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Phagosome dynamics during phagocytosis by neutrophils.

Nordenfelt, Pontus LU and Tapper, Hans LU (2011) In Journal of Leukocyte Biology 90. p.271-284
Abstract
The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the formation and maturation of the phagosome, is in many respects very different from that in other phagocytes. Although the complex mechanisms that coordinate the membrane traffic, oxidative burst, and release of granule contents required for the microbicidal activities of neutrophils are not completely understood, it is evident that they are unique and differ from those in macrophages. Neutrophils exhibit more rapid rates of... (More)
The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the formation and maturation of the phagosome, is in many respects very different from that in other phagocytes. Although the complex mechanisms that coordinate the membrane traffic, oxidative burst, and release of granule contents required for the microbicidal activities of neutrophils are not completely understood, it is evident that they are unique and differ from those in macrophages. Neutrophils exhibit more rapid rates of phagocytosis and higher intensity of oxidative respiratory response than do macrophages. The phagosome maturation pathway in macrophages, which is linked to the endocytic pathway, is replaced in neutrophils by the rapid delivery of preformed granules to nonacidic phagosomes. This review describes the plasticity and dynamics of the phagocytic process with a special focus on neutrophil phagosome maturation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Leukocyte Biology
volume
90
pages
271 - 284
publisher
Society for Leukocyte Biology
external identifiers
  • wos:000293338500007
  • pmid:21504950
  • scopus:79961057868
ISSN
1938-3673
DOI
10.1189/jlb.0810457
language
English
LU publication?
yes
id
6b024b65-62a8-4e5f-825c-83470f73af92 (old id 1936897)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21504950?dopt=Abstract
date added to LUP
2011-05-02 15:07:27
date last changed
2017-11-19 04:19:19
@article{6b024b65-62a8-4e5f-825c-83470f73af92,
  abstract     = {The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the formation and maturation of the phagosome, is in many respects very different from that in other phagocytes. Although the complex mechanisms that coordinate the membrane traffic, oxidative burst, and release of granule contents required for the microbicidal activities of neutrophils are not completely understood, it is evident that they are unique and differ from those in macrophages. Neutrophils exhibit more rapid rates of phagocytosis and higher intensity of oxidative respiratory response than do macrophages. The phagosome maturation pathway in macrophages, which is linked to the endocytic pathway, is replaced in neutrophils by the rapid delivery of preformed granules to nonacidic phagosomes. This review describes the plasticity and dynamics of the phagocytic process with a special focus on neutrophil phagosome maturation.},
  author       = {Nordenfelt, Pontus and Tapper, Hans},
  issn         = {1938-3673},
  language     = {eng},
  pages        = {271--284},
  publisher    = {Society for Leukocyte Biology},
  series       = {Journal of Leukocyte Biology},
  title        = {Phagosome dynamics during phagocytosis by neutrophils.},
  url          = {http://dx.doi.org/10.1189/jlb.0810457},
  volume       = {90},
  year         = {2011},
}