The association between sleep duration, insulin sensitivity, and β-cell function : The EGIR-RISC study
(2016) In Journal of Clinical Endocrinology and Metabolism 101(9). p.3272-3280- Abstract
Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort. Design, Setting, Participants, and Measures:Weused data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer.... (More)
Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort. Design, Setting, Participants, and Measures:Weused data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer. Insulin sensitivity and β-cell function were estimated by hyperinsulinemic-euglycemic clamp and from the oral glucose insulin sensitivity index model, using an oral glucose tolerance test. Associations of sleep duration with insulin sensitivity and β-cell function were analyzed by multiple linear regression, stratified by sex. Results: In our current analysis, we included 788 participants (57% women, age 44±8 y), who had an average sleep duration of 7.3±1.5 hours. In men,weobserved an inverted U-shaped association between sleep duration categorized per hour and M/I (in μmol/min per kgFFM/nM per hour) (±- estimate [95% confidence intervals] 41 [2, 80]; P = .04 and β2-estimate -3 [-6, -0.2], P = .04) as well as a trend for the oral glucose insulin sensitivity index (in mL/min per kgFFM) (β-estimate [95% confidence intervals] 0.8 [-0.4, 2]; P = .17). In women, we observed a U-shaped association between sleep duration and β-cell function (in pmol/min perm2/mM per hour) (β-estimate-45 [-86, -3]; P = .04 and β2-estimate 3 [0.2, 6]; P = .04). Conclusions: Sleep duration is associated with insulin sensitivity and β-cell function in a sex-specific manner in clinically healthy people.
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- author
- Rutters, Femke ; Besson, Herve ; Walker, Mark ; Mari, Andrea ; Konrad, Thomas ; Nilsson, Peter M. LU ; Balkau, Beverley and Dekker, Jacqueline M.
- organization
- publishing date
- 2016-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 101
- issue
- 9
- pages
- 9 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:84988932578
- pmid:27355399
- wos:000390849100010
- ISSN
- 0021-972X
- DOI
- 10.1210/jc.2016-1045
- language
- English
- LU publication?
- yes
- id
- 196b87b3-7b9e-4893-a054-cb67e5ebbb5f
- date added to LUP
- 2016-10-28 16:32:00
- date last changed
- 2025-01-12 13:57:55
@article{196b87b3-7b9e-4893-a054-cb67e5ebbb5f,
abstract = {{<p>Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort. Design, Setting, Participants, and Measures:Weused data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer. Insulin sensitivity and β-cell function were estimated by hyperinsulinemic-euglycemic clamp and from the oral glucose insulin sensitivity index model, using an oral glucose tolerance test. Associations of sleep duration with insulin sensitivity and β-cell function were analyzed by multiple linear regression, stratified by sex. Results: In our current analysis, we included 788 participants (57% women, age 44±8 y), who had an average sleep duration of 7.3±1.5 hours. In men,weobserved an inverted U-shaped association between sleep duration categorized per hour and M/I (in μmol/min per kg<sub>FFM</sub>/nM per hour) (±- estimate [95% confidence intervals] 41 [2, 80]; P = .04 and β<sup>2</sup>-estimate -3 [-6, -0.2], P = .04) as well as a trend for the oral glucose insulin sensitivity index (in mL/min per kgFFM) (β-estimate [95% confidence intervals] 0.8 [-0.4, 2]; P = .17). In women, we observed a U-shaped association between sleep duration and β-cell function (in pmol/min perm2/mM per hour) (β-estimate-45 [-86, -3]; P = .04 and β<sup>2</sup>-estimate 3 [0.2, 6]; P = .04). Conclusions: Sleep duration is associated with insulin sensitivity and β-cell function in a sex-specific manner in clinically healthy people.</p>}},
author = {{Rutters, Femke and Besson, Herve and Walker, Mark and Mari, Andrea and Konrad, Thomas and Nilsson, Peter M. and Balkau, Beverley and Dekker, Jacqueline M.}},
issn = {{0021-972X}},
language = {{eng}},
month = {{09}},
number = {{9}},
pages = {{3272--3280}},
publisher = {{Oxford University Press}},
series = {{Journal of Clinical Endocrinology and Metabolism}},
title = {{The association between sleep duration, insulin sensitivity, and β-cell function : The EGIR-RISC study}},
url = {{http://dx.doi.org/10.1210/jc.2016-1045}},
doi = {{10.1210/jc.2016-1045}},
volume = {{101}},
year = {{2016}},
}