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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Schunkert, Heribert; Koenig, Inke R.; Kathiresan, Sekar; Reilly, Muredach P.; Assimes, Themistocles L.; Holm, Hilma; Preuss, Michael; Stewart, Alexandre F. R.; Barbalic, Maja and Gieger, Christian, et al. (2011) In Nature Genetics 43(4). p.153-333
Abstract
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the... (More)
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits. (Less)
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Nature Genetics
volume
43
issue
4
pages
153 - 333
publisher
Nature Publishing Group
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  • wos:000288903700013
  • scopus:79953204259
ISSN
1546-1718
DOI
10.1038/ng.784
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English
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yes
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7553dae4-0464-42ca-8c45-78d32d2b97af (old id 1925030)
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2011-05-02 10:29:30
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2017-11-19 03:49:26
@article{7553dae4-0464-42ca-8c45-78d32d2b97af,
  abstract     = {We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P &lt; 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.},
  author       = {Schunkert, Heribert and Koenig, Inke R. and Kathiresan, Sekar and Reilly, Muredach P. and Assimes, Themistocles L. and Holm, Hilma and Preuss, Michael and Stewart, Alexandre F. R. and Barbalic, Maja and Gieger, Christian and Absher, Devin and Aherrahrou, Zouhair and Allayee, Hooman and Altshuler, David and Anand, Sonia S. and Andersen, Karl and Anderson, Jeffrey L. and Ardissino, Diego and Ball, Stephen G. and Balmforth, Anthony J. and Barnes, Timothy A. and Becker, Diane M. and Becker, Lewis C. and Berger, Klaus and Bis, Joshua C. and Boekholdt, S. Matthijs and Boerwinkle, Eric and Braund, Peter S. and Brown, Morris J. and Burnett, Mary Susan and Buysschaert, Ian and Carlquist, John F. and Chen, Li and Cichon, Sven and Codd, Veryan and Davies, Robert W. and Dedoussis, George and Dehghan, Abbas and Demissie, Serkalem and Devaney, Joseph M. and Diemert, Patrick and Do, Ron and Doering, Angela and Eifert, Sandra and El Mokhtari, Nour Eddine and Ellis, Stephen G. and Elosua, Roberto and Engert, James C. and Epstein, Stephen E. and de Faire, Ulf and Fischer, Marcus and Folsom, Aaron R. and Freyer, Jennifer and Gigante, Bruna and Girelli, Domenico and Gretarsdottir, Solveig and Gudnason, Vilmundur and Gulcher, Jeffrey R. and Halperin, Eran and Hammond, Naomi and Hazen, Stanley L. and Hofman, Albert and Horne, Benjamin D. and Illig, Thomas and Iribarren, Carlos and Jones, Gregory T. and Jukema, J. Wouter and Kaiser, Michael A. and Kaplan, Lee M. and Kastelein, John J. P. and Khaw, Kay-Tee and Knowles, Joshua W. and Kolovou, Genovefa and Kong, Augustine and Laaksonen, Reijo and Lambrechts, Diether and Leander, Karin and Lettre, Guillaume and Li, Mingyao and Lieb, Wolfgang and Loley, Christina and Lotery, Andrew J. and Mannucci, Pier M. and Maouche, Seraya and Martinelli, Nicola and McKeown, Pascal P. and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Merlini, Pier Angelica and Mooser, Vincent and Morgan, Thomas and Muehleisen, Thomas W. and Muhlestein, Joseph B. and Muenzel, Thomas and Musunuru, Kiran and nahrstaedt, Janja and Nelson, Christopher P. and Noethen, Markus M. and Olivieri, Oliviero and Patel, Riyaz S. and Patterson, Chris C. and Peters, Annette and Peyvandi, Flora and Qu, Liming and Quyyumi, Arshed A. and Rader, Daniel J. and Rallidis, Loukianos S. and Rice, Catherine and Rosendaal, Frits R. and Rubin, Diana and Salomaa, Veikko and Sampietro, M. Lourdes and Sandhu, Manj S. and Schadt, Eric and Schaefer, Arne and Schillert, Arne and Schreiber, Stefan and Schrezenmeir, Juergen and Schwartz, Stephen M. and Siscovick, David S. and Sivananthan, Mohan and Sivapalaratnam, Suthesh and Smith, Albert and Smith, Tamara B. and Snoep, Jaapjan D. and Soranzo, Nicole and Spertus, John A. and Stark, Klaus and Stirrups, Kathy and Stoll, Monika and Tang, W. H. Wilson and Tennstedt, Stephanie and Thorgeirsson, Gudmundur and Thorleifsson, Gudmar and Tomaszewski, Maciej and Uitterlinden, Andre G. and van Rij, Andre M. and Voight, Benjamin F. and Wareham, Nick J. and Wells, George A. and Wichmann, H-Erich and Wild, Philipp S. and Willenborg, Christina and Witteman, Jaqueline C. M. and Wright, Benjamin J. and Ye, Shu and Zeller, Tanja and Ziegler, Andreas and Cambien, Francois and Goodall, Alison H. and Cupples, L. Adrienne and Quertermous, Thomas and Maerz, Winfried and Hengstenberg, Christian and Blankenberg, Stefan and Ouwehand, Willem H. and Hall, Alistair S. and Deloukas, Panos and Thompson, John R. and Stefansson, Kari and Roberts, Robert and Thorsteinsdottir, Unnur and O'Donnell, Christopher J. and McPherson, Ruth and Erdmann, Jeanette and Samani, Nilesh J.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {4},
  pages        = {153--333},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease},
  url          = {http://dx.doi.org/10.1038/ng.784},
  volume       = {43},
  year         = {2011},
}