Biochemical diagnosis of primary hyperparathyroidism: Analysis of the sensitivity of total and ionized calcium in combination with PTH.
(2011) In Clinical Biochemistry 44. p.849-852- Abstract
- OBJECTIVES: To investigate the accuracy of the biochemical diagnosis of primary hyperparathyroidism (pHPT) in a consecutive series of patients with operatively verified disease. DESIGN AND SUBJECTS: Four hundred thirty-six patients with pHPT, 340 women and 96 men, were reviewed. Biochemical variables, including total calcium (Ca), ionized calcium (Cai) and PTH were analyzed and registered in a prospective database. RESULTS: In the subgroup of patients with more mild hypercalcemia (Ca below 2.70mmol/L) the correlation between Ca and Cai was poor. 19 respectively 18 patients had preoperatively a Ca respectively Cai level within the reference range. Further 35 patients had preoperatively a normal level of PTH. The diagnostic sensitivities for... (More)
- OBJECTIVES: To investigate the accuracy of the biochemical diagnosis of primary hyperparathyroidism (pHPT) in a consecutive series of patients with operatively verified disease. DESIGN AND SUBJECTS: Four hundred thirty-six patients with pHPT, 340 women and 96 men, were reviewed. Biochemical variables, including total calcium (Ca), ionized calcium (Cai) and PTH were analyzed and registered in a prospective database. RESULTS: In the subgroup of patients with more mild hypercalcemia (Ca below 2.70mmol/L) the correlation between Ca and Cai was poor. 19 respectively 18 patients had preoperatively a Ca respectively Cai level within the reference range. Further 35 patients had preoperatively a normal level of PTH. The diagnostic sensitivities for Ca, Cai and the combination of Ca and Cai were 96%, 96% and 99%. CONCLUSION: If calcium and ionized calcium are not used in the diagnostic workup of pHPT some 4% of the patients will be overlooked. We recommend analyzing both Ca and Cai in the diagnostic workup of pHPT. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1936806
- author
- Nordenström, Erik LU ; Katzman, Per LU and Bergenfelz, Anders LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Biochemistry
- volume
- 44
- pages
- 849 - 852
- publisher
- Elsevier
- external identifiers
-
- wos:000292074800020
- pmid:21515248
- scopus:79958807344
- pmid:21515248
- ISSN
- 1873-2933
- DOI
- 10.1016/j.clinbiochem.2011.04.002
- language
- English
- LU publication?
- yes
- id
- 4b6307b0-c5a4-41d1-8772-3817876d412b (old id 1936806)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21515248?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:08
- date last changed
- 2024-01-12 07:57:04
@article{4b6307b0-c5a4-41d1-8772-3817876d412b, abstract = {{OBJECTIVES: To investigate the accuracy of the biochemical diagnosis of primary hyperparathyroidism (pHPT) in a consecutive series of patients with operatively verified disease. DESIGN AND SUBJECTS: Four hundred thirty-six patients with pHPT, 340 women and 96 men, were reviewed. Biochemical variables, including total calcium (Ca), ionized calcium (Cai) and PTH were analyzed and registered in a prospective database. RESULTS: In the subgroup of patients with more mild hypercalcemia (Ca below 2.70mmol/L) the correlation between Ca and Cai was poor. 19 respectively 18 patients had preoperatively a Ca respectively Cai level within the reference range. Further 35 patients had preoperatively a normal level of PTH. The diagnostic sensitivities for Ca, Cai and the combination of Ca and Cai were 96%, 96% and 99%. CONCLUSION: If calcium and ionized calcium are not used in the diagnostic workup of pHPT some 4% of the patients will be overlooked. We recommend analyzing both Ca and Cai in the diagnostic workup of pHPT.}}, author = {{Nordenström, Erik and Katzman, Per and Bergenfelz, Anders}}, issn = {{1873-2933}}, language = {{eng}}, pages = {{849--852}}, publisher = {{Elsevier}}, series = {{Clinical Biochemistry}}, title = {{Biochemical diagnosis of primary hyperparathyroidism: Analysis of the sensitivity of total and ionized calcium in combination with PTH.}}, url = {{http://dx.doi.org/10.1016/j.clinbiochem.2011.04.002}}, doi = {{10.1016/j.clinbiochem.2011.04.002}}, volume = {{44}}, year = {{2011}}, }