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The association between sleep duration, insulin sensitivity, and β-cell function : The EGIR-RISC study

Rutters, Femke ; Besson, Herve ; Walker, Mark ; Mari, Andrea ; Konrad, Thomas ; Nilsson, Peter M. LU ; Balkau, Beverley and Dekker, Jacqueline M. (2016) In Journal of Clinical Endocrinology and Metabolism 101(9). p.3272-3280
Abstract

Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort. Design, Setting, Participants, and Measures:Weused data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer.... (More)

Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort. Design, Setting, Participants, and Measures:Weused data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer. Insulin sensitivity and β-cell function were estimated by hyperinsulinemic-euglycemic clamp and from the oral glucose insulin sensitivity index model, using an oral glucose tolerance test. Associations of sleep duration with insulin sensitivity and β-cell function were analyzed by multiple linear regression, stratified by sex. Results: In our current analysis, we included 788 participants (57% women, age 44±8 y), who had an average sleep duration of 7.3±1.5 hours. In men,weobserved an inverted U-shaped association between sleep duration categorized per hour and M/I (in μmol/min per kgFFM/nM per hour) (±- estimate [95% confidence intervals] 41 [2, 80]; P = .04 and β2-estimate -3 [-6, -0.2], P = .04) as well as a trend for the oral glucose insulin sensitivity index (in mL/min per kgFFM) (β-estimate [95% confidence intervals] 0.8 [-0.4, 2]; P = .17). In women, we observed a U-shaped association between sleep duration and β-cell function (in pmol/min perm2/mM per hour) (β-estimate-45 [-86, -3]; P = .04 and β2-estimate 3 [0.2, 6]; P = .04). Conclusions: Sleep duration is associated with insulin sensitivity and β-cell function in a sex-specific manner in clinically healthy people.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Endocrinology and Metabolism
volume
101
issue
9
pages
9 pages
publisher
Oxford University Press
external identifiers
  • pmid:27355399
  • wos:000390849100010
  • scopus:84988932578
ISSN
0021-972X
DOI
10.1210/jc.2016-1045
language
English
LU publication?
yes
id
196b87b3-7b9e-4893-a054-cb67e5ebbb5f
date added to LUP
2016-10-28 16:32:00
date last changed
2022-09-07 21:26:36
@article{196b87b3-7b9e-4893-a054-cb67e5ebbb5f,
  abstract     = {{<p>Context: In the past decade, over 3 dozen studies reported a relationship between self-reported short sleep and disturbed glucose metabolism. A study with insulin sensitivity assessed according to the gold standard hyperinsulinemic-euglycemic clamp is, however, still missing. Objective: To evaluate the cross-sectional association of sleep duration with insulin sensitivity and β-cell function in the European group for the study of insulin resistance (EGIR-RISC) study cohort. Design, Setting, Participants, and Measures:Weused data from the baseline measurements of the European, multicentre EGIR-RISC study that included 1319 clinically healthy participants. Sleep and physical activity were measured using a single-axis accelerometer. Insulin sensitivity and β-cell function were estimated by hyperinsulinemic-euglycemic clamp and from the oral glucose insulin sensitivity index model, using an oral glucose tolerance test. Associations of sleep duration with insulin sensitivity and β-cell function were analyzed by multiple linear regression, stratified by sex. Results: In our current analysis, we included 788 participants (57% women, age 44±8 y), who had an average sleep duration of 7.3±1.5 hours. In men,weobserved an inverted U-shaped association between sleep duration categorized per hour and M/I (in μmol/min per kg<sub>FFM</sub>/nM per hour) (±- estimate [95% confidence intervals] 41 [2, 80]; P = .04 and β<sup>2</sup>-estimate -3 [-6, -0.2], P = .04) as well as a trend for the oral glucose insulin sensitivity index (in mL/min per kgFFM) (β-estimate [95% confidence intervals] 0.8 [-0.4, 2]; P = .17). In women, we observed a U-shaped association between sleep duration and β-cell function (in pmol/min perm2/mM per hour) (β-estimate-45 [-86, -3]; P = .04 and β<sup>2</sup>-estimate 3 [0.2, 6]; P = .04). Conclusions: Sleep duration is associated with insulin sensitivity and β-cell function in a sex-specific manner in clinically healthy people.</p>}},
  author       = {{Rutters, Femke and Besson, Herve and Walker, Mark and Mari, Andrea and Konrad, Thomas and Nilsson, Peter M. and Balkau, Beverley and Dekker, Jacqueline M.}},
  issn         = {{0021-972X}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  pages        = {{3272--3280}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Clinical Endocrinology and Metabolism}},
  title        = {{The association between sleep duration, insulin sensitivity, and β-cell function : The EGIR-RISC study}},
  url          = {{http://dx.doi.org/10.1210/jc.2016-1045}},
  doi          = {{10.1210/jc.2016-1045}},
  volume       = {{101}},
  year         = {{2016}},
}