Plasma homocysteine, brain imaging and cognition in older patients with mental illness.
(2012) In International Journal of Geriatric Psychiatry 27. p.409-414- Abstract
- BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in older patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. Plasma tHcy has been reported to be associated with cognitive functions. The mechanism by which plasma tHcy may influence cognitive functions is not clear. METHOD: We have investigated the relation between plasma tHcy, brain imaging findings (computer tomography scan [CT]) and cognition, measured as Mini mental state examination (MMSE), in 395 consecutively enrolled older patients with mental illness. RESULTS: Age and plasma tHcy were significant predictors of MMSE score, whereas pathological CT findings, indicating... (More)
- BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in older patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. Plasma tHcy has been reported to be associated with cognitive functions. The mechanism by which plasma tHcy may influence cognitive functions is not clear. METHOD: We have investigated the relation between plasma tHcy, brain imaging findings (computer tomography scan [CT]) and cognition, measured as Mini mental state examination (MMSE), in 395 consecutively enrolled older patients with mental illness. RESULTS: Age and plasma tHcy were significant predictors of MMSE score, whereas pathological CT findings, indicating cerebrovascular disease, showed no prediction of MMSE score. CONCLUSION: The relation between plasma tHcy and cognition is not mediated by cerebrovascular disease as evaluated by pathological CT findings. Copyright © 2011 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1972934
- author
- Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Geriatric Psychiatry
- volume
- 27
- pages
- 409 - 414
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000301228600009
- pmid:21560163
- scopus:84858337869
- pmid:21560163
- ISSN
- 1099-1166
- DOI
- 10.1002/gps.2734
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Chemistry and Pharmacology (013250300), Department of Psychogeriatrics (013304000)
- id
- b1e45899-739f-4d6a-a9ac-f3d7670821b1 (old id 1972934)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21560163?dopt=Abstract
- date added to LUP
- 2016-04-04 08:18:36
- date last changed
- 2022-05-16 21:13:32
@article{b1e45899-739f-4d6a-a9ac-f3d7670821b1, abstract = {{BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in older patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. Plasma tHcy has been reported to be associated with cognitive functions. The mechanism by which plasma tHcy may influence cognitive functions is not clear. METHOD: We have investigated the relation between plasma tHcy, brain imaging findings (computer tomography scan [CT]) and cognition, measured as Mini mental state examination (MMSE), in 395 consecutively enrolled older patients with mental illness. RESULTS: Age and plasma tHcy were significant predictors of MMSE score, whereas pathological CT findings, indicating cerebrovascular disease, showed no prediction of MMSE score. CONCLUSION: The relation between plasma tHcy and cognition is not mediated by cerebrovascular disease as evaluated by pathological CT findings. Copyright © 2011 John Wiley & Sons, Ltd.}}, author = {{Nilsson, Karin and Gustafson, Lars and Hultberg, Björn}}, issn = {{1099-1166}}, language = {{eng}}, pages = {{409--414}}, publisher = {{John Wiley & Sons Inc.}}, series = {{International Journal of Geriatric Psychiatry}}, title = {{Plasma homocysteine, brain imaging and cognition in older patients with mental illness.}}, url = {{http://dx.doi.org/10.1002/gps.2734}}, doi = {{10.1002/gps.2734}}, volume = {{27}}, year = {{2012}}, }