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Sensor Array Composed of "Clicked" Individual Microcantilever Chips

Paoloni, Francois LU ; Kelling, Sven; Huang, Juzheng and Elliott, Stephen R. (2011) In Advanced Functional Materials 21(2). p.372-379
Abstract
A simple technique is described to functionalize a small library of microcantilever (MC) chips presenting varied headgroups. A generic azide monolayer, bound to the MC surface, can be coupled with various alkynes using efficient "click" chemistry. This method is compatible with many functional groups, and novel headgroups are introduced on the MC surface by means of alkynes synthesized via a one-step reaction. The surface "click" reaction reduces greatly the effort that would be required to synthesize and purify the corresponding functional thiols. This technique represents a convenient complementary tool for Phase-Shifting Interferometric Microscopy (PSIM) read-out that has been developed in our group. The affinity of these surface... (More)
A simple technique is described to functionalize a small library of microcantilever (MC) chips presenting varied headgroups. A generic azide monolayer, bound to the MC surface, can be coupled with various alkynes using efficient "click" chemistry. This method is compatible with many functional groups, and novel headgroups are introduced on the MC surface by means of alkynes synthesized via a one-step reaction. The surface "click" reaction reduces greatly the effort that would be required to synthesize and purify the corresponding functional thiols. This technique represents a convenient complementary tool for Phase-Shifting Interferometric Microscopy (PSIM) read-out that has been developed in our group. The affinity of these surface coatings towards different solvents can be estimated by measuring the deflection of the cantilevers. A proof-of-concept sensor composed of four individual MC chips presenting different headgroups can unambiguously discriminate the fingerprint response of a nerve-gas simulant from other solvent vapors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Advanced Functional Materials
volume
21
issue
2
pages
372 - 379
publisher
Wiley-VCH
external identifiers
  • wos:000285887100022
  • scopus:78650685664
ISSN
1616-3028
DOI
10.1002/adfm.201000729
language
English
LU publication?
yes
id
4602f838-98d0-4323-9b62-2c8011ae5227 (old id 1876859)
date added to LUP
2011-04-14 14:46:23
date last changed
2017-09-28 13:30:26
@article{4602f838-98d0-4323-9b62-2c8011ae5227,
  abstract     = {A simple technique is described to functionalize a small library of microcantilever (MC) chips presenting varied headgroups. A generic azide monolayer, bound to the MC surface, can be coupled with various alkynes using efficient "click" chemistry. This method is compatible with many functional groups, and novel headgroups are introduced on the MC surface by means of alkynes synthesized via a one-step reaction. The surface "click" reaction reduces greatly the effort that would be required to synthesize and purify the corresponding functional thiols. This technique represents a convenient complementary tool for Phase-Shifting Interferometric Microscopy (PSIM) read-out that has been developed in our group. The affinity of these surface coatings towards different solvents can be estimated by measuring the deflection of the cantilevers. A proof-of-concept sensor composed of four individual MC chips presenting different headgroups can unambiguously discriminate the fingerprint response of a nerve-gas simulant from other solvent vapors.},
  author       = {Paoloni, Francois and Kelling, Sven and Huang, Juzheng and Elliott, Stephen R.},
  issn         = {1616-3028},
  language     = {eng},
  number       = {2},
  pages        = {372--379},
  publisher    = {Wiley-VCH },
  series       = {Advanced Functional Materials},
  title        = {Sensor Array Composed of "Clicked" Individual Microcantilever Chips},
  url          = {http://dx.doi.org/10.1002/adfm.201000729},
  volume       = {21},
  year         = {2011},
}