Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

β cell function and insulin resistance have gender-specific correlations with carotid intima-media thickness in type 2 diabetes

Lu, Weifeng ; Wang, Kai ; Luo, Xiumei ; Zhang, Silan ; Zhou, Jingqi ; Li, Shangjian ; Chen, Ning and Luan, Cheng LU (2023) In International Journal of Diabetes in Developing Countries
Abstract
Objective
The relationships between carotid intima-media thickness (C-IMT) and β cell function and insulin resistance in patients with type 2 diabetes (T2D) have not been fully elucidated. This study is to investigate whether impaired glucose metabolism is etiologically associated with C-IMT in patients with T2D.

Methods
The study group consisted of 490 (284 men, 206 women) participants. Venous blood specimens were obtained from all subjects for biochemical profiles after an >8-h overnight fast. C-IMT was measured as the distance between the luminal-intimal leading edge (I-line) and the medial-adventitial leading edge (M-line) on the far wall. Insulin resistance was estimated with the homeostasis model assessment of... (More)
Objective
The relationships between carotid intima-media thickness (C-IMT) and β cell function and insulin resistance in patients with type 2 diabetes (T2D) have not been fully elucidated. This study is to investigate whether impaired glucose metabolism is etiologically associated with C-IMT in patients with T2D.

Methods
The study group consisted of 490 (284 men, 206 women) participants. Venous blood specimens were obtained from all subjects for biochemical profiles after an >8-h overnight fast. C-IMT was measured as the distance between the luminal-intimal leading edge (I-line) and the medial-adventitial leading edge (M-line) on the far wall. Insulin resistance was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). The acute insulin response to arginine was calculated as the mean of the three plasma insulin levels obtained within 2, 4, and 6 min after the arginine bolus minus the pre-stimulus plasma insulin levels.

Results
There was a graded increase in C-IMT values according to tertiles of HOMA-IR in men; the values of C-IMT were significantly decreased across the tertiles of acute insulin and C-peptide responses in women. Multivariate analysis revealed that HOMA-IR and age were positively associated with C-IMT among men participants, and acute insulin response and current smoking were the independent determinants of C-IMT in women.

Conclusion
Early insulin response stimulated by arginine is independently associated with C-IMT in women T2D individuals, whereas insulin resistance is positively correlated with C-IMT in men T2D subjects. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
β cell function, insulin resistance, Carotid Intima-Media Thickness, Type 2 diabetes
in
International Journal of Diabetes in Developing Countries
publisher
Springer
external identifiers
  • scopus:85173932045
ISSN
0973-3930
DOI
10.1007/s13410-023-01260-x
language
English
LU publication?
yes
id
18bb25ba-d593-4628-9172-53a6bb99892a
date added to LUP
2023-10-09 11:05:55
date last changed
2023-12-27 14:08:17
@article{18bb25ba-d593-4628-9172-53a6bb99892a,
  abstract     = {{Objective<br/>The relationships between carotid intima-media thickness (C-IMT) and β cell function and insulin resistance in patients with type 2 diabetes (T2D) have not been fully elucidated. This study is to investigate whether impaired glucose metabolism is etiologically associated with C-IMT in patients with T2D.<br/><br/>Methods<br/>The study group consisted of 490 (284 men, 206 women) participants. Venous blood specimens were obtained from all subjects for biochemical profiles after an &gt;8-h overnight fast. C-IMT was measured as the distance between the luminal-intimal leading edge (I-line) and the medial-adventitial leading edge (M-line) on the far wall. Insulin resistance was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). The acute insulin response to arginine was calculated as the mean of the three plasma insulin levels obtained within 2, 4, and 6 min after the arginine bolus minus the pre-stimulus plasma insulin levels.<br/><br/>Results<br/>There was a graded increase in C-IMT values according to tertiles of HOMA-IR in men; the values of C-IMT were significantly decreased across the tertiles of acute insulin and C-peptide responses in women. Multivariate analysis revealed that HOMA-IR and age were positively associated with C-IMT among men participants, and acute insulin response and current smoking were the independent determinants of C-IMT in women.<br/><br/>Conclusion<br/>Early insulin response stimulated by arginine is independently associated with C-IMT in women T2D individuals, whereas insulin resistance is positively correlated with C-IMT in men T2D subjects.}},
  author       = {{Lu, Weifeng and Wang, Kai and Luo, Xiumei and Zhang, Silan and Zhou, Jingqi and Li, Shangjian and Chen, Ning and Luan, Cheng}},
  issn         = {{0973-3930}},
  keywords     = {{β cell function; insulin resistance; Carotid Intima-Media Thickness; Type 2 diabetes}},
  language     = {{eng}},
  month        = {{10}},
  publisher    = {{Springer}},
  series       = {{International Journal of Diabetes in Developing Countries}},
  title        = {{β cell function and insulin resistance have gender-specific correlations with carotid intima-media thickness in type 2 diabetes}},
  url          = {{https://lup.lub.lu.se/search/files/160720512/s13410_023_01260_x.pdf}},
  doi          = {{10.1007/s13410-023-01260-x}},
  year         = {{2023}},
}