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Batch and Continuous Flow Production of 5-Hydroxymethylfurfural from a High Concentration of Fructose Using an Acidic Ion Exchange Catalyst

Pyo, Sang Hyun LU ; Sayed, Mahmoud LU and Hatti-Kaul, Rajni LU (2019) In Organic Process Research and Development 23(5). p.952-960
Abstract

5-Hydroxymethylfurfural (HMF), a product of catalytic dehydration of C6 sugars, is a versatile and key renewable platform chemical. The possibility to use a high substrate concentration with high yield in a single-solvent system is one of the solutions to reduce solvent usage, energy consumption, reaction volume, and operating cost. A heterogeneous catalyst and single-solvent system were employed to develop a facile and green process for the production of HMF from fructose at high concentration under moderate conditions in batch and continuous flow modes. In the batch process, with 0.1 and 0.2 w/w ion exchange resin DR-2030 as the catalyst, 98.8% fructose conversion with 82.2% HMF yield and 99.7% fructose conversion with 85% HMF yield,... (More)

5-Hydroxymethylfurfural (HMF), a product of catalytic dehydration of C6 sugars, is a versatile and key renewable platform chemical. The possibility to use a high substrate concentration with high yield in a single-solvent system is one of the solutions to reduce solvent usage, energy consumption, reaction volume, and operating cost. A heterogeneous catalyst and single-solvent system were employed to develop a facile and green process for the production of HMF from fructose at high concentration under moderate conditions in batch and continuous flow modes. In the batch process, with 0.1 and 0.2 w/w ion exchange resin DR-2030 as the catalyst, 98.8% fructose conversion with 82.2% HMF yield and 99.7% fructose conversion with 85% HMF yield, respectively, were obtained from 300 g/L (30% w/w) fructose in DMSO at 110 °C. The catalyst could be reused for at least five consecutive batches. Continuous dehydration of 300 g/L fructose was carried out at 110 °C in a simple flow reactor packed with the ion exchange resin. Fructose conversion of 98% and HMF yield of 82% were obtained. HMF was purified by liquid-liquid extraction, concentration, and silica chromatography.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
5-hydroxymethylfurfural (HMF), continuous flow dehydration, fructose, heterogeneous catalysis, ion exchange resin
in
Organic Process Research and Development
volume
23
issue
5
pages
9 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85065845639
ISSN
1083-6160
DOI
10.1021/acs.oprd.9b00044
project
STEPS – Sustainable Plastics and Transition Pathways
language
English
LU publication?
yes
id
18ebd576-209c-4d12-9bf3-e2746b4adce5
date added to LUP
2019-05-28 10:14:34
date last changed
2020-10-07 06:31:05
@article{18ebd576-209c-4d12-9bf3-e2746b4adce5,
  abstract     = {<p>5-Hydroxymethylfurfural (HMF), a product of catalytic dehydration of C6 sugars, is a versatile and key renewable platform chemical. The possibility to use a high substrate concentration with high yield in a single-solvent system is one of the solutions to reduce solvent usage, energy consumption, reaction volume, and operating cost. A heterogeneous catalyst and single-solvent system were employed to develop a facile and green process for the production of HMF from fructose at high concentration under moderate conditions in batch and continuous flow modes. In the batch process, with 0.1 and 0.2 w/w ion exchange resin DR-2030 as the catalyst, 98.8% fructose conversion with 82.2% HMF yield and 99.7% fructose conversion with 85% HMF yield, respectively, were obtained from 300 g/L (30% w/w) fructose in DMSO at 110 °C. The catalyst could be reused for at least five consecutive batches. Continuous dehydration of 300 g/L fructose was carried out at 110 °C in a simple flow reactor packed with the ion exchange resin. Fructose conversion of 98% and HMF yield of 82% were obtained. HMF was purified by liquid-liquid extraction, concentration, and silica chromatography.</p>},
  author       = {Pyo, Sang Hyun and Sayed, Mahmoud and Hatti-Kaul, Rajni},
  issn         = {1083-6160},
  language     = {eng},
  number       = {5},
  pages        = {952--960},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Organic Process Research and Development},
  title        = {Batch and Continuous Flow Production of 5-Hydroxymethylfurfural from a High Concentration of Fructose Using an Acidic Ion Exchange Catalyst},
  url          = {http://dx.doi.org/10.1021/acs.oprd.9b00044},
  doi          = {10.1021/acs.oprd.9b00044},
  volume       = {23},
  year         = {2019},
}