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Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density.

Belfrage, Ola LU ; Flivik, Gunnar LU ; Sundberg, Martin LU ; Kesteris, Uldis LU and Tägil, Magnus LU (2011) In Acta Orthopaedica 82(2). p.228-233
Abstract
Background and purpose The remodeling of morselized bone grafts in revision surgery can be enhanced by an anabolic substance such as a bone morphogenetic protein (BMP). On the other hand, BMPs boost catabolism and might cause a premature resorption, both of the graft and of the new-formed bone. Bisphosphonates inactivate osteoclasts and can be used to control the resorption. We studied a combination of both drugs as a local admix to a cancellous allograft. Methods Cancellous bone allografts were harvested and freeze-dried. Either saline, BMP-7, the bisphosphonate zoledronate, or a combination of BMP-7 and zoledronate were added in solution. The grafts were placed in bone conduction chambers and implanted in the proximal tibia of 34 rats.... (More)
Background and purpose The remodeling of morselized bone grafts in revision surgery can be enhanced by an anabolic substance such as a bone morphogenetic protein (BMP). On the other hand, BMPs boost catabolism and might cause a premature resorption, both of the graft and of the new-formed bone. Bisphosphonates inactivate osteoclasts and can be used to control the resorption. We studied a combination of both drugs as a local admix to a cancellous allograft. Methods Cancellous bone allografts were harvested and freeze-dried. Either saline, BMP-7, the bisphosphonate zoledronate, or a combination of BMP-7 and zoledronate were added in solution. The grafts were placed in bone conduction chambers and implanted in the proximal tibia of 34 rats. The grafts were harvested after 6 weeks and evaluated by histomorphometry. Results Bone volume/total volume (BV/TV) was 50% in the grafts treated with the combination of BMP-7 and zoledronate and 16% in the saline controls (p < 0.001). In the zoledronate group BV/TV was 56%, and in the BMP group it was 14%. The ingrowth distance of new bone into the graft was 3.5 mm for the combination of BMP-7 and zoledronate and 2.6 mm in the saline control (p = 0.002). The net amount of retained remodeled bone was more than 4 times higher when BMP-7 and zoledronate were combined than in the controls. Interpretation An anabolic drug like BMP-7 can be combined with an anti-catabolic bisphosphonate as local bone graft adjunct, and the combination increases the amount of remaining bone after remodeling is complete. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Orthopaedica
volume
82
issue
2
pages
228 - 233
publisher
Taylor & Francis
external identifiers
  • wos:000289170900018
  • pmid:21434769
  • scopus:79953814937
ISSN
1745-3682
DOI
10.3109/17453674.2011.566138
language
English
LU publication?
yes
id
947bfd90-2a14-41cd-911c-e4c0cea29a59 (old id 1883498)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21434769?dopt=Abstract
date added to LUP
2011-04-01 21:13:48
date last changed
2017-03-26 03:46:39
@article{947bfd90-2a14-41cd-911c-e4c0cea29a59,
  abstract     = {Background and purpose The remodeling of morselized bone grafts in revision surgery can be enhanced by an anabolic substance such as a bone morphogenetic protein (BMP). On the other hand, BMPs boost catabolism and might cause a premature resorption, both of the graft and of the new-formed bone. Bisphosphonates inactivate osteoclasts and can be used to control the resorption. We studied a combination of both drugs as a local admix to a cancellous allograft. Methods Cancellous bone allografts were harvested and freeze-dried. Either saline, BMP-7, the bisphosphonate zoledronate, or a combination of BMP-7 and zoledronate were added in solution. The grafts were placed in bone conduction chambers and implanted in the proximal tibia of 34 rats. The grafts were harvested after 6 weeks and evaluated by histomorphometry. Results Bone volume/total volume (BV/TV) was 50% in the grafts treated with the combination of BMP-7 and zoledronate and 16% in the saline controls (p &lt; 0.001). In the zoledronate group BV/TV was 56%, and in the BMP group it was 14%. The ingrowth distance of new bone into the graft was 3.5 mm for the combination of BMP-7 and zoledronate and 2.6 mm in the saline control (p = 0.002). The net amount of retained remodeled bone was more than 4 times higher when BMP-7 and zoledronate were combined than in the controls. Interpretation An anabolic drug like BMP-7 can be combined with an anti-catabolic bisphosphonate as local bone graft adjunct, and the combination increases the amount of remaining bone after remodeling is complete.},
  author       = {Belfrage, Ola and Flivik, Gunnar and Sundberg, Martin and Kesteris, Uldis and Tägil, Magnus},
  issn         = {1745-3682},
  language     = {eng},
  number       = {2},
  pages        = {228--233},
  publisher    = {Taylor & Francis},
  series       = {Acta Orthopaedica},
  title        = {Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density.},
  url          = {http://dx.doi.org/10.3109/17453674.2011.566138},
  volume       = {82},
  year         = {2011},
}