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Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer

Broberg, Olof LU ; Feldreich, Tobias ; Weismann, Constance G. LU orcid ; Øra, Ingrid LU ; Wiebe, Thomas LU ; Ärnlöv, Johan and Liuba, Petru LU (2024) In Cardiology in the Young
Abstract

Introduction: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclinical cardiovascular disease. Methods: Ninety-two cardiovascular proteins were measured in 57 childhood cancer survivors and in 52 controls. For proteins that were significantly different between childhood cancer survivors and controls, we performed correlations between protein levels and measures of peripheral arterial stiffness (carotid... (More)

Introduction: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclinical cardiovascular disease. Methods: Ninety-two cardiovascular proteins were measured in 57 childhood cancer survivors and in 52 controls. For proteins that were significantly different between childhood cancer survivors and controls, we performed correlations between protein levels and measures of peripheral arterial stiffness (carotid distensibility and stiffness index, and augmentation index) and endothelial dysfunction (reactive hyperemia index). Results: Leptin was significantly higher in childhood cancer survivors compared to controls (normalized protein expression units: childhood cancer survivors 6.4 (1.5) versus 5.1 (1.7), p < 0.0000001) after taking multiple tests into account. Kidney injury molecule-1, MER proto-oncogene tyrosine kinase, selectin P ligand, decorin, alpha-1-microglobulin/bikunin precursor protein, and pentraxin 3 showed a trend towards group differences (p < 0.05). Among childhood cancer survivors, leptin was associated with anthracycline treatment after adjustment for age, sex, and body mass index (p < 0.0001). Higher leptin correlated with lower carotid distensibility after adjustment for age, sex, body mass index, and treatments with radiotherapy and anthracyclines (p = 0.005). Conclusion: This proteomics approach identified that leptin is higher in young asymptomatic adult survivors of childhood cancer than in healthy controls and is associated with adverse vascular changes. This could indicate a role for leptin in driving the cardiovascular disease burden in this population.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
biomarker, cardiotoxicity, childhood cancer survivors, leptin, vasculotoxicity
in
Cardiology in the Young
publisher
Cambridge University Press
external identifiers
  • scopus:85184473394
  • pmid:38305049
ISSN
1047-9511
DOI
10.1017/S1047951124000076
language
English
LU publication?
yes
id
188755e3-6ddf-40f9-8514-cf51986b7141
date added to LUP
2024-02-28 15:44:11
date last changed
2024-04-27 14:20:16
@article{188755e3-6ddf-40f9-8514-cf51986b7141,
  abstract     = {{<p>Introduction: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclinical cardiovascular disease. Methods: Ninety-two cardiovascular proteins were measured in 57 childhood cancer survivors and in 52 controls. For proteins that were significantly different between childhood cancer survivors and controls, we performed correlations between protein levels and measures of peripheral arterial stiffness (carotid distensibility and stiffness index, and augmentation index) and endothelial dysfunction (reactive hyperemia index). Results: Leptin was significantly higher in childhood cancer survivors compared to controls (normalized protein expression units: childhood cancer survivors 6.4 (1.5) versus 5.1 (1.7), p &lt; 0.0000001) after taking multiple tests into account. Kidney injury molecule-1, MER proto-oncogene tyrosine kinase, selectin P ligand, decorin, alpha-1-microglobulin/bikunin precursor protein, and pentraxin 3 showed a trend towards group differences (p &lt; 0.05). Among childhood cancer survivors, leptin was associated with anthracycline treatment after adjustment for age, sex, and body mass index (p &lt; 0.0001). Higher leptin correlated with lower carotid distensibility after adjustment for age, sex, body mass index, and treatments with radiotherapy and anthracyclines (p = 0.005). Conclusion: This proteomics approach identified that leptin is higher in young asymptomatic adult survivors of childhood cancer than in healthy controls and is associated with adverse vascular changes. This could indicate a role for leptin in driving the cardiovascular disease burden in this population.</p>}},
  author       = {{Broberg, Olof and Feldreich, Tobias and Weismann, Constance G. and Øra, Ingrid and Wiebe, Thomas and Ärnlöv, Johan and Liuba, Petru}},
  issn         = {{1047-9511}},
  keywords     = {{biomarker; cardiotoxicity; childhood cancer survivors; leptin; vasculotoxicity}},
  language     = {{eng}},
  publisher    = {{Cambridge University Press}},
  series       = {{Cardiology in the Young}},
  title        = {{Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer}},
  url          = {{http://dx.doi.org/10.1017/S1047951124000076}},
  doi          = {{10.1017/S1047951124000076}},
  year         = {{2024}},
}