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The role of Smad signaling in hematopoiesis and translational hematology.

Blank Savukinas, Ulrika LU and Karlsson, Stefan LU (2011) In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 25. p.1379-1388
Abstract
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Historically, HSCs are among the most thoroughly characterized tissue-specific stem cells. Despite this, the regulation of fate options, such as self-renewal and differentiation, has remained elusive, partly because of the expansive plethora of factors and signaling cues that govern HSC behavior in vivo. In the BM, HSCs are housed in specialized niches that dovetail the behavior of HSCs with the need of the organism. The Smad-signaling pathway, which operates downstream of the transforming growth factor-β (TGF-β) superfamily of ligands,... (More)
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Historically, HSCs are among the most thoroughly characterized tissue-specific stem cells. Despite this, the regulation of fate options, such as self-renewal and differentiation, has remained elusive, partly because of the expansive plethora of factors and signaling cues that govern HSC behavior in vivo. In the BM, HSCs are housed in specialized niches that dovetail the behavior of HSCs with the need of the organism. The Smad-signaling pathway, which operates downstream of the transforming growth factor-β (TGF-β) superfamily of ligands, regulates a diverse set of biological processes, including proliferation, differentiation and apoptosis, in many different organ systems. Much of the function of Smad signaling in hematopoiesis has remained nebulous due to early embryonic lethality of most knockout mouse models. However, recently new data have been uncovered, suggesting that the Smad-signaling circuitry is intimately linked to HSC regulation. In this review, we bring the Smad-signaling pathway into focus, chronicling key concepts and recent advances with respect to TGF-β-superfamily signaling in normal and leukemic hematopoiesis.Leukemia advance online publication, 13 May 2011; doi:10.1038/leu.2011.95. (Less)
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organization
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publication status
published
subject
in
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
volume
25
pages
1379 - 1388
publisher
Nature Publishing Group
external identifiers
  • wos:000294665400001
  • pmid:21566654
  • scopus:80052445124
ISSN
1476-5551
DOI
10.1038/leu.2011.95
language
English
LU publication?
yes
id
e7339746-d446-4972-93a2-ce8b93920a62 (old id 1972675)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21566654?dopt=Abstract
date added to LUP
2011-06-07 19:12:09
date last changed
2017-11-12 03:40:44
@article{e7339746-d446-4972-93a2-ce8b93920a62,
  abstract     = {Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Historically, HSCs are among the most thoroughly characterized tissue-specific stem cells. Despite this, the regulation of fate options, such as self-renewal and differentiation, has remained elusive, partly because of the expansive plethora of factors and signaling cues that govern HSC behavior in vivo. In the BM, HSCs are housed in specialized niches that dovetail the behavior of HSCs with the need of the organism. The Smad-signaling pathway, which operates downstream of the transforming growth factor-β (TGF-β) superfamily of ligands, regulates a diverse set of biological processes, including proliferation, differentiation and apoptosis, in many different organ systems. Much of the function of Smad signaling in hematopoiesis has remained nebulous due to early embryonic lethality of most knockout mouse models. However, recently new data have been uncovered, suggesting that the Smad-signaling circuitry is intimately linked to HSC regulation. In this review, we bring the Smad-signaling pathway into focus, chronicling key concepts and recent advances with respect to TGF-β-superfamily signaling in normal and leukemic hematopoiesis.Leukemia advance online publication, 13 May 2011; doi:10.1038/leu.2011.95.},
  author       = {Blank Savukinas, Ulrika and Karlsson, Stefan},
  issn         = {1476-5551},
  language     = {eng},
  pages        = {1379--1388},
  publisher    = {Nature Publishing Group},
  series       = {Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K},
  title        = {The role of Smad signaling in hematopoiesis and translational hematology.},
  url          = {http://dx.doi.org/10.1038/leu.2011.95},
  volume       = {25},
  year         = {2011},
}