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Troponin I and Creatine Kinase MB do not provide comparable information after PCI

Gustavsson, Carl Gunnar LU and Nilson, Margareta (2011) In Scandinavian Cardiovascular Journal 45(1). p.21-26
Abstract
Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99<SUth</SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels > three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was > 3x99%URL in 58/486 patients (12%) and cTnI > 3x99%URL in 292/487 patients (60%). cTnI was > 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range... (More)
Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99<SUth</SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels > three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was > 3x99%URL in 58/486 patients (12%) and cTnI > 3x99%URL in 292/487 patients (60%). cTnI was > 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range from 1x to 10x99%URL and those with CK-MB 1x to 10x99%URL. Conclusions. With the present quantification scales, infarction rate after PCI is > five-fold higher with cTnI than with CK-MB. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Angioplasty, CK-MB, creatine kinase, infarction, PCI troponin
in
Scandinavian Cardiovascular Journal
volume
45
issue
1
pages
21 - 26
publisher
Taylor & Francis
external identifiers
  • wos:000286827600003
  • scopus:79551528054
ISSN
1651-2006
DOI
10.3109/14017431.2010.536989
language
English
LU publication?
yes
id
e76afd05-361d-41a5-9346-815a14e2dde0 (old id 1876913)
date added to LUP
2011-04-01 10:55:17
date last changed
2017-01-01 05:35:56
@article{e76afd05-361d-41a5-9346-815a14e2dde0,
  abstract     = {Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99&lt;SUth&lt;/SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels &gt; three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was &gt; 3x99%URL in 58/486 patients (12%) and cTnI &gt; 3x99%URL in 292/487 patients (60%). cTnI was &gt; 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range from 1x to 10x99%URL and those with CK-MB 1x to 10x99%URL. Conclusions. With the present quantification scales, infarction rate after PCI is &gt; five-fold higher with cTnI than with CK-MB.},
  author       = {Gustavsson, Carl Gunnar and Nilson, Margareta},
  issn         = {1651-2006},
  keyword      = {Angioplasty,CK-MB,creatine kinase,infarction,PCI troponin},
  language     = {eng},
  number       = {1},
  pages        = {21--26},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {Troponin I and Creatine Kinase MB do not provide comparable information after PCI},
  url          = {http://dx.doi.org/10.3109/14017431.2010.536989},
  volume       = {45},
  year         = {2011},
}