700005
  • scopus:78751625621
ISSN
1872-6232
DOI
10.1016/j.earlhumdev.2010.11.009
language
English
LU publication?
yes
id
5321b798-741c-43c7-89dd-82543ab813f1 (old id 1876199)
date added to LUP
2011-04-01 12:18:52
date last changed
2017-11-12 03:48:21
@article{5321b798-741c-43c7-89dd-82543ab813f1,
  abstract     = {Background: Auditory event-related potentials (AERPs) can be used as indices of neural information processing. Altered AERPs have been reported in children and young adults with frontal lobe infarction. Aim: To test the hypothesis that perinatal brain injury affects cortical auditory processing. Methods: We assessed AERPs at term. 6 and 12 months of age in preterm infants [n = 9. median gestational age (GA) 27.9, range 23.9-30.0 wk], term infants with perinatal intracerebral hemorrhage (ICH) [n = 5, GA 40.3, range 37.4-42.3 wk], and term infants with perinatal asphyxia In [n = 4. GA 39.4. range 37.9-40.3 wk]. Healthy preterm (n = 16) and term infants (n = 22) served as controls. A harmonic tone of 500-Hz frequency was used as standard and of 750-Hz as deviant stimulus. Mean AERP amplitudes were calculated over 100 ms periods from 50 to 350 ms. The developmental outcome was followed until 2 years of age. Results: The term ICH (p = 0.012) and asphyxia (p = 0.0016) group had smaller or more negative responses to the deviant, resulting in smaller or more negative MMR amplitudes than those of the controls. The preterm ICH group did not differ significantly from their preterm born controls. MMR varied in all patient groups and was not associated with adverse outcome. Conclusion: AERP alterations suggest that perinatal cerebral insults affect cortical auditory processing. (C) 2010 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Leipala, Jaana A. and Partanen, Eino and Kushnerenko, Elena and Huotilainen, Minna and Fellman, Vineta},
  issn         = {1872-6232},
  keyword      = {Auditory event-related potentials,Preterm infants,Intracerebral,hemorrhage,Perinatal asphyxia,Mismatch negativity,Mismatch response,Auditory processing},
  language     = {eng},
  number       = {2},
  pages        = {89--95},
  publisher    = {Elsevier},
  series       = {Early Human Development},
  title        = {Perinatal cerebral insults alter auditory event-related potentials},
  url          = {http://dx.doi.org/10.1016/j.earlhumdev.2010.11.009},
  volume       = {87},
  year         = {2011},
}