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Mild dementia is associated with increased adrenal secretion of cortisol and precursor sex steroids in women.

Johansson, Per LU ; Johansson, Jan-Ove; Labrie, Fernand; Mattsson, Niklas; Hansson, Oskar LU ; Blennow, Kaj; Zetterberg, Henrik; Wallin, Anders; Ohlsson, Claes and Svensson, Johan (2011) In Clinical Endocrinology 75. p.301-308
Abstract
Context: Sex steroid levels decrease with increasing age, but little is known whether this is of importance for the age-related decline in cognitive function. Design and Patients: A cross-sectional study of 50 (26 men) consecutive patients under primary evaluation of cognitive impairment (D group) and 18 (9 men) matched healthy controls (C group). Measurements: Sex steroid and precursor levels were determined in serum and when measurable, in cerebrospinal fluid (CSF) using gas chromatography/mass spectroscopy (GC-MS) or liquid chromatography/mass spectroscopy (LC-MS). Sex hormone binding globulin (SHBG) and cortisol concentrations were measured using conventional assays. Results: Patients in the D group had higher 24-h urine cortisol level... (More)
Context: Sex steroid levels decrease with increasing age, but little is known whether this is of importance for the age-related decline in cognitive function. Design and Patients: A cross-sectional study of 50 (26 men) consecutive patients under primary evaluation of cognitive impairment (D group) and 18 (9 men) matched healthy controls (C group). Measurements: Sex steroid and precursor levels were determined in serum and when measurable, in cerebrospinal fluid (CSF) using gas chromatography/mass spectroscopy (GC-MS) or liquid chromatography/mass spectroscopy (LC-MS). Sex hormone binding globulin (SHBG) and cortisol concentrations were measured using conventional assays. Results: Patients in the D group had higher 24-h urine cortisol level and increased serum levels of dehydroepiandrosterone (DHEA) and its sulfate ester DHEAS, androsterone (ADT), and estrone (E1) and its sulfate ester E1S, compared to the controls. When men and women were analyzed separately, increased serum concentrations of E1 and E1S were observed in both D men and D women whereas increased levels of other sex steroids and cortisol were seen only in D women. Conclusions: In both D men and women, serum E1 and E1S levels were increased whereas other changes were gender-specific and only seen in D women. Further studies are needed to determine whether these changes are a cause of, or merely a consequence of, cognitive impairment in elderly subjects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Endocrinology
volume
75
pages
301 - 308
publisher
Wiley-Blackwell
external identifiers
  • wos:000294256500006
  • pmid:21521348
  • scopus:79961212225
ISSN
1365-2265
DOI
10.1111/j.1365-2265.2011.04082.x
language
English
LU publication?
yes
id
eba85ab7-1f41-489e-9966-c43c10455419 (old id 1936681)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21521348?dopt=Abstract
date added to LUP
2011-05-02 16:35:31
date last changed
2017-01-01 07:37:51
@article{eba85ab7-1f41-489e-9966-c43c10455419,
  abstract     = {Context: Sex steroid levels decrease with increasing age, but little is known whether this is of importance for the age-related decline in cognitive function. Design and Patients: A cross-sectional study of 50 (26 men) consecutive patients under primary evaluation of cognitive impairment (D group) and 18 (9 men) matched healthy controls (C group). Measurements: Sex steroid and precursor levels were determined in serum and when measurable, in cerebrospinal fluid (CSF) using gas chromatography/mass spectroscopy (GC-MS) or liquid chromatography/mass spectroscopy (LC-MS). Sex hormone binding globulin (SHBG) and cortisol concentrations were measured using conventional assays. Results: Patients in the D group had higher 24-h urine cortisol level and increased serum levels of dehydroepiandrosterone (DHEA) and its sulfate ester DHEAS, androsterone (ADT), and estrone (E1) and its sulfate ester E1S, compared to the controls. When men and women were analyzed separately, increased serum concentrations of E1 and E1S were observed in both D men and D women whereas increased levels of other sex steroids and cortisol were seen only in D women. Conclusions: In both D men and women, serum E1 and E1S levels were increased whereas other changes were gender-specific and only seen in D women. Further studies are needed to determine whether these changes are a cause of, or merely a consequence of, cognitive impairment in elderly subjects.},
  author       = {Johansson, Per and Johansson, Jan-Ove and Labrie, Fernand and Mattsson, Niklas and Hansson, Oskar and Blennow, Kaj and Zetterberg, Henrik and Wallin, Anders and Ohlsson, Claes and Svensson, Johan},
  issn         = {1365-2265},
  language     = {eng},
  pages        = {301--308},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Endocrinology},
  title        = {Mild dementia is associated with increased adrenal secretion of cortisol and precursor sex steroids in women.},
  url          = {http://dx.doi.org/10.1111/j.1365-2265.2011.04082.x},
  volume       = {75},
  year         = {2011},
}