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Distinction of isolated tumour cells and micrometastasis in lymph nodes of breast cancer patients according to the new Tumour Node Metastasis (TNM) definitions

Cserni, Gabor; Amendoeira, Isabel; Bianchi, Simonetta; Chmielik, Ewa; DeGaetano, James; Faverly, Daniel; Figueiredo, Paulo; Foschini, Maria P.; Grabau, Dorthe LU and Jacquemier, Jocelyne, et al. (2011) In European Journal of Cancer 47(6). p.887-894
Abstract
Isolated tumour cells and micrometastases represent two different staging categories and are often dealt with differently when identified in sentinel lymph nodes of breast cancer patients. The reproducibility of these categories was found to be suboptimal in several studies. The new edition of the TNM (Tumour Node Metastasis) is expected to improve the reproducibility of these categories. Fifty cases of possible low-volume nodal involvement were represented by one to four digital images and were analysed by members of the European Working Group for Breast Screening Pathology (EWGBSP). The kappa value for interobserver agreement of the pN (TNM) staging categories and of the isolated tumour cells category were 0.55 and 0.56 reflecting... (More)
Isolated tumour cells and micrometastases represent two different staging categories and are often dealt with differently when identified in sentinel lymph nodes of breast cancer patients. The reproducibility of these categories was found to be suboptimal in several studies. The new edition of the TNM (Tumour Node Metastasis) is expected to improve the reproducibility of these categories. Fifty cases of possible low-volume nodal involvement were represented by one to four digital images and were analysed by members of the European Working Group for Breast Screening Pathology (EWGBSP). The kappa value for interobserver agreement of the pN (TNM) staging categories and of the isolated tumour cells category were 0.55 and 0.56 reflecting moderate reproducibility, and the kappa of the micrometastatic category (0.62) reflected substantial reproducibility. This is an improvement over the results gained on the basis of the previous edition of the TNM. Maximal adherence to the category definitions supplemented by explanatory texts in the staging manual should result in more homogeneous nodal staging of breast cancer. (C) 2010 Elsevier Ltd. All rights reserved. (Less)
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Contribution to journal
publication status
published
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keywords
Breast cancer, Isolated tumour cells, Isolated tumour cell cluster, Micrometastasis, Sentinel lymph node, TNM
in
European Journal of Cancer
volume
47
issue
6
pages
887 - 894
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000290056500011
  • scopus:79952985420
ISSN
1879-0852
DOI
10.1016/j.ejca.2010.11.011
language
English
LU publication?
yes
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35da292d-adaa-4446-ad70-0b1ed735eea9 (old id 1964488)
date added to LUP
2011-06-01 10:38:51
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2017-10-01 03:14:07
@article{35da292d-adaa-4446-ad70-0b1ed735eea9,
  abstract     = {Isolated tumour cells and micrometastases represent two different staging categories and are often dealt with differently when identified in sentinel lymph nodes of breast cancer patients. The reproducibility of these categories was found to be suboptimal in several studies. The new edition of the TNM (Tumour Node Metastasis) is expected to improve the reproducibility of these categories. Fifty cases of possible low-volume nodal involvement were represented by one to four digital images and were analysed by members of the European Working Group for Breast Screening Pathology (EWGBSP). The kappa value for interobserver agreement of the pN (TNM) staging categories and of the isolated tumour cells category were 0.55 and 0.56 reflecting moderate reproducibility, and the kappa of the micrometastatic category (0.62) reflected substantial reproducibility. This is an improvement over the results gained on the basis of the previous edition of the TNM. Maximal adherence to the category definitions supplemented by explanatory texts in the staging manual should result in more homogeneous nodal staging of breast cancer. (C) 2010 Elsevier Ltd. All rights reserved.},
  author       = {Cserni, Gabor and Amendoeira, Isabel and Bianchi, Simonetta and Chmielik, Ewa and DeGaetano, James and Faverly, Daniel and Figueiredo, Paulo and Foschini, Maria P. and Grabau, Dorthe and Jacquemier, Jocelyne and Kaya, Handan and Kulka, Janina and Lacerda, Manuela and Liepniece-Karele, Inta and Martinez Penuela, Jose and Quinn, Cecily and Regitnig, Peter and Reiner-Concin, Angelika and Sapino, Anna and van Diest, Paul J. and Varga, Zsuzsanna and Vezzosi, Vania and Wesseling, Jelle and Zolota, Vasiliki and Zozaya, Enrique and Wells, Clive A.},
  issn         = {1879-0852},
  keyword      = {Breast cancer,Isolated tumour cells,Isolated tumour cell cluster,Micrometastasis,Sentinel lymph node,TNM},
  language     = {eng},
  number       = {6},
  pages        = {887--894},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Distinction of isolated tumour cells and micrometastasis in lymph nodes of breast cancer patients according to the new Tumour Node Metastasis (TNM) definitions},
  url          = {http://dx.doi.org/10.1016/j.ejca.2010.11.011},
  volume       = {47},
  year         = {2011},
}