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Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Ros, Martine M.; Bueno-de-Mesquita, H. B. Bas; Buchner, Frederike L.; Aben, Katja K. H.; Kampman, Ellen; Egevad, Lars; Overvad, Kim; Tjonneland, Anne; Roswall, Nina and Clavel-Chapelon, Francoise, et al. (2011) In International Journal of Cancer 128(11). p.2695-2708
Abstract
Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference,... (More)
Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95% CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95% CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95% CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted. (Less)
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keywords
urothelial cell carcinomas, bladder cancer, fluid, EPIC
in
International Journal of Cancer
volume
128
issue
11
pages
2695 - 2708
publisher
John Wiley & Sons
external identifiers
  • wos:000289372000020
  • scopus:79953309327
ISSN
0020-7136
DOI
10.1002/ijc.25592
language
English
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yes
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bc9ea6fa-f7b3-498a-a53f-d36cca921fdc (old id 1965643)
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2011-06-01 10:49:52
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@article{bc9ea6fa-f7b3-498a-a53f-d36cca921fdc,
  abstract     = {Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95% CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95% CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95% CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.},
  author       = {Ros, Martine M. and Bueno-de-Mesquita, H. B. Bas and Buchner, Frederike L. and Aben, Katja K. H. and Kampman, Ellen and Egevad, Lars and Overvad, Kim and Tjonneland, Anne and Roswall, Nina and Clavel-Chapelon, Francoise and Kaaks, Rudolf and Chang-Claude, Jenny and Boeing, Heiner and Weikert, Steffen and Trichopoulou, Antonia and Orfanos, Philippos and Stasinopulou, Georgia and Saieva, Calogero and Krogh, Vittorio and Vineis, Paolo and Tumino, Rosario and Mattiello, Amalia and Peeters, Petra H. M. and van Duijnhoven, Franzel J. B. and Lund, Eiliv and Gram, Inger T. and Chirlaque, Maria D. and Barricarte, Aurelio and Rodriguez, Laudina and Molina, Esther and Gonzalez, Carlos and Dorronsoro, Miren and Manjer, Jonas and Ehrnström, Roy and Ljungberg, Borje and Allen, Naomi E. and Roddam, Andrew W. and Khaw, Kay-Tee and Wareham, Nick and Boffetta, Paolo and Slimani, Nadia and Michaud, Dominique S. and Kiemeney, Lambertus A. L. M. and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {urothelial cell carcinomas,bladder cancer,fluid,EPIC},
  language     = {eng},
  number       = {11},
  pages        = {2695--2708},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1002/ijc.25592},
  volume       = {128},
  year         = {2011},
}