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Expression of FK506 binding protein 65 (FKBP65) is decreased in epithelial ovarian cancer cells compared to benign tumor cells and to ovarian epithelium.

Henriksen, Rudi LU ; Sørensen, Flemming Brandt; Orntoft, Torben Falck and Birkenkamp-Demtroder, Karin (2011) In Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 32. p.671-676
Abstract
FK506 binding protein 65 (FKBP65) belongs to a group of proteins termed immunophilins that have a high binding affinity to immunosuppressant drugs as FK506 (tacrolimus) and rapamycin (sirolimus). Treatment of female premenopausal women with tacrolimus, which binds to FKBP65, has been reported to be followed by a strongly increased risk of ovarian cysts. We performed the present study to reveal how FKBP65 is expressed in the ovary and in ovarian tumors and to see if this expression might be related to ovarian tumor development, a relationship we have found in colorectal cancer. Biopsies from prospectively collected samples from ovaries and benign, borderline, and invasive ovarian tumors were analyzed for expression of FKBP65 by... (More)
FK506 binding protein 65 (FKBP65) belongs to a group of proteins termed immunophilins that have a high binding affinity to immunosuppressant drugs as FK506 (tacrolimus) and rapamycin (sirolimus). Treatment of female premenopausal women with tacrolimus, which binds to FKBP65, has been reported to be followed by a strongly increased risk of ovarian cysts. We performed the present study to reveal how FKBP65 is expressed in the ovary and in ovarian tumors and to see if this expression might be related to ovarian tumor development, a relationship we have found in colorectal cancer. Biopsies from prospectively collected samples from ovaries and benign, borderline, and invasive ovarian tumors were analyzed for expression of FKBP65 by immunohistochemistry. The expression was compared to survival and several clinicopathological parameters. FKBP65 is strongly expressed in ovarian epithelium and in benign ovarian tumor cells. In the ovary, a positive staining was also found in endothelial cells of blood vessels. In non-invasive and in invasive malignant tumor cells, a decreased staining was observed, which was not correlated to stage, histology, or survival. A significant inversed correlation to expression of p53 was found. The differential expression of FKBP65 indicates a role in ovarian physiology as well as in ovarian tumor development. Our observations and the chromosomal localization of the FKBP65 gene indicate a tumor suppressor function of the FKBP65 protein in ovarian carcinogenesis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
volume
32
pages
671 - 676
publisher
Springer
external identifiers
  • WOS:000292558600007
  • PMID:21399973
  • Scopus:80052333239
ISSN
1423-0380
DOI
10.1007/s13277-011-0167-4
language
English
LU publication?
yes
id
cd632d98-83b4-4c56-8e08-06ec6da6ed96 (old id 1884044)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21399973?dopt=Abstract
date added to LUP
2011-04-01 15:35:09
date last changed
2017-01-01 07:50:52
@article{cd632d98-83b4-4c56-8e08-06ec6da6ed96,
  abstract     = {FK506 binding protein 65 (FKBP65) belongs to a group of proteins termed immunophilins that have a high binding affinity to immunosuppressant drugs as FK506 (tacrolimus) and rapamycin (sirolimus). Treatment of female premenopausal women with tacrolimus, which binds to FKBP65, has been reported to be followed by a strongly increased risk of ovarian cysts. We performed the present study to reveal how FKBP65 is expressed in the ovary and in ovarian tumors and to see if this expression might be related to ovarian tumor development, a relationship we have found in colorectal cancer. Biopsies from prospectively collected samples from ovaries and benign, borderline, and invasive ovarian tumors were analyzed for expression of FKBP65 by immunohistochemistry. The expression was compared to survival and several clinicopathological parameters. FKBP65 is strongly expressed in ovarian epithelium and in benign ovarian tumor cells. In the ovary, a positive staining was also found in endothelial cells of blood vessels. In non-invasive and in invasive malignant tumor cells, a decreased staining was observed, which was not correlated to stage, histology, or survival. A significant inversed correlation to expression of p53 was found. The differential expression of FKBP65 indicates a role in ovarian physiology as well as in ovarian tumor development. Our observations and the chromosomal localization of the FKBP65 gene indicate a tumor suppressor function of the FKBP65 protein in ovarian carcinogenesis.},
  author       = {Henriksen, Rudi and Sørensen, Flemming Brandt and Orntoft, Torben Falck and Birkenkamp-Demtroder, Karin},
  issn         = {1423-0380},
  language     = {eng},
  pages        = {671--676},
  publisher    = {Springer},
  series       = {Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  title        = {Expression of FK506 binding protein 65 (FKBP65) is decreased in epithelial ovarian cancer cells compared to benign tumor cells and to ovarian epithelium.},
  url          = {http://dx.doi.org/10.1007/s13277-011-0167-4},
  volume       = {32},
  year         = {2011},
}