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An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes.

Lindvall, Therese LU ; Kutty Selva, Nandakumar LU ; Yousefi, Kimia ; Holmdahl, Rikard LU and Andersson, Åsa (2011) In Journal of Neuroimmunology 235(1-2). p.40-47
Abstract
A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4(+) T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroimmunology
volume
235
issue
1-2
pages
40 - 47
publisher
Elsevier
external identifiers
  • wos:000292665000006
  • pmid:21543122
  • scopus:79958019186
  • pmid:21543122
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2011.04.001
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
id
b1aad4ad-b1a0-40db-9c1f-1c3b8a10f887 (old id 1973165)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21543122?dopt=Abstract
date added to LUP
2016-04-01 09:48:01
date last changed
2021-08-04 01:35:13
@article{b1aad4ad-b1a0-40db-9c1f-1c3b8a10f887,
  abstract     = {A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4(+) T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules.},
  author       = {Lindvall, Therese and Kutty Selva, Nandakumar and Yousefi, Kimia and Holmdahl, Rikard and Andersson, Åsa},
  issn         = {1872-8421},
  language     = {eng},
  number       = {1-2},
  pages        = {40--47},
  publisher    = {Elsevier},
  series       = {Journal of Neuroimmunology},
  title        = {An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes.},
  url          = {http://dx.doi.org/10.1016/j.jneuroim.2011.04.001},
  doi          = {10.1016/j.jneuroim.2011.04.001},
  volume       = {235},
  year         = {2011},
}