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LUCAS - Lund University Cardiopulmonary Assist System

Liao, Qiuming LU (2011) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2011:34.
Abstract
Lund University Cardiopulmonary Assist System (LUCAS) is a mechanical device providing automatic 5 cm deep chest compressions and active decompressions back to normal anatomical position with a frequency of 100 per minute, and a duty cycle of 50%, i.e., LUCAS is constructed to give chest compressions according to the latest international guidelines in cardiopulmonary resuscitation (CPR).



The aim of the thesis was to study cardiac arrest using different porcine models of ventricular fibrillation. Four hypotheses were formulated:

1. LUCAS-CPR is superior to manual CPR regarding coronary perfusion pressure (CPP) and return of spontaneous circulation (ROSC).

2. Hypothermic LUCAS-CPR is superior to... (More)
Lund University Cardiopulmonary Assist System (LUCAS) is a mechanical device providing automatic 5 cm deep chest compressions and active decompressions back to normal anatomical position with a frequency of 100 per minute, and a duty cycle of 50%, i.e., LUCAS is constructed to give chest compressions according to the latest international guidelines in cardiopulmonary resuscitation (CPR).



The aim of the thesis was to study cardiac arrest using different porcine models of ventricular fibrillation. Four hypotheses were formulated:

1. LUCAS-CPR is superior to manual CPR regarding coronary perfusion pressure (CPP) and return of spontaneous circulation (ROSC).

2. Hypothermic LUCAS-CPR is superior to normothermic LUCAS-CPR in treating prolonged ventricular fibrillation.

3. The rate of ROSC after prolonged ventricular fibrillation will increase if LUCAS-CPR is given before defibrillation, and if defibrillation is given during on-going chest compressions.

4. LUCAS-CPR will cause fewer rib fractures than manual CPR.



LUCAS-CPR gave significantly higher rates of ROSC and significantly higher CPP than manual CPR. LUCAS-CPR combined with surface cooling to 34°C was superior to normothermic LUCAS-CPR during 1 hour of CPR for ventricular fibrillation. Defibrillation was more effective to obtain ROSC after prolonged ventricular fibrillation if chest compressions were done before the shock, and if the shock was given during on-going LUCAS-CPR. LUCAS-CPR caused significantly fewer rib fractures during 20 minutes of CPR compared to manual CPR. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Herlitz, Johan, Department of Cardiology, Sahlgrenska University Hospital, Gothenburg
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Cardiopulmonary resuscitation, Chest compression, Active chest decompression, Mechanical CPR, Defibrillation, Hypothermia
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2011:34
pages
94 pages
publisher
Department of Cardiothoracic Surgery, Clinical Sciences, Lund University
defense location
Föreläsningssal 3, Skånes universitetssjukhus, Lund
defense date
2011-04-27 09:15
external identifiers
  • scopus:79955695223
ISSN
1652-8220
ISBN
978-91-86671-82-2
language
English
LU publication?
yes
id
35caba0c-6629-4dce-a66a-ce47fd4e4166 (old id 1883004)
date added to LUP
2011-04-07 10:05:39
date last changed
2017-01-01 06:12:27
@phdthesis{35caba0c-6629-4dce-a66a-ce47fd4e4166,
  abstract     = {Lund University Cardiopulmonary Assist System (LUCAS) is a mechanical device providing automatic 5 cm deep chest compressions and active decompressions back to normal anatomical position with a frequency of 100 per minute, and a duty cycle of 50%, i.e., LUCAS is constructed to give chest compressions according to the latest international guidelines in cardiopulmonary resuscitation (CPR). <br/><br>
<br/><br>
The aim of the thesis was to study cardiac arrest using different porcine models of ventricular fibrillation. Four hypotheses were formulated:<br/><br>
1.	LUCAS-CPR is superior to manual CPR regarding coronary perfusion pressure (CPP) and return of spontaneous circulation (ROSC).<br/><br>
2.	Hypothermic LUCAS-CPR is superior to normothermic LUCAS-CPR in treating prolonged ventricular fibrillation.<br/><br>
3.	The rate of ROSC after prolonged ventricular fibrillation will increase if LUCAS-CPR is given before defibrillation, and if defibrillation is given during on-going chest compressions.<br/><br>
4.	LUCAS-CPR will cause fewer rib fractures than manual CPR.<br/><br>
<br/><br>
LUCAS-CPR gave significantly higher rates of ROSC and significantly higher CPP than manual CPR. LUCAS-CPR combined with surface cooling to 34°C was superior to normothermic LUCAS-CPR during 1 hour of CPR for ventricular fibrillation. Defibrillation was more effective to obtain ROSC after prolonged ventricular fibrillation if chest compressions were done before the shock, and if the shock was given during on-going LUCAS-CPR. LUCAS-CPR caused significantly fewer rib fractures during 20 minutes of CPR compared to manual CPR.},
  author       = {Liao, Qiuming},
  isbn         = {978-91-86671-82-2},
  issn         = {1652-8220},
  keyword      = {Cardiopulmonary resuscitation,Chest compression,Active chest decompression,Mechanical CPR,Defibrillation,Hypothermia},
  language     = {eng},
  pages        = {94},
  publisher    = {Department of Cardiothoracic Surgery, Clinical Sciences, Lund University},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {LUCAS - Lund University Cardiopulmonary Assist System},
  volume       = {2011:34},
  year         = {2011},
}