Particle sizing and biokinetics of interstitiallymphoscintigraphic agents
Bergqvist, Lennart LU ; Strand, Sven Erik LU and Persson, Bertil R.R. LU
(1983)
In Seminars in Nuclear Medicine
13(1).
p.9-19
- Abstract
The biokinetics of inert lymphoscintigraphic agentsstrongly depends on their particle size. Different techniques for characterization of colloids are discussed. Experiments have been performed on eight different colloids. The particle size has been investigated with scanning electron microscopy. Activity distributions have been obtained with ultrafiltration and gel-column scanning technique. The colloids suggested for lymphoscintigraphy were found to have a median size of about 40-50 nm except one minimicro-aggregated human serum albumin colloid which has a median particle size around 10 nm. The biokinetics were studied with a scintillation camera in rabbits after a subcutaneous injection. Timeactivity curves were generated. After 5 hr... (More)
The biokinetics of inert lymphoscintigraphic agentsstrongly depends on their particle size. Different techniques for characterization of colloids are discussed. Experiments have been performed on eight different colloids. The particle size has been investigated with scanning electron microscopy. Activity distributions have been obtained with ultrafiltration and gel-column scanning technique. The colloids suggested for lymphoscintigraphy were found to have a median size of about 40-50 nm except one minimicro-aggregated human serum albumin colloid which has a median particle size around 10 nm. The biokinetics were studied with a scintillation camera in rabbits after a subcutaneous injection. Timeactivity curves were generated. After 5 hr the rabbits were dissected and the activity content in different tissues measured. A compartment model for the biokinetics was designed and rate constants evaluated. The total and specific activity uptake in parasternal lymph nodes was highest for the small-particle colloids. The compartment model showed a good fitting to the experimental data.
(Less)
- author
- Bergqvist, Lennart
LU
; Strand, Sven Erik
LU
and Persson, Bertil R.R.
LU
- organization
- publishing date
- 1983-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Seminars in Nuclear Medicine
- volume
- 13
- issue
- 1
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:6220471
- scopus:0020669521
- ISSN
- 0001-2998
- DOI
- 10.1016/S0001-2998(83)80031-2
- language
- English
- LU publication?
- yes
- id
- 191a57d4-0cfd-44ca-97a9-d5a4f7bcd6eb
- date added to LUP
- 2020-05-07 21:28:07
- date last changed
- 2024-04-03 06:13:07
@article{191a57d4-0cfd-44ca-97a9-d5a4f7bcd6eb,
abstract = {{<p>The biokinetics of inert lymphoscintigraphic agentsstrongly depends on their particle size. Different techniques for characterization of colloids are discussed. Experiments have been performed on eight different colloids. The particle size has been investigated with scanning electron microscopy. Activity distributions have been obtained with ultrafiltration and gel-column scanning technique. The colloids suggested for lymphoscintigraphy were found to have a median size of about 40-50 nm except one minimicro-aggregated human serum albumin colloid which has a median particle size around 10 nm. The biokinetics were studied with a scintillation camera in rabbits after a subcutaneous injection. Timeactivity curves were generated. After 5 hr the rabbits were dissected and the activity content in different tissues measured. A compartment model for the biokinetics was designed and rate constants evaluated. The total and specific activity uptake in parasternal lymph nodes was highest for the small-particle colloids. The compartment model showed a good fitting to the experimental data.</p>}},
author = {{Bergqvist, Lennart and Strand, Sven Erik and Persson, Bertil R.R.}},
issn = {{0001-2998}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{9--19}},
publisher = {{Elsevier}},
series = {{Seminars in Nuclear Medicine}},
title = {{Particle sizing and biokinetics of interstitiallymphoscintigraphic agents}},
url = {{http://dx.doi.org/10.1016/S0001-2998(83)80031-2}},
doi = {{10.1016/S0001-2998(83)80031-2}},
volume = {{13}},
year = {{1983}},
}