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Does uterine preservation affect survival outcomes of patients with stage I ovarian sex cord-stromal cell tumours? A multi-institutional study

Yoshihara, Masato ; Tamauchi, Satoshi ; Iyoshi, Shohei ; Kitami, Kazuhisa ; Uno, Kaname LU orcid ; Yoshikawa, Nobuhisa ; Ikeda, Yoshiki ; Kawai, Michiyasu ; Nagasaka, Tetsuro and Kajiyama, Hiroaki (2020) In European Journal of Obstetrics and Gynecology and Reproductive Biology 254. p.52-56
Abstract

Objective: Sex cord-stromal tumours of the ovary are relatively uncommon neoplasms that account for 3 % of all ovarian cancers. Uterine preservation with careful staging is achievable; however, conservative surgery remains controversial. This study examined the prognostic effects of uterine preservation in patients with stage I sex cord-stromal tumours. Study design: This retrospective cohort study was undertaken between January 1986 and February 2019, and the clinicopathological data of 4897 women with malignant ovarian tumours were collected. Seventy-seven patients with stage I sex cord-stromal tumours were eligible for inclusion. The characteristics and survival outcomes of these patients were examined. To investigate the prognostic... (More)

Objective: Sex cord-stromal tumours of the ovary are relatively uncommon neoplasms that account for 3 % of all ovarian cancers. Uterine preservation with careful staging is achievable; however, conservative surgery remains controversial. This study examined the prognostic effects of uterine preservation in patients with stage I sex cord-stromal tumours. Study design: This retrospective cohort study was undertaken between January 1986 and February 2019, and the clinicopathological data of 4897 women with malignant ovarian tumours were collected. Seventy-seven patients with stage I sex cord-stromal tumours were eligible for inclusion. The characteristics and survival outcomes of these patients were examined. To investigate the prognostic effects of uterine-preserving surgery, baseline imbalances between patients with and without uterine-preserving surgery were adjusted using an inverse probability of treatment weighting with propensity scores composed of independent clinical variables. Results: The mean ages of patients in the uterine-preserving surgery and non-uterine-preserving surgery groups were 39.8 and 57.8 years, respectively. After inverse probability of treatment weighting adjustments, no significant differences in overall survival (p = 0.205) or recurrence-free survival (p=0.071) were observed between the uterine-preserving surgery and non-uterine-preserving surgery groups. Estimated 10-year overall survival rates were 98.7 % in the uterine-preserving surgery group and 95.9 % in the non-uterine-preserving surgery group, and 10-year recurrence-free survival rates were 87.2 % in the uterine-preserving surgery group and 78.2 % in the non-uterine-preserving surgery group. Uterine-preserving surgery did not significantly affect the site of tumour recurrence. Conclusion: Uterine-preserving surgery may be a feasible surgical option for patients with stage I sex cord-stromal tumours. Further research is needed to guarantee prognostic accuracy and develop effective therapeutic approaches for sex cord-stromal tumours.

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; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hysterectomy, Inverse probability weighting, Ovarian neoplasm, Propensity score, Sex cord-stromal tumours
in
European Journal of Obstetrics and Gynecology and Reproductive Biology
volume
254
pages
5 pages
publisher
Elsevier
external identifiers
  • pmid:32947142
  • scopus:85090716475
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2020.09.009
language
English
LU publication?
yes
id
18d3d2e3-1d64-4954-88d3-7b5af0d9da4a
date added to LUP
2020-09-30 10:08:54
date last changed
2024-04-03 15:22:34
@article{18d3d2e3-1d64-4954-88d3-7b5af0d9da4a,
  abstract     = {{<p>Objective: Sex cord-stromal tumours of the ovary are relatively uncommon neoplasms that account for 3 % of all ovarian cancers. Uterine preservation with careful staging is achievable; however, conservative surgery remains controversial. This study examined the prognostic effects of uterine preservation in patients with stage I sex cord-stromal tumours. Study design: This retrospective cohort study was undertaken between January 1986 and February 2019, and the clinicopathological data of 4897 women with malignant ovarian tumours were collected. Seventy-seven patients with stage I sex cord-stromal tumours were eligible for inclusion. The characteristics and survival outcomes of these patients were examined. To investigate the prognostic effects of uterine-preserving surgery, baseline imbalances between patients with and without uterine-preserving surgery were adjusted using an inverse probability of treatment weighting with propensity scores composed of independent clinical variables. Results: The mean ages of patients in the uterine-preserving surgery and non-uterine-preserving surgery groups were 39.8 and 57.8 years, respectively. After inverse probability of treatment weighting adjustments, no significant differences in overall survival (p = 0.205) or recurrence-free survival (p=0.071) were observed between the uterine-preserving surgery and non-uterine-preserving surgery groups. Estimated 10-year overall survival rates were 98.7 % in the uterine-preserving surgery group and 95.9 % in the non-uterine-preserving surgery group, and 10-year recurrence-free survival rates were 87.2 % in the uterine-preserving surgery group and 78.2 % in the non-uterine-preserving surgery group. Uterine-preserving surgery did not significantly affect the site of tumour recurrence. Conclusion: Uterine-preserving surgery may be a feasible surgical option for patients with stage I sex cord-stromal tumours. Further research is needed to guarantee prognostic accuracy and develop effective therapeutic approaches for sex cord-stromal tumours.</p>}},
  author       = {{Yoshihara, Masato and Tamauchi, Satoshi and Iyoshi, Shohei and Kitami, Kazuhisa and Uno, Kaname and Yoshikawa, Nobuhisa and Ikeda, Yoshiki and Kawai, Michiyasu and Nagasaka, Tetsuro and Kajiyama, Hiroaki}},
  issn         = {{0301-2115}},
  keywords     = {{Hysterectomy; Inverse probability weighting; Ovarian neoplasm; Propensity score; Sex cord-stromal tumours}},
  language     = {{eng}},
  month        = {{11}},
  pages        = {{52--56}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Obstetrics and Gynecology and Reproductive Biology}},
  title        = {{Does uterine preservation affect survival outcomes of patients with stage I ovarian sex cord-stromal cell tumours? A multi-institutional study}},
  url          = {{http://dx.doi.org/10.1016/j.ejogrb.2020.09.009}},
  doi          = {{10.1016/j.ejogrb.2020.09.009}},
  volume       = {{254}},
  year         = {{2020}},
}