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Diagnostic properties of metabolic perturbations in rheumatoid arthritis

Madsen, Rasmus K.; Lundstedt, Torbjorn; Gabrielsson, Jon; Sennbro, Carl Johan LU ; Alenius, Gerd-Marie; Moritz, Thomas; Rantapaa-Dahlqvist, Solbritt and Trygg, Johan (2011) In Arthritis Research and Therapy 13(1).
Abstract
Introduction: The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. Methods: We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results: RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study... (More)
Introduction: The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. Methods: We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results: RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90% and a specificity of 94%. Glyceric acid, D-ribofuranose and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased compared with healthy controls. Conclusions: Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Research and Therapy
volume
13
issue
1
publisher
BioMed Central
external identifiers
  • wos:000289523500030
  • scopus:79551689052
ISSN
1478-6362
DOI
10.1186/ar3243
language
English
LU publication?
yes
id
ecd8df50-f4d5-4147-add7-1c91ca524c38 (old id 1966036)
date added to LUP
2011-06-01 10:51:44
date last changed
2017-10-01 03:00:21
@article{ecd8df50-f4d5-4147-add7-1c91ca524c38,
  abstract     = {Introduction: The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. Methods: We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results: RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90% and a specificity of 94%. Glyceric acid, D-ribofuranose and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased compared with healthy controls. Conclusions: Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides.},
  articleno    = {R19},
  author       = {Madsen, Rasmus K. and Lundstedt, Torbjorn and Gabrielsson, Jon and Sennbro, Carl Johan and Alenius, Gerd-Marie and Moritz, Thomas and Rantapaa-Dahlqvist, Solbritt and Trygg, Johan},
  issn         = {1478-6362},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {Diagnostic properties of metabolic perturbations in rheumatoid arthritis},
  url          = {http://dx.doi.org/10.1186/ar3243},
  volume       = {13},
  year         = {2011},
}