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Assessing cerebrospinal fluid flow connectivity using 3D gradient echo phase contrast velocity encoded MRI

Odeen, Henrik LU ; Uppman, Martin LU ; Markl, Michael and Spottiswoode, Bruce S. (2011) In Physiological Measurement 32(4). p.407-421
Abstract
The aim of this study is to investigate the feasibility of using three-directional velocity encoded 3D gradient echo (GE) phase contrast (PC) imaging to assess cerebrospinal fluid (CSF) flow connectivity in the human brain. Five healthy volunteers were scanned using low velocity sensitivity (V-enc = 0.04-0.05 m s(-1)). Flow-time curves were compared to standard 2D PC scans. The 3D data were used to reconstruct in vivo CSF flow volumes based on time-averaged phase-difference information, and the patency of the CSF flow pathways was assessed using nearest-neighbour connectivity. A pulsatile flow phantom was used to gauge the measurement accuracy of the CSF flow volumes at low flow velocities. Flow connectivity from the lateral ventricles... (More)
The aim of this study is to investigate the feasibility of using three-directional velocity encoded 3D gradient echo (GE) phase contrast (PC) imaging to assess cerebrospinal fluid (CSF) flow connectivity in the human brain. Five healthy volunteers were scanned using low velocity sensitivity (V-enc = 0.04-0.05 m s(-1)). Flow-time curves were compared to standard 2D PC scans. The 3D data were used to reconstruct in vivo CSF flow volumes based on time-averaged phase-difference information, and the patency of the CSF flow pathways was assessed using nearest-neighbour connectivity. A pulsatile flow phantom was used to gauge the measurement accuracy of the CSF flow volumes at low flow velocities. Flow connectivity from the lateral ventricles down to the cisterna magna was successfully demonstrated in all volunteers. The phantom tests showed a good distinction between the flow cavities and the background noise. 3D PC imaging results in CSF flow waveforms with similar pulsatility but underestimated peak velocities compared to 2D PC data. 3D time-resolved velocity encoded GE imaging has successfully been applied to assess CSF flow connectivity in normal subjects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
phase contrast, velocity encoding, cerebrospinal fluid, angiography
in
Physiological Measurement
volume
32
issue
4
pages
407 - 421
publisher
IOP Publishing
external identifiers
  • wos:000288510700004
  • scopus:79952957837
ISSN
0967-3334
DOI
10.1088/0967-3334/32/4/003
language
English
LU publication?
yes
id
32560134-1f65-4efc-bcdf-78f821619241 (old id 1926443)
date added to LUP
2011-05-10 10:32:12
date last changed
2017-01-01 03:20:07
@article{32560134-1f65-4efc-bcdf-78f821619241,
  abstract     = {The aim of this study is to investigate the feasibility of using three-directional velocity encoded 3D gradient echo (GE) phase contrast (PC) imaging to assess cerebrospinal fluid (CSF) flow connectivity in the human brain. Five healthy volunteers were scanned using low velocity sensitivity (V-enc = 0.04-0.05 m s(-1)). Flow-time curves were compared to standard 2D PC scans. The 3D data were used to reconstruct in vivo CSF flow volumes based on time-averaged phase-difference information, and the patency of the CSF flow pathways was assessed using nearest-neighbour connectivity. A pulsatile flow phantom was used to gauge the measurement accuracy of the CSF flow volumes at low flow velocities. Flow connectivity from the lateral ventricles down to the cisterna magna was successfully demonstrated in all volunteers. The phantom tests showed a good distinction between the flow cavities and the background noise. 3D PC imaging results in CSF flow waveforms with similar pulsatility but underestimated peak velocities compared to 2D PC data. 3D time-resolved velocity encoded GE imaging has successfully been applied to assess CSF flow connectivity in normal subjects.},
  author       = {Odeen, Henrik and Uppman, Martin and Markl, Michael and Spottiswoode, Bruce S.},
  issn         = {0967-3334},
  keyword      = {phase contrast,velocity encoding,cerebrospinal fluid,angiography},
  language     = {eng},
  number       = {4},
  pages        = {407--421},
  publisher    = {IOP Publishing},
  series       = {Physiological Measurement},
  title        = {Assessing cerebrospinal fluid flow connectivity using 3D gradient echo phase contrast velocity encoded MRI},
  url          = {http://dx.doi.org/10.1088/0967-3334/32/4/003},
  volume       = {32},
  year         = {2011},
}