Do risk factors for schizophrenia predispose to emigration?
(2011) In Schizophrenia Research 127(1-3). p.229-234- Abstract
- Objective: Increased incidence rates of schizophrenia in immigrants still lack a satisfactory explanation. The aim of this study was to examine the hypothesis that risk factors for schizophrenia also increase the risk of emigration to a foreign country. If valid, Danes emigrating from Denmark carry a higher predisposition to develop schizophrenia compared to Danes living in Denmark. Methods: Utilizing data from the Danish Civil Registration System, we established a population-based cohort of 1.10 million native Danes. We assessed relative risks of emigration to a foreign country in relation to sex, age, urban birth, parental age, and a history of mental illness. Results: Urban birth in Denmark was a significant predictor of emigration to a... (More)
- Objective: Increased incidence rates of schizophrenia in immigrants still lack a satisfactory explanation. The aim of this study was to examine the hypothesis that risk factors for schizophrenia also increase the risk of emigration to a foreign country. If valid, Danes emigrating from Denmark carry a higher predisposition to develop schizophrenia compared to Danes living in Denmark. Methods: Utilizing data from the Danish Civil Registration System, we established a population-based cohort of 1.10 million native Danes. We assessed relative risks of emigration to a foreign country in relation to sex, age, urban birth, parental age, and a history of mental illness. Results: Urban birth in Denmark was a significant predictor of emigration to a foreign country. A maternal history of psychiatric contact during childhood and a parental history of bipolar affective disorder increased the risks of emigration. A personal history of mental illness decreased the risk of emigration, mostly for people diagnosed with schizophrenia. Conclusions: Our study provided evidence that Danish emigrants residing in a foreign country have both a higher predisposition of schizophrenia due to differential exposure to birth in urban areas and a lower predisposition of schizophrenia due to differential exposure to a history of mental illness. Although competing selection mechanisms operate, the combined effect of these different selection mechanisms was limited, thus suggesting a potential role for yet to be identified adverse environmental effects operating either before or after emigration. (C) 2011 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1964785
- author
- Pedersen, Carsten Bocker ; Mortensen, Preben Bo and Cantor-Graae, Elizabeth LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Schizophrenia, Bipolar affective disorder, Emigration, Denmark, Epidemiology, Risk factor
- in
- Schizophrenia Research
- volume
- 127
- issue
- 1-3
- pages
- 229 - 234
- publisher
- Elsevier
- external identifiers
-
- wos:000289395100035
- scopus:79952314488
- ISSN
- 0920-9964
- DOI
- 10.1016/j.schres.2011.01.013
- language
- English
- LU publication?
- yes
- id
- 23e6127c-b8bb-4d08-8a63-b72e3997796a (old id 1964785)
- date added to LUP
- 2016-04-01 11:08:52
- date last changed
- 2022-02-18 00:32:28
@article{23e6127c-b8bb-4d08-8a63-b72e3997796a,
abstract = {{Objective: Increased incidence rates of schizophrenia in immigrants still lack a satisfactory explanation. The aim of this study was to examine the hypothesis that risk factors for schizophrenia also increase the risk of emigration to a foreign country. If valid, Danes emigrating from Denmark carry a higher predisposition to develop schizophrenia compared to Danes living in Denmark. Methods: Utilizing data from the Danish Civil Registration System, we established a population-based cohort of 1.10 million native Danes. We assessed relative risks of emigration to a foreign country in relation to sex, age, urban birth, parental age, and a history of mental illness. Results: Urban birth in Denmark was a significant predictor of emigration to a foreign country. A maternal history of psychiatric contact during childhood and a parental history of bipolar affective disorder increased the risks of emigration. A personal history of mental illness decreased the risk of emigration, mostly for people diagnosed with schizophrenia. Conclusions: Our study provided evidence that Danish emigrants residing in a foreign country have both a higher predisposition of schizophrenia due to differential exposure to birth in urban areas and a lower predisposition of schizophrenia due to differential exposure to a history of mental illness. Although competing selection mechanisms operate, the combined effect of these different selection mechanisms was limited, thus suggesting a potential role for yet to be identified adverse environmental effects operating either before or after emigration. (C) 2011 Elsevier B.V. All rights reserved.}},
author = {{Pedersen, Carsten Bocker and Mortensen, Preben Bo and Cantor-Graae, Elizabeth}},
issn = {{0920-9964}},
keywords = {{Schizophrenia; Bipolar affective disorder; Emigration; Denmark; Epidemiology; Risk factor}},
language = {{eng}},
number = {{1-3}},
pages = {{229--234}},
publisher = {{Elsevier}},
series = {{Schizophrenia Research}},
title = {{Do risk factors for schizophrenia predispose to emigration?}},
url = {{http://dx.doi.org/10.1016/j.schres.2011.01.013}},
doi = {{10.1016/j.schres.2011.01.013}},
volume = {{127}},
year = {{2011}},
}