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Using Dental Register Information and Questionnaire Data to Assess Periodontitis in Large Cohort Studies

Persson, Peter LU orcid ; Bladh, Magnus ; Teleka, Stanley LU ; Milosavljevic, Aleksandar ; Gustafsson, Nils ; Jäghagen, Eva Levring LU ; Klinge, Björn ; De Silva, Kushan ; Vähäsarja, Niko LU and Buhlin, Kåre , et al. (2025) In Journal of Clinical Periodontology 52(11). p.1529-1539
Abstract

Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionnaire items, number of periodontal treatment procedures (PTP) in the Dental Health Register (DHR), and number of teeth with ≥ 6 mm probing depth in the Swedish Quality Register for Caries and Periodontal Disease (SKaPa) were evaluated as proxies for severe periodontitis. Stage III–IV periodontitis was the primary reference standard. Results: For... (More)

Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionnaire items, number of periodontal treatment procedures (PTP) in the Dental Health Register (DHR), and number of teeth with ≥ 6 mm probing depth in the Swedish Quality Register for Caries and Periodontal Disease (SKaPa) were evaluated as proxies for severe periodontitis. Stage III–IV periodontitis was the primary reference standard. Results: For PTP-based severe periodontitis proxy in DHR, positive predictive value (PPV) was 88% and negative predictive value (NPV) 87% for Stage III–IV. The SKaPa-based proxy showed poor positive predictive values (PPVs, < 70%), but similar area under the curve (AUC), 0.74, compared with the DHR data (AUC 0.76). Sensitivity was < 70%, and specificity > 90% for the DHR and SKaPa proxies. Identification of cases with periodontitis by questionnaire combined with the demographic variables age, sex, smoking habits and education yielded good discriminatory ability (AUC > 0.75). Conclusion: Register-based data can effectively identify individuals with severe periodontitis in large cohort studies, thereby advancing periodontal research.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dental Health Register, epidemiology, periodontitis, self-reported, Swedish Quality Register for Caries and Periodontal Disease
in
Journal of Clinical Periodontology
volume
52
issue
11
pages
11 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:105013770275
  • pmid:40827525
ISSN
0303-6979
DOI
10.1111/jcpe.70015
language
English
LU publication?
yes
id
18f5af9c-3994-4de0-8e47-1090c0f4bb10
date added to LUP
2025-11-19 09:21:34
date last changed
2026-01-14 14:15:48
@article{18f5af9c-3994-4de0-8e47-1090c0f4bb10,
  abstract     = {{<p>Aim: Periodontitis proxy variables enable an expansion of periodontal research. The study aimed to estimate the validity of questionnaire items and registry data in relation to Stage III–IV periodontitis and having 50% bone loss. Methods: Malmö Offspring Dental Study (MODS) participants (995) filled out questionnaires and underwent periodontal and panoramic radiography examinations. The questionnaire items, number of periodontal treatment procedures (PTP) in the Dental Health Register (DHR), and number of teeth with ≥ 6 mm probing depth in the Swedish Quality Register for Caries and Periodontal Disease (SKaPa) were evaluated as proxies for severe periodontitis. Stage III–IV periodontitis was the primary reference standard. Results: For PTP-based severe periodontitis proxy in DHR, positive predictive value (PPV) was 88% and negative predictive value (NPV) 87% for Stage III–IV. The SKaPa-based proxy showed poor positive predictive values (PPVs, &lt; 70%), but similar area under the curve (AUC), 0.74, compared with the DHR data (AUC 0.76). Sensitivity was &lt; 70%, and specificity &gt; 90% for the DHR and SKaPa proxies. Identification of cases with periodontitis by questionnaire combined with the demographic variables age, sex, smoking habits and education yielded good discriminatory ability (AUC &gt; 0.75). Conclusion: Register-based data can effectively identify individuals with severe periodontitis in large cohort studies, thereby advancing periodontal research.</p>}},
  author       = {{Persson, Peter and Bladh, Magnus and Teleka, Stanley and Milosavljevic, Aleksandar and Gustafsson, Nils and Jäghagen, Eva Levring and Klinge, Björn and De Silva, Kushan and Vähäsarja, Niko and Buhlin, Kåre and Nilsson, Peter and Orho-Melander, Marju and Melander, Olle and Naimi-Akbar, Aron and Jönsson, Daniel}},
  issn         = {{0303-6979}},
  keywords     = {{Dental Health Register; epidemiology; periodontitis; self-reported; Swedish Quality Register for Caries and Periodontal Disease}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1529--1539}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Clinical Periodontology}},
  title        = {{Using Dental Register Information and Questionnaire Data to Assess Periodontitis in Large Cohort Studies}},
  url          = {{http://dx.doi.org/10.1111/jcpe.70015}},
  doi          = {{10.1111/jcpe.70015}},
  volume       = {{52}},
  year         = {{2025}},
}