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The HSD17B13 rs72613567 variant is associated with lower levels of albuminuria in patients with biopsy-proven nonalcoholic fatty liver disease

Sun, Dan Qin ; Wang, Ting Yao ; Zheng, Kenneth I. ; Zhang, Hao Yang LU orcid ; Wang, Xiao Dong ; Targher, Giovanni ; Byrne, Christopher D. ; Chen, Yong Ping ; Yuan, Wei Jie and Jin, Yan , et al. (2021) In Nutrition, Metabolism and Cardiovascular Diseases 31(6). p.1822-1831
Abstract

Background and aims: Several susceptibility gene variants predisposing to nonalcoholic fatty liver disease (NAFLD) have been identified in chronic kidney disease (CKD). Evidence supports that 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) rs72613567 plays a role in NAFLD development by affecting lipid homeostasis. Since lipid droplets may accumulate in the kidneys and contribute to renal injury, we investigated the association between the HSD17B13 rs72613567 variant and markers of renal function/injury in NAFLD. Methods and results: We measured estimated glomerular filtration rate (eGFR), urinary/serum neutrophil gelatinase-associated lipocalin (NGAL), and urinary albumin-to-creatinine ratio (u-ACR) in individuals with biopsy-proven... (More)

Background and aims: Several susceptibility gene variants predisposing to nonalcoholic fatty liver disease (NAFLD) have been identified in chronic kidney disease (CKD). Evidence supports that 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) rs72613567 plays a role in NAFLD development by affecting lipid homeostasis. Since lipid droplets may accumulate in the kidneys and contribute to renal injury, we investigated the association between the HSD17B13 rs72613567 variant and markers of renal function/injury in NAFLD. Methods and results: We measured estimated glomerular filtration rate (eGFR), urinary/serum neutrophil gelatinase-associated lipocalin (NGAL), and urinary albumin-to-creatinine ratio (u-ACR) in individuals with biopsy-proven NAFLD. Multivariable regression analyses were undertaken to examine the associations between the HSD17B13 rs72613567 variant and markers of renal function/injury. Individuals were stratified by HSD17B13 rs72613567 genotypes into −/−, A/- and A/A groups. HSD17B13 rs72613567 genotypes were not significantly associated with eGFR and urinary/serum NGAL levels. Conversely, the prevalence of abnormal albuminuria in the A/- + A/A group was lower than in the −/− group (4.92% vs. 19.35%, p = 0.001). Additionally, the mean u-ACR levels were lower among carriers of the A/- or A/A genotypes with coexisting hypertension or diabetes, than among those with the −/− genotype. The risk of abnormal albuminuria (adjusted-odds ratio 0.16, p = 0.001) remained significantly lower in the A/- + A/A group after adjustment for established renal risk factors and histologic severity of NAFLD. Conclusion: HSD17B13 rs72613567: A allele is associated with a lower risk of having abnormal albuminuria, but not with lower eGFR or urinary/serum NGAL levels, in patients with biopsy-proven NAFLD.

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publishing date
type
Contribution to journal
publication status
published
keywords
17-Beta hydroxysteroid dehydrogenase 13, Albuminuria, Chronic kidney disease, Liver biopsy, Nonalcoholic fatty liver disease
in
Nutrition, Metabolism and Cardiovascular Diseases
volume
31
issue
6
pages
1822 - 1831
publisher
Elsevier
external identifiers
  • pmid:33853719
  • scopus:85103967862
ISSN
0939-4753
DOI
10.1016/j.numecd.2021.02.018
language
English
LU publication?
no
additional info
Funding Information: This work was supported by grants from the National Natural Science Foundation of China ( 82070588 , 82000690 ), High Level Creative Talents from Department of Public Health in Zhejiang Province ( S2032102600032 ), Project of New Century 551 Talent Nurturing in Wenzhou , Top Talent Support Program for Young and Middle-Age People of Wuxi Health Committee ( BJ2020026 ), Youth Research Project Fund from Wuxi Municipal Health Commission ( Q201932 ), Technology Development Fund in Wuxi ( N20202001 ) and Wuxi Youth Talent Fund ( QNRC075 ). GT is supported in part by grants from the School of Medicine, University of Verona , Verona, Italy. CDB is supported in part by the Southampton NIHR Biomedical Research Centre ( IS-BRC-20004 ), UK. Publisher Copyright: © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
id
18ee73a9-5cac-4bf0-adb7-fed905dfb6fb
date added to LUP
2024-02-05 15:42:06
date last changed
2024-04-21 23:57:35
@article{18ee73a9-5cac-4bf0-adb7-fed905dfb6fb,
  abstract     = {{<p>Background and aims: Several susceptibility gene variants predisposing to nonalcoholic fatty liver disease (NAFLD) have been identified in chronic kidney disease (CKD). Evidence supports that 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) rs72613567 plays a role in NAFLD development by affecting lipid homeostasis. Since lipid droplets may accumulate in the kidneys and contribute to renal injury, we investigated the association between the HSD17B13 rs72613567 variant and markers of renal function/injury in NAFLD. Methods and results: We measured estimated glomerular filtration rate (eGFR), urinary/serum neutrophil gelatinase-associated lipocalin (NGAL), and urinary albumin-to-creatinine ratio (u-ACR) in individuals with biopsy-proven NAFLD. Multivariable regression analyses were undertaken to examine the associations between the HSD17B13 rs72613567 variant and markers of renal function/injury. Individuals were stratified by HSD17B13 rs72613567 genotypes into −/−, A/- and A/A groups. HSD17B13 rs72613567 genotypes were not significantly associated with eGFR and urinary/serum NGAL levels. Conversely, the prevalence of abnormal albuminuria in the A/- + A/A group was lower than in the −/− group (4.92% vs. 19.35%, p = 0.001). Additionally, the mean u-ACR levels were lower among carriers of the A/- or A/A genotypes with coexisting hypertension or diabetes, than among those with the −/− genotype. The risk of abnormal albuminuria (adjusted-odds ratio 0.16, p = 0.001) remained significantly lower in the A/- + A/A group after adjustment for established renal risk factors and histologic severity of NAFLD. Conclusion: HSD17B13 rs72613567: A allele is associated with a lower risk of having abnormal albuminuria, but not with lower eGFR or urinary/serum NGAL levels, in patients with biopsy-proven NAFLD.</p>}},
  author       = {{Sun, Dan Qin and Wang, Ting Yao and Zheng, Kenneth I. and Zhang, Hao Yang and Wang, Xiao Dong and Targher, Giovanni and Byrne, Christopher D. and Chen, Yong Ping and Yuan, Wei Jie and Jin, Yan and Zheng, Ming Hua}},
  issn         = {{0939-4753}},
  keywords     = {{17-Beta hydroxysteroid dehydrogenase 13; Albuminuria; Chronic kidney disease; Liver biopsy; Nonalcoholic fatty liver disease}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{1822--1831}},
  publisher    = {{Elsevier}},
  series       = {{Nutrition, Metabolism and Cardiovascular Diseases}},
  title        = {{The HSD17B13 rs72613567 variant is associated with lower levels of albuminuria in patients with biopsy-proven nonalcoholic fatty liver disease}},
  url          = {{http://dx.doi.org/10.1016/j.numecd.2021.02.018}},
  doi          = {{10.1016/j.numecd.2021.02.018}},
  volume       = {{31}},
  year         = {{2021}},
}