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Receptive Field Remodeling Induced by Skin Stimulation in Cerebellar Neurons in vivo.

Jörntell, Henrik LU and Ekerot, Carl-Fredrik LU (2011) In Frontiers in Neural Circuits 5.
Abstract
The receptive field of a neuron reflects its function. For example, for parallel fiber (PF) inputs in C3 zone the cerebellar cortex, the excitatory and inhibitory receptive fields of a Purkinje cell (PC) have different locations, and each location has a specific relationship to the location of the climbing fiber (CF) receptive field of the PC. Previous studies have shown that this pattern of input connectivity to the PC and its afferent inhibitory interneurons can be fundamentally disrupted by applying direct electrical stimulation to the PFs, paired or unpaired with CF activation, with protocols that induce plasticity in these synapses. However, afferent fiber stimulation, which is typically used in experimental studies of plasticity, set... (More)
The receptive field of a neuron reflects its function. For example, for parallel fiber (PF) inputs in C3 zone the cerebellar cortex, the excitatory and inhibitory receptive fields of a Purkinje cell (PC) have different locations, and each location has a specific relationship to the location of the climbing fiber (CF) receptive field of the PC. Previous studies have shown that this pattern of input connectivity to the PC and its afferent inhibitory interneurons can be fundamentally disrupted by applying direct electrical stimulation to the PFs, paired or unpaired with CF activation, with protocols that induce plasticity in these synapses. However, afferent fiber stimulation, which is typically used in experimental studies of plasticity, set up highly artificial input patterns at the level of the recipient cells, raising the issue that these forms of plasticity potentially may not occur under more natural input patterns. Here we used skin stimulation to set up spatiotemporally more realistic afferent input patterns in the PFs to investigate whether these input patterns are also capable of inducing synaptic plasticity using similar protocols that have previously been described for direct PF stimulation. We find that receptive field components can be added to and removed from PCs and interneurons following brief periods of skin stimulation. Following these protocols, the receptive fields of mossy fibers were unchanged. These findings confirm that previously described plasticity protocols may have a functional role also for more normal patterns of afferent input. (Less)
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organization
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Contribution to journal
publication status
published
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in
Frontiers in Neural Circuits
volume
5
publisher
Frontiers
external identifiers
  • WOS:000289574500001
  • PMID:21427779
  • Scopus:84860216094
ISSN
1662-5110
DOI
10.3389/fncir.2011.00003
language
English
LU publication?
yes
id
309eb46a-5e5d-40f1-a357-360d2429857d (old id 1883596)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21427779?dopt=Abstract
date added to LUP
2011-04-01 20:30:15
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2017-01-15 04:27:39
@article{309eb46a-5e5d-40f1-a357-360d2429857d,
  abstract     = {The receptive field of a neuron reflects its function. For example, for parallel fiber (PF) inputs in C3 zone the cerebellar cortex, the excitatory and inhibitory receptive fields of a Purkinje cell (PC) have different locations, and each location has a specific relationship to the location of the climbing fiber (CF) receptive field of the PC. Previous studies have shown that this pattern of input connectivity to the PC and its afferent inhibitory interneurons can be fundamentally disrupted by applying direct electrical stimulation to the PFs, paired or unpaired with CF activation, with protocols that induce plasticity in these synapses. However, afferent fiber stimulation, which is typically used in experimental studies of plasticity, set up highly artificial input patterns at the level of the recipient cells, raising the issue that these forms of plasticity potentially may not occur under more natural input patterns. Here we used skin stimulation to set up spatiotemporally more realistic afferent input patterns in the PFs to investigate whether these input patterns are also capable of inducing synaptic plasticity using similar protocols that have previously been described for direct PF stimulation. We find that receptive field components can be added to and removed from PCs and interneurons following brief periods of skin stimulation. Following these protocols, the receptive fields of mossy fibers were unchanged. These findings confirm that previously described plasticity protocols may have a functional role also for more normal patterns of afferent input.},
  articleno    = {3},
  author       = {Jörntell, Henrik and Ekerot, Carl-Fredrik},
  issn         = {1662-5110},
  language     = {eng},
  publisher    = {Frontiers},
  series       = {Frontiers in Neural Circuits},
  title        = {Receptive Field Remodeling Induced by Skin Stimulation in Cerebellar Neurons in vivo.},
  url          = {http://dx.doi.org/10.3389/fncir.2011.00003},
  volume       = {5},
  year         = {2011},
}