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The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL

McKeen, Hayley D.; Brennan, Donal J.; Hegarty, Shauna; Lanigan, Fiona; Jirström, Karin LU ; Byrne, Christopher; Yakkundi, Anita; McCarthy, Helen O.; Gallagher, William M. and Robson, Tracy (2011) Meeting on Signalling and Human Disease In Biochemical Society Transactions 39. p.663-668
Abstract
FKBPs (FK506-binding proteins) have long been recognized as key regulators of the response to immunosuppressant drugs and as co-chaperones of steroid receptor complexes. More recently, evidence has emerged suggesting that this diverse protein family may also represent cancer biomarkers owing to their roles in cancer progression and response to treatment. FKBPL (FKBP-like) is a novel FKBP with roles in GR (glucocorticoid receptor), AR (androgen receptor) and ER (oestrogen receptor) signalling. FKBPL binds Hsp90 (heat-shock protein 90) and modulates translocation, transcriptional activation and phosphorylation of these steroid receptors. It has been proposed as a novel prognostic and predictive biomarker, where high levels predict for... (More)
FKBPs (FK506-binding proteins) have long been recognized as key regulators of the response to immunosuppressant drugs and as co-chaperones of steroid receptor complexes. More recently, evidence has emerged suggesting that this diverse protein family may also represent cancer biomarkers owing to their roles in cancer progression and response to treatment. FKBPL (FKBP-like) is a novel FKBP with roles in GR (glucocorticoid receptor), AR (androgen receptor) and ER (oestrogen receptor) signalling. FKBPL binds Hsp90 (heat-shock protein 90) and modulates translocation, transcriptional activation and phosphorylation of these steroid receptors. It has been proposed as a novel prognostic and predictive biomarker, where high levels predict for increased recurrence-free survival in breast cancer patients and enhanced sensitivity to endocrine therapy. Since this protein family has roles in a plethora of signalling pathways, its members represent novel prognostic markers and therapeutic targets for cancer diagnosis and treatment. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
cancer biomarker, FK506-binding protein (FKBP), FK506-binding, protein-like (FKBPL), glucocorticoid receptor (GR), oestrogen, steroid, receptor
in
Biochemical Society Transactions
volume
39
pages
663 - 668
publisher
Portland Press
conference name
Meeting on Signalling and Human Disease
external identifiers
  • wos:000289958200047
  • scopus:79953188016
ISSN
0300-5127
1470-8752
DOI
10.1042/BST0390663
language
English
LU publication?
yes
id
9cc963e9-5453-4f88-b360-f939ad7e05dc (old id 1964648)
alternative location
http://www.biochemsoctrans.org/bst/039/0663/0390663.pdf
date added to LUP
2011-07-25 11:20:26
date last changed
2017-01-15 03:03:36
@inproceedings{9cc963e9-5453-4f88-b360-f939ad7e05dc,
  abstract     = {FKBPs (FK506-binding proteins) have long been recognized as key regulators of the response to immunosuppressant drugs and as co-chaperones of steroid receptor complexes. More recently, evidence has emerged suggesting that this diverse protein family may also represent cancer biomarkers owing to their roles in cancer progression and response to treatment. FKBPL (FKBP-like) is a novel FKBP with roles in GR (glucocorticoid receptor), AR (androgen receptor) and ER (oestrogen receptor) signalling. FKBPL binds Hsp90 (heat-shock protein 90) and modulates translocation, transcriptional activation and phosphorylation of these steroid receptors. It has been proposed as a novel prognostic and predictive biomarker, where high levels predict for increased recurrence-free survival in breast cancer patients and enhanced sensitivity to endocrine therapy. Since this protein family has roles in a plethora of signalling pathways, its members represent novel prognostic markers and therapeutic targets for cancer diagnosis and treatment.},
  author       = {McKeen, Hayley D. and Brennan, Donal J. and Hegarty, Shauna and Lanigan, Fiona and Jirström, Karin and Byrne, Christopher and Yakkundi, Anita and McCarthy, Helen O. and Gallagher, William M. and Robson, Tracy},
  booktitle    = {Biochemical Society Transactions},
  issn         = {0300-5127},
  keyword      = {cancer biomarker,FK506-binding protein (FKBP),FK506-binding,protein-like (FKBPL),glucocorticoid receptor (GR),oestrogen,steroid,receptor},
  language     = {eng},
  pages        = {663--668},
  publisher    = {Portland Press},
  title        = {The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL},
  url          = {http://dx.doi.org/10.1042/BST0390663},
  volume       = {39},
  year         = {2011},
}