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Two icodextrin exchanges per day in peritoneal dialysis patients with ultrafiltration failure: one center's experience and review of the literature

Dousdampanis, Periklis; Trigka, Konstantza; Chu, Maggie; Khan, Saimah; Venturoli, Daniele LU ; Oreopoulos, Dimitrios G. and Bargman, Joanne M. (2011) In International Urology and Nephrology 43(1). p.203-209
Abstract
At present, only one exchange of an icodextrin-based solution is recommended to increase peritoneal ultrafiltration (UF) during long-dwell exchanges in peritoneal dialysis (PD) patients with impaired UF. To review our experience with two icodextrin exchanges per day on net UF and body weight in PD patients with poor UF. Data were analyzed on nine patients with poor UF on chronic PD who were given two icodextrin exchanges per day for 6 months and had various clinical and biochemical parameters assessed monthly. Administration of icodextrin twice daily reduced the body weight in six of nine patients by an average of 2.9 +/- A 1.2 kg, a reduction that was maintained throughout the study; two patients gained 0.5 kg; and, in one patient, the... (More)
At present, only one exchange of an icodextrin-based solution is recommended to increase peritoneal ultrafiltration (UF) during long-dwell exchanges in peritoneal dialysis (PD) patients with impaired UF. To review our experience with two icodextrin exchanges per day on net UF and body weight in PD patients with poor UF. Data were analyzed on nine patients with poor UF on chronic PD who were given two icodextrin exchanges per day for 6 months and had various clinical and biochemical parameters assessed monthly. Administration of icodextrin twice daily reduced the body weight in six of nine patients by an average of 2.9 +/- A 1.2 kg, a reduction that was maintained throughout the study; two patients gained 0.5 kg; and, in one patient, the measurements were inadequate. Mean blood pressure was reduced. Mean serum creatinine increased slightly. Serum sodium levels decreased from a mean baseline level of 134 +/- A 3 to 132 +/- A 4 mmol/L at three and six months. Among the diabetics in this group, average daily insulin requirements were 44 +/- A 35 units/day at baseline and 40 +/- A 23 units/day after 6 months. Hb1Ac levels remained stable throughout the study period. The use of two icodextrin exchanges per day reduced body weight in six of the nine patients and appeared to be safe. Long-term prospective studies are needed to assess the contribution of twice-daily icodextrin to the management of peritoneal dialysis patients with ultrafiltration failure and its long-term safety. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Computer simulations, Dextrose solutions, Icodextrin, Peritoneal, dialysis, Ultrafiltration failure
in
International Urology and Nephrology
volume
43
issue
1
pages
203 - 209
publisher
Akademiai Kiado
external identifiers
  • wos:000288558900027
  • scopus:79953818842
ISSN
1573-2584
DOI
10.1007/s11255-010-9716-9
language
English
LU publication?
yes
id
71f3aaa0-260a-42be-b1b3-38220198c6f2 (old id 1925901)
date added to LUP
2011-05-02 08:45:31
date last changed
2017-02-12 03:43:53
@article{71f3aaa0-260a-42be-b1b3-38220198c6f2,
  abstract     = {At present, only one exchange of an icodextrin-based solution is recommended to increase peritoneal ultrafiltration (UF) during long-dwell exchanges in peritoneal dialysis (PD) patients with impaired UF. To review our experience with two icodextrin exchanges per day on net UF and body weight in PD patients with poor UF. Data were analyzed on nine patients with poor UF on chronic PD who were given two icodextrin exchanges per day for 6 months and had various clinical and biochemical parameters assessed monthly. Administration of icodextrin twice daily reduced the body weight in six of nine patients by an average of 2.9 +/- A 1.2 kg, a reduction that was maintained throughout the study; two patients gained 0.5 kg; and, in one patient, the measurements were inadequate. Mean blood pressure was reduced. Mean serum creatinine increased slightly. Serum sodium levels decreased from a mean baseline level of 134 +/- A 3 to 132 +/- A 4 mmol/L at three and six months. Among the diabetics in this group, average daily insulin requirements were 44 +/- A 35 units/day at baseline and 40 +/- A 23 units/day after 6 months. Hb1Ac levels remained stable throughout the study period. The use of two icodextrin exchanges per day reduced body weight in six of the nine patients and appeared to be safe. Long-term prospective studies are needed to assess the contribution of twice-daily icodextrin to the management of peritoneal dialysis patients with ultrafiltration failure and its long-term safety.},
  author       = {Dousdampanis, Periklis and Trigka, Konstantza and Chu, Maggie and Khan, Saimah and Venturoli, Daniele and Oreopoulos, Dimitrios G. and Bargman, Joanne M.},
  issn         = {1573-2584},
  keyword      = {Computer simulations,Dextrose solutions,Icodextrin,Peritoneal,dialysis,Ultrafiltration failure},
  language     = {eng},
  number       = {1},
  pages        = {203--209},
  publisher    = {Akademiai Kiado},
  series       = {International Urology and Nephrology},
  title        = {Two icodextrin exchanges per day in peritoneal dialysis patients with ultrafiltration failure: one center's experience and review of the literature},
  url          = {http://dx.doi.org/10.1007/s11255-010-9716-9},
  volume       = {43},
  year         = {2011},
}