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Early Cellular Pathways of Mouse Natural Killer Cell Development.

Sitnicka Quinn, Ewa LU (2011) In Journal of Innate Immunity 3(4). p.329-336
Abstract
Natural killer (NK) cells are large granular lymphocytes that are components of the innate immune system. These cells are key players in the defense against viral and other microbial infections and cancer and have an important function during pregnancy, autoimmunity and allergy. Furthermore, NK cells play important roles in hematopoietic stem cell (HSC) transplantation by providing the graft versus leukemia effect and preventing the development of graft versus host disease. Thus, understanding the developmental pathway(s) from multipotent HSCs to the NK cell lineage-restricted progenitors is of significant clinical value. However, despite extensive progress in the delineation of mature blood cell development, including the B- and T-cell... (More)
Natural killer (NK) cells are large granular lymphocytes that are components of the innate immune system. These cells are key players in the defense against viral and other microbial infections and cancer and have an important function during pregnancy, autoimmunity and allergy. Furthermore, NK cells play important roles in hematopoietic stem cell (HSC) transplantation by providing the graft versus leukemia effect and preventing the development of graft versus host disease. Thus, understanding the developmental pathway(s) from multipotent HSCs to the NK cell lineage-restricted progenitors is of significant clinical value. However, despite extensive progress in the delineation of mature blood cell development, including the B- and T-cell lineages, the early stages of NK cell lineage commitment and development have been less well established and characterized. Here, I review the progress made thus far in dissecting the developmental stages, from HSCs in the bone marrow to the lineage-committed NK cells in mouse. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Innate Immunity
volume
3
issue
4
pages
329 - 336
publisher
Karger
external identifiers
  • wos:000292065600002
  • pmid:21447931
  • scopus:79959645128
ISSN
1662-811X
DOI
10.1159/000323925
language
English
LU publication?
yes
id
20871f5f-251c-4847-af8a-a45659187f00 (old id 1883302)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21447931?dopt=Abstract
date added to LUP
2011-04-01 22:36:44
date last changed
2017-01-12 08:48:08
@article{20871f5f-251c-4847-af8a-a45659187f00,
  abstract     = {Natural killer (NK) cells are large granular lymphocytes that are components of the innate immune system. These cells are key players in the defense against viral and other microbial infections and cancer and have an important function during pregnancy, autoimmunity and allergy. Furthermore, NK cells play important roles in hematopoietic stem cell (HSC) transplantation by providing the graft versus leukemia effect and preventing the development of graft versus host disease. Thus, understanding the developmental pathway(s) from multipotent HSCs to the NK cell lineage-restricted progenitors is of significant clinical value. However, despite extensive progress in the delineation of mature blood cell development, including the B- and T-cell lineages, the early stages of NK cell lineage commitment and development have been less well established and characterized. Here, I review the progress made thus far in dissecting the developmental stages, from HSCs in the bone marrow to the lineage-committed NK cells in mouse.},
  author       = {Sitnicka Quinn, Ewa},
  issn         = {1662-811X},
  language     = {eng},
  number       = {4},
  pages        = {329--336},
  publisher    = {Karger},
  series       = {Journal of Innate Immunity},
  title        = {Early Cellular Pathways of Mouse Natural Killer Cell Development.},
  url          = {http://dx.doi.org/10.1159/000323925},
  volume       = {3},
  year         = {2011},
}