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Troponin I and Creatine Kinase MB do not provide comparable information after PCI

Gustavsson, Carl Gunnar LU and Nilson, Margareta (2011) In Scandinavian Cardiovascular Journal 45(1). p.21-26
Abstract
Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99<SUth</SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels > three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was > 3x99%URL in 58/486 patients (12%) and cTnI > 3x99%URL in 292/487 patients (60%). cTnI was > 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range... (More)
Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99<SUth</SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels > three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was > 3x99%URL in 58/486 patients (12%) and cTnI > 3x99%URL in 292/487 patients (60%). cTnI was > 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range from 1x to 10x99%URL and those with CK-MB 1x to 10x99%URL. Conclusions. With the present quantification scales, infarction rate after PCI is > five-fold higher with cTnI than with CK-MB. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Angioplasty, CK-MB, creatine kinase, infarction, PCI troponin
in
Scandinavian Cardiovascular Journal
volume
45
issue
1
pages
21 - 26
publisher
Taylor & Francis
external identifiers
  • wos:000286827600003
  • scopus:79551528054
  • pmid:21114454
ISSN
1651-2006
DOI
10.3109/14017431.2010.536989
language
English
LU publication?
yes
id
e76afd05-361d-41a5-9346-815a14e2dde0 (old id 1876913)
date added to LUP
2016-04-01 13:18:42
date last changed
2022-01-27 18:29:52
@article{e76afd05-361d-41a5-9346-815a14e2dde0,
  abstract     = {{Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99&lt;SUth&lt;/SU percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels &gt; three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was &gt; 3x99%URL in 58/486 patients (12%) and cTnI &gt; 3x99%URL in 292/487 patients (60%). cTnI was &gt; 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range from 1x to 10x99%URL and those with CK-MB 1x to 10x99%URL. Conclusions. With the present quantification scales, infarction rate after PCI is &gt; five-fold higher with cTnI than with CK-MB.}},
  author       = {{Gustavsson, Carl Gunnar and Nilson, Margareta}},
  issn         = {{1651-2006}},
  keywords     = {{Angioplasty; CK-MB; creatine kinase; infarction; PCI troponin}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{21--26}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Cardiovascular Journal}},
  title        = {{Troponin I and Creatine Kinase MB do not provide comparable information after PCI}},
  url          = {{http://dx.doi.org/10.3109/14017431.2010.536989}},
  doi          = {{10.3109/14017431.2010.536989}},
  volume       = {{45}},
  year         = {{2011}},
}