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Phase separation and dynamical arrest for particles interacting with mixed potentials-the case of globular proteins revisited

Gibaud, Thomas; Cardinaux, Frederic; Bergenholtz, Johan; Stradner, Anna and Schurtenberger, Peter LU (2011) In Soft Matter 7(3). p.857-860
Abstract
We examine the applicability of the extended law of corresponding states (ELCS) to equilibrium and non equilibrium features of the state diagram of the globular protein lysozyme. We provide compelling evidence that the ELCS correctly reproduces the location of the binodal for different ionic strengths, but fails in describing the location of the arrest line. We subsequently use Mode Coupling Theory (MCT) to gain additional insight into the origin of these observations. We demonstrate that while the critical point and the connected binodal and spinodal are governed by the integral features of the interaction potential described by the normalized second virial coefficient, the arrest line is mainly determined by the attractive well depth or... (More)
We examine the applicability of the extended law of corresponding states (ELCS) to equilibrium and non equilibrium features of the state diagram of the globular protein lysozyme. We provide compelling evidence that the ELCS correctly reproduces the location of the binodal for different ionic strengths, but fails in describing the location of the arrest line. We subsequently use Mode Coupling Theory (MCT) to gain additional insight into the origin of these observations. We demonstrate that while the critical point and the connected binodal and spinodal are governed by the integral features of the interaction potential described by the normalized second virial coefficient, the arrest line is mainly determined by the attractive well depth or bond strength. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
7
issue
3
pages
857 - 860
publisher
Royal Society of Chemistry
external identifiers
  • wos:000286615500005
  • scopus:79251491332
ISSN
1744-6848
DOI
10.1039/c0sm01175d
language
English
LU publication?
yes
id
949bf0e3-4818-463f-80b5-ec79f249b29b (old id 1878231)
date added to LUP
2011-04-14 09:11:24
date last changed
2017-09-24 04:00:15
@article{949bf0e3-4818-463f-80b5-ec79f249b29b,
  abstract     = {We examine the applicability of the extended law of corresponding states (ELCS) to equilibrium and non equilibrium features of the state diagram of the globular protein lysozyme. We provide compelling evidence that the ELCS correctly reproduces the location of the binodal for different ionic strengths, but fails in describing the location of the arrest line. We subsequently use Mode Coupling Theory (MCT) to gain additional insight into the origin of these observations. We demonstrate that while the critical point and the connected binodal and spinodal are governed by the integral features of the interaction potential described by the normalized second virial coefficient, the arrest line is mainly determined by the attractive well depth or bond strength.},
  author       = {Gibaud, Thomas and Cardinaux, Frederic and Bergenholtz, Johan and Stradner, Anna and Schurtenberger, Peter},
  issn         = {1744-6848},
  language     = {eng},
  number       = {3},
  pages        = {857--860},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Phase separation and dynamical arrest for particles interacting with mixed potentials-the case of globular proteins revisited},
  url          = {http://dx.doi.org/10.1039/c0sm01175d},
  volume       = {7},
  year         = {2011},
}