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Changes in immunocompetent cells after interstitial laser thermotherapy of breast cancer.

Huld-Haraldsdottir, Kristin LU ; Ivarsson, Kjell LU ; Jansner, Karin LU ; Stenram, Unne LU and Tranberg, Karl-Göran LU (2011) In Cancer immunology, immunotherapy : CII 60. p.847-856
Abstract
BACKGROUND: Local tumour destruction has been shown to give rise to changes in immunocompetent cells. The aim of this study was to describe the effect of interstitial laser thermotherapy (ILT) of breast carcinoma in the tumour and in regional lymph nodes. METHODS: Seventeen women that underwent radical surgical excision after non-radical ILT were studied. ILT was performed at a steady-state temperature of 48°C for 30 min. Surgical excision was performed 12 (6-23) days after ILT. Six patients with breast cancer not treated with ILT before surgery served as controls. Immunohistological reactions were performed on core needle biopsies prior to treatment and on the excised specimens. RESULTS: ILT resulted in more CD8 lymphocytes and CD68... (More)
BACKGROUND: Local tumour destruction has been shown to give rise to changes in immunocompetent cells. The aim of this study was to describe the effect of interstitial laser thermotherapy (ILT) of breast carcinoma in the tumour and in regional lymph nodes. METHODS: Seventeen women that underwent radical surgical excision after non-radical ILT were studied. ILT was performed at a steady-state temperature of 48°C for 30 min. Surgical excision was performed 12 (6-23) days after ILT. Six patients with breast cancer not treated with ILT before surgery served as controls. Immunohistological reactions were performed on core needle biopsies prior to treatment and on the excised specimens. RESULTS: ILT resulted in more CD8 lymphocytes and CD68 macrophages within the tumour (P < 0.05 and P < 0.01, respectively) and higher counts of CD20 (P < 0.05), CD68 (P < 0.001) and CD83 (P < 0.01) at the tumour border, when compared to pre-treatment values. In the control patients not receiving ILT, CD8 cells increased within the tumour after resection (P < 0.05). With the probable exception of CD25 Foxp3 cells, the presence of cancer in a lymph node influenced the findings in lymph nodes (examined for CD1a, CD25, Foxp3 CD25, CD83 cells). Thus, comparisons between ILT and control patients were restricted to patients without lymph node metastases. In these patients, ILT and resection were followed by a decrease in CD25 Foxp3 lymphocytes (P < 0.05), when compared to surgical resection alone. CONCLUSIONS: ILT induced changes in immunocompetent cells in patients with breast cancer. The stimulation of the immune system is an added feature of ILT in treatment of patients with breast cancer. (Less)
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; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer immunology, immunotherapy : CII
volume
60
pages
847 - 856
publisher
Springer
external identifiers
  • wos:000290802200009
  • pmid:21400025
  • scopus:79959748880
  • pmid:21400025
ISSN
1432-0851
DOI
10.1007/s00262-011-0992-8
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Airway Inflammation and Immunology (013212038), Surgery (Lund) (013009000), Medicine (Lund) (013230025)
id
952d4299-53cf-4b15-86f5-b5fbbb2a9776 (old id 1884036)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21400025?dopt=Abstract
date added to LUP
2016-04-04 09:17:56
date last changed
2021-08-11 03:43:11
@article{952d4299-53cf-4b15-86f5-b5fbbb2a9776,
  abstract     = {BACKGROUND: Local tumour destruction has been shown to give rise to changes in immunocompetent cells. The aim of this study was to describe the effect of interstitial laser thermotherapy (ILT) of breast carcinoma in the tumour and in regional lymph nodes. METHODS: Seventeen women that underwent radical surgical excision after non-radical ILT were studied. ILT was performed at a steady-state temperature of 48°C for 30 min. Surgical excision was performed 12 (6-23) days after ILT. Six patients with breast cancer not treated with ILT before surgery served as controls. Immunohistological reactions were performed on core needle biopsies prior to treatment and on the excised specimens. RESULTS: ILT resulted in more CD8 lymphocytes and CD68 macrophages within the tumour (P &lt; 0.05 and P &lt; 0.01, respectively) and higher counts of CD20 (P &lt; 0.05), CD68 (P &lt; 0.001) and CD83 (P &lt; 0.01) at the tumour border, when compared to pre-treatment values. In the control patients not receiving ILT, CD8 cells increased within the tumour after resection (P &lt; 0.05). With the probable exception of CD25 Foxp3 cells, the presence of cancer in a lymph node influenced the findings in lymph nodes (examined for CD1a, CD25, Foxp3 CD25, CD83 cells). Thus, comparisons between ILT and control patients were restricted to patients without lymph node metastases. In these patients, ILT and resection were followed by a decrease in CD25 Foxp3 lymphocytes (P &lt; 0.05), when compared to surgical resection alone. CONCLUSIONS: ILT induced changes in immunocompetent cells in patients with breast cancer. The stimulation of the immune system is an added feature of ILT in treatment of patients with breast cancer.},
  author       = {Huld-Haraldsdottir, Kristin and Ivarsson, Kjell and Jansner, Karin and Stenram, Unne and Tranberg, Karl-Göran},
  issn         = {1432-0851},
  language     = {eng},
  pages        = {847--856},
  publisher    = {Springer},
  series       = {Cancer immunology, immunotherapy : CII},
  title        = {Changes in immunocompetent cells after interstitial laser thermotherapy of breast cancer.},
  url          = {https://lup.lub.lu.se/search/files/5286190/1890629.pdf},
  doi          = {10.1007/s00262-011-0992-8},
  volume       = {60},
  year         = {2011},
}