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Plasma homocysteine, brain imaging and cognition in older patients with mental illness.

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2012) In International Journal of Geriatric Psychiatry 27. p.409-414
Abstract
BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in older patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. Plasma tHcy has been reported to be associated with cognitive functions. The mechanism by which plasma tHcy may influence cognitive functions is not clear. METHOD: We have investigated the relation between plasma tHcy, brain imaging findings (computer tomography scan [CT]) and cognition, measured as Mini mental state examination (MMSE), in 395 consecutively enrolled older patients with mental illness. RESULTS: Age and plasma tHcy were significant predictors of MMSE score, whereas pathological CT findings, indicating... (More)
BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in older patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. Plasma tHcy has been reported to be associated with cognitive functions. The mechanism by which plasma tHcy may influence cognitive functions is not clear. METHOD: We have investigated the relation between plasma tHcy, brain imaging findings (computer tomography scan [CT]) and cognition, measured as Mini mental state examination (MMSE), in 395 consecutively enrolled older patients with mental illness. RESULTS: Age and plasma tHcy were significant predictors of MMSE score, whereas pathological CT findings, indicating cerebrovascular disease, showed no prediction of MMSE score. CONCLUSION: The relation between plasma tHcy and cognition is not mediated by cerebrovascular disease as evaluated by pathological CT findings. Copyright © 2011 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Geriatric Psychiatry
volume
27
pages
409 - 414
publisher
John Wiley and Sons Ltd
external identifiers
  • wos:000301228600009
  • pmid:21560163
  • scopus:84858337869
ISSN
1099-1166
DOI
10.1002/gps.2734
language
English
LU publication?
yes
id
b1e45899-739f-4d6a-a9ac-f3d7670821b1 (old id 1972934)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21560163?dopt=Abstract
date added to LUP
2011-06-07 15:37:16
date last changed
2017-07-02 04:34:29
@article{b1e45899-739f-4d6a-a9ac-f3d7670821b1,
  abstract     = {BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in older patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. Plasma tHcy has been reported to be associated with cognitive functions. The mechanism by which plasma tHcy may influence cognitive functions is not clear. METHOD: We have investigated the relation between plasma tHcy, brain imaging findings (computer tomography scan [CT]) and cognition, measured as Mini mental state examination (MMSE), in 395 consecutively enrolled older patients with mental illness. RESULTS: Age and plasma tHcy were significant predictors of MMSE score, whereas pathological CT findings, indicating cerebrovascular disease, showed no prediction of MMSE score. CONCLUSION: The relation between plasma tHcy and cognition is not mediated by cerebrovascular disease as evaluated by pathological CT findings. Copyright © 2011 John Wiley & Sons, Ltd.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1099-1166},
  language     = {eng},
  pages        = {409--414},
  publisher    = {John Wiley and Sons Ltd},
  series       = {International Journal of Geriatric Psychiatry},
  title        = {Plasma homocysteine, brain imaging and cognition in older patients with mental illness.},
  url          = {http://dx.doi.org/10.1002/gps.2734},
  volume       = {27},
  year         = {2012},
}