Oxidative Stress and Its Biomarkers in Cardiovascular Diseases
Valaitienė, Julija and Laučytė-Cibulskienė, Agnė LU
(2024)
In Artery Research
30(1).
- Abstract
Background: Cardiovascular diseases (CVDs) are the most common cause of death worldwide. CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. Main Body: Surplus levels of reactive oxygen species induce damage to cellular macromolecules such as DNA, proteins, and lipids. Increased reactive oxygen species result in decreased nitric oxide availability, vasoconstriction, and the development of procoagulant and proinflammatory states in blood vessels. Conclusion: Improved knowledge of biomolecular processes triggered by oxidative stress has helped develop tools for assessing oxidative stress markers and applying them in clinical settings. Nevertheless, some research gaps should be filled,... (More)
Background: Cardiovascular diseases (CVDs) are the most common cause of death worldwide. CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. Main Body: Surplus levels of reactive oxygen species induce damage to cellular macromolecules such as DNA, proteins, and lipids. Increased reactive oxygen species result in decreased nitric oxide availability, vasoconstriction, and the development of procoagulant and proinflammatory states in blood vessels. Conclusion: Improved knowledge of biomolecular processes triggered by oxidative stress has helped develop tools for assessing oxidative stress markers and applying them in clinical settings. Nevertheless, some research gaps should be filled, specifically by defining the most clinically relevant biomarkers for oxidative stress with high sensitivity and specificity for CVD.
(Less)
- author
- Valaitienė, Julija
and Laučytė-Cibulskienė, Agnė
LU
- organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biomarkers, Cardiovascular diseases, Endothelial cell dysfunction, Inflammation, Oxidative stress, Reactive oxygen species
- in
- Artery Research
- volume
- 30
- issue
- 1
- article number
- 18
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85208244239
- ISSN
- 1872-9312
- DOI
- 10.1007/s44200-024-00062-8
- language
- English
- LU publication?
- yes
- id
- 1901c262-2104-49c7-852e-d587348a6fc8
- date added to LUP
- 2024-12-04 09:38:11
- date last changed
- 2025-04-04 14:38:12
@article{1901c262-2104-49c7-852e-d587348a6fc8,
abstract = {{<p>Background: Cardiovascular diseases (CVDs) are the most common cause of death worldwide. CVDs share heterogeneous pathophysiologic mechanisms, one of which includes increased oxidative stress. Main Body: Surplus levels of reactive oxygen species induce damage to cellular macromolecules such as DNA, proteins, and lipids. Increased reactive oxygen species result in decreased nitric oxide availability, vasoconstriction, and the development of procoagulant and proinflammatory states in blood vessels. Conclusion: Improved knowledge of biomolecular processes triggered by oxidative stress has helped develop tools for assessing oxidative stress markers and applying them in clinical settings. Nevertheless, some research gaps should be filled, specifically by defining the most clinically relevant biomarkers for oxidative stress with high sensitivity and specificity for CVD.</p>}},
author = {{Valaitienė, Julija and Laučytė-Cibulskienė, Agnė}},
issn = {{1872-9312}},
keywords = {{Biomarkers; Cardiovascular diseases; Endothelial cell dysfunction; Inflammation; Oxidative stress; Reactive oxygen species}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Artery Research}},
title = {{Oxidative Stress and Its Biomarkers in Cardiovascular Diseases}},
url = {{http://dx.doi.org/10.1007/s44200-024-00062-8}},
doi = {{10.1007/s44200-024-00062-8}},
volume = {{30}},
year = {{2024}},
}