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The use of a proposed updated EARL harmonization of 18F-FDG PET-CT in patients with lymphoma yields significant differences in Deauville score compared with current EARL recommendations

Ly, John LU ; Minarik, David LU ; Edenbrandt, Lars LU ; Wollmer, Per LU and Trägårdh, Elin LU (2019) In EJNMMI Research 9(1).
Abstract

Background: The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting their disease status. With a plethora of positron emission tomography with computed tomography (PET-CT) hard- and software algorithms, standard uptake value (SUV) in lesions and reference organs may differ which affects DS classification and therefore medical treatment. The EANM Research Ltd. (EARL) harmonization program from the European Association of Nuclear Medicine (EANM) partly mitigates this issue, but local preferences are common in clinical practice. We have investigated the discordance in DS... (More)

Background: The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting their disease status. With a plethora of positron emission tomography with computed tomography (PET-CT) hard- and software algorithms, standard uptake value (SUV) in lesions and reference organs may differ which affects DS classification and therefore medical treatment. The EANM Research Ltd. (EARL) harmonization program from the European Association of Nuclear Medicine (EANM) partly mitigates this issue, but local preferences are common in clinical practice. We have investigated the discordance in DS calculated from patients with lymphoma referred for 18F-FDG PET-CT reconstructed with three different algorithms: the newly introduced block-sequential regularization expectation-maximization algorithm commercially sold as Q. Clear (QC, GE Healthcare, Milwaukee, WI, USA), compliant with the newly proposed updated EARL recommendations, and two settings compliant with the current EARL recommendations (EARLlower and EARLupper, representing the lower and upper limit of the EARL recommendations). Methods: Fifty-two patients with non-Hodgkin and Hodgkin lymphoma were included (18 females and 34 males). Segmentation of mediastinal blood pool and liver were semi-automatically performed, whereas segmentation of lesions was done manually. From these segmentations, SUVmax and SUVpeak were obtained and DS calculated. Results: There was a significant difference in DS between the QC algorithm and EARLlower/EARLupper (p < 0.0001 for both) but not between EARLlower and EARLupper (p = 0.102) when SUVmax was used. For SUVpeak, there was a significant difference between QC and EARLlower (p = 0.001), but not for QC vs EARLupper (p = 0.071) or EARLlower vs EARLupper (p = 0.102). Five non-responders (DS 4–5) for QC were classified as responders (DS 1–3) when EARLlower/EARLupper was used, both when SUVmax and SUVpeak were investigated. Conclusion: Using the proposed updated EARL recommendations compared with the current recommendations will significantly change DS classification. In select cases, the discordance would affect the choice of medical treatment. Specifically, the current EARL recommendations were more often prone to classify patients as responders.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Deauville score, EARL, Lymphoma, PET, Reconstruction algorithm
in
EJNMMI Research
volume
9
issue
1
article number
65
publisher
BioMed Central
external identifiers
  • scopus:85069697306
ISSN
2191-219X
DOI
10.1186/s13550-019-0536-3
language
English
LU publication?
yes
id
187e9d22-6301-4c25-997f-e18a996dec5b
date added to LUP
2019-08-02 08:52:25
date last changed
2019-12-03 02:17:19
@article{187e9d22-6301-4c25-997f-e18a996dec5b,
  abstract     = {<p>Background: The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of <sup>18</sup>F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting their disease status. With a plethora of positron emission tomography with computed tomography (PET-CT) hard- and software algorithms, standard uptake value (SUV) in lesions and reference organs may differ which affects DS classification and therefore medical treatment. The EANM Research Ltd. (EARL) harmonization program from the European Association of Nuclear Medicine (EANM) partly mitigates this issue, but local preferences are common in clinical practice. We have investigated the discordance in DS calculated from patients with lymphoma referred for <sup>18</sup>F-FDG PET-CT reconstructed with three different algorithms: the newly introduced block-sequential regularization expectation-maximization algorithm commercially sold as Q. Clear (QC, GE Healthcare, Milwaukee, WI, USA), compliant with the newly proposed updated EARL recommendations, and two settings compliant with the current EARL recommendations (EARL<sub>lower</sub> and EARL<sub>upper</sub>, representing the lower and upper limit of the EARL recommendations). Methods: Fifty-two patients with non-Hodgkin and Hodgkin lymphoma were included (18 females and 34 males). Segmentation of mediastinal blood pool and liver were semi-automatically performed, whereas segmentation of lesions was done manually. From these segmentations, SUV<sub>max</sub> and SUV<sub>peak</sub> were obtained and DS calculated. Results: There was a significant difference in DS between the QC algorithm and EARL<sub>lower</sub>/EARL<sub>upper</sub> (p &lt; 0.0001 for both) but not between EARL<sub>lower</sub> and EARL<sub>upper</sub> (p = 0.102) when SUV<sub>max</sub> was used. For SUV<sub>peak</sub>, there was a significant difference between QC and EARL<sub>lower</sub> (p = 0.001), but not for QC vs EARL<sub>upper</sub> (p = 0.071) or EARL<sub>lower</sub> vs EARL<sub>upper</sub> (p = 0.102). Five non-responders (DS 4–5) for QC were classified as responders (DS 1–3) when EARL<sub>lower</sub>/EARL<sub>upper</sub> was used, both when SUV<sub>max</sub> and SUV<sub>peak</sub> were investigated. Conclusion: Using the proposed updated EARL recommendations compared with the current recommendations will significantly change DS classification. In select cases, the discordance would affect the choice of medical treatment. Specifically, the current EARL recommendations were more often prone to classify patients as responders.</p>},
  author       = {Ly, John and Minarik, David and Edenbrandt, Lars and Wollmer, Per and Trägårdh, Elin},
  issn         = {2191-219X},
  language     = {eng},
  month        = {07},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {EJNMMI Research},
  title        = {The use of a proposed updated EARL harmonization of <sup>18</sup>F-FDG PET-CT in patients with lymphoma yields significant differences in Deauville score compared with current EARL recommendations},
  url          = {http://dx.doi.org/10.1186/s13550-019-0536-3},
  doi          = {10.1186/s13550-019-0536-3},
  volume       = {9},
  year         = {2019},
}