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Humidity affects the performance of von Frey monofilaments

Werner, M. U.; Rotboll-Nielsen, P. and Ellehuus Hilmersson, Catarina LU (2011) In Acta Anaesthesiologica Scandinavica 55(5). p.577-582
Abstract
Background Assessment of tactile and nociceptive thresholds of the skin with calibrated polyamide monofilaments is an established testing method both in animal and in human research. It is known that changes in relative humidity may affect the physical properties of the monofilaments. As this effect has only been studied in very small diameter monofilaments, used in neonatal research, we therefore studied complete sets of polyamide monofilaments. Methods The effects were studied in a controlled climate chamber during six incremental changes in relative humidity from 20% to 79% (22-24 degrees C). Following 24 h of equilibration at each humidity level, calibration with a precision scale was performed. Results A highly significant linear... (More)
Background Assessment of tactile and nociceptive thresholds of the skin with calibrated polyamide monofilaments is an established testing method both in animal and in human research. It is known that changes in relative humidity may affect the physical properties of the monofilaments. As this effect has only been studied in very small diameter monofilaments, used in neonatal research, we therefore studied complete sets of polyamide monofilaments. Methods The effects were studied in a controlled climate chamber during six incremental changes in relative humidity from 20% to 79% (22-24 degrees C). Following 24 h of equilibration at each humidity level, calibration with a precision scale was performed. Results A highly significant linear correlation between the natural logarithm (In) of the bending force and the von Frey number was observed at all humidity levels (r2 > 0.99, P < 0.0001). An inverse linear relationship between relative humidity and In of the bending force for each monofilament was found (r2=0.95, P < 0.0001). One percent increase in relative humidity corresponded to a 1-4% relative decrease in numerical bending force, depending on the diameter of the monofilament. A significant linear relationship was observed between the coefficient of variation and the relative humidity (r2=0.87, P < 0.001). Conclusions The data indicate that the hygroscopic properties of polyamide monofilaments must be taken into account for their reliable use in quantitative sensory testing. (Less)
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Contribution to journal
publication status
published
subject
in
Acta Anaesthesiologica Scandinavica
volume
55
issue
5
pages
577 - 582
publisher
Wiley-Blackwell
external identifiers
  • wos:000289365000012
  • pmid:21827443
  • scopus:79954481609
ISSN
0001-5172
DOI
10.1111/j.1399-6576.2011.02426.x
language
English
LU publication?
yes
id
b5d2905b-5495-43ba-9155-8752ad815fba (old id 1966191)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21827443?dopt=Abstract
date added to LUP
2011-06-01 10:53:12
date last changed
2017-08-27 03:11:24
@article{b5d2905b-5495-43ba-9155-8752ad815fba,
  abstract     = {Background Assessment of tactile and nociceptive thresholds of the skin with calibrated polyamide monofilaments is an established testing method both in animal and in human research. It is known that changes in relative humidity may affect the physical properties of the monofilaments. As this effect has only been studied in very small diameter monofilaments, used in neonatal research, we therefore studied complete sets of polyamide monofilaments. Methods The effects were studied in a controlled climate chamber during six incremental changes in relative humidity from 20% to 79% (22-24 degrees C). Following 24 h of equilibration at each humidity level, calibration with a precision scale was performed. Results A highly significant linear correlation between the natural logarithm (In) of the bending force and the von Frey number was observed at all humidity levels (r2 &gt; 0.99, P &lt; 0.0001). An inverse linear relationship between relative humidity and In of the bending force for each monofilament was found (r2=0.95, P &lt; 0.0001). One percent increase in relative humidity corresponded to a 1-4% relative decrease in numerical bending force, depending on the diameter of the monofilament. A significant linear relationship was observed between the coefficient of variation and the relative humidity (r2=0.87, P &lt; 0.001). Conclusions The data indicate that the hygroscopic properties of polyamide monofilaments must be taken into account for their reliable use in quantitative sensory testing.},
  author       = {Werner, M. U. and Rotboll-Nielsen, P. and Ellehuus Hilmersson, Catarina},
  issn         = {0001-5172},
  language     = {eng},
  number       = {5},
  pages        = {577--582},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Anaesthesiologica Scandinavica},
  title        = {Humidity affects the performance of von Frey monofilaments},
  url          = {http://dx.doi.org/10.1111/j.1399-6576.2011.02426.x},
  volume       = {55},
  year         = {2011},
}