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Quality of life and toxicity in breast cancer patients using adjuvant TAC (docetaxel, doxorubicin, cyclophosphamide), in comparison with FAC (doxorubicin, cyclophosphamide, 5-fluorouracil).

Hatam, Nahid; Ahmadloo, Niloofar; Ahmad Kiadaliri, Aliasghar LU and Bastani, Peivand (2011) In Archives of Gynecology and Obstetrics 284(1). p.215-220
Abstract (Swedish)
Abstract in Undetermined

The aim of this study was to compare two regimens of chemotherapy in patients with breast cancer, including FAC (doxorubicin, cyclophosphamide, and 5-fluorouracil) and TAC (docetaxel, doxorubicin and cyclophosphamide); and analyze the toxicity of these treatments and observe patient's health-related quality of life.



Health-related quality of life was assessed for up to 4 months (from the beginning to the end of chemotherapy cycles), using European organization and cancer treatment quality of life questionnaire (EORTC) QLQ-C30. A group of 100 patients, with node-positive breast cancer were studied in order to compare the toxicity of adjuvant therapy TAC with FAC and the subsequent... (More)
Abstract in Undetermined

The aim of this study was to compare two regimens of chemotherapy in patients with breast cancer, including FAC (doxorubicin, cyclophosphamide, and 5-fluorouracil) and TAC (docetaxel, doxorubicin and cyclophosphamide); and analyze the toxicity of these treatments and observe patient's health-related quality of life.



Health-related quality of life was assessed for up to 4 months (from the beginning to the end of chemotherapy cycles), using European organization and cancer treatment quality of life questionnaire (EORTC) QLQ-C30. A group of 100 patients, with node-positive breast cancer were studied in order to compare the toxicity of adjuvant therapy TAC with FAC and the subsequent effects on the patient's quality of life.



After a 4-month follow-up of patients, our findings showed that despite having the same mean score of QOL at the start of adjuvant chemotherapy, the QOL in TAC arm was decreased more as a result of the higher range of toxicity in TAC regimen.



In spite of increase in disease-free patients who received TAC regimen and increase their survival rate, there is significant toxicity and decrease in QOL in TAC protocol compare to FAC protocol. Using prophylactic granulocyte colony stimulating factor (G-CSF) along with increased education aimed at improving patient's knowledge and also the provision of a supportive group involving psychiatrics and patients that have successfully experienced the same treatment may be helpful. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adjuvant therapy, Toxicity, Quality of life, Breast cancer
in
Archives of Gynecology and Obstetrics
volume
284
issue
1
pages
215 - 220
publisher
Springer
external identifiers
  • wos:000291482900033
  • scopus:79958791086
ISSN
1432-0711
DOI
10.1007/s00404-010-1609-8
language
English
LU publication?
yes
id
0d92c882-edaf-4ce4-a7a2-7aade00fa65a (old id 1982690)
date added to LUP
2012-01-18 16:11:01
date last changed
2017-07-30 03:04:30
@article{0d92c882-edaf-4ce4-a7a2-7aade00fa65a,
  abstract     = {<b>Abstract in Undetermined</b><br/><br>
The aim of this study was to compare two regimens of chemotherapy in patients with breast cancer, including FAC (doxorubicin, cyclophosphamide, and 5-fluorouracil) and TAC (docetaxel, doxorubicin and cyclophosphamide); and analyze the toxicity of these treatments and observe patient's health-related quality of life.<br/><br>
<br/><br>
Health-related quality of life was assessed for up to 4 months (from the beginning to the end of chemotherapy cycles), using European organization and cancer treatment quality of life questionnaire (EORTC) QLQ-C30. A group of 100 patients, with node-positive breast cancer were studied in order to compare the toxicity of adjuvant therapy TAC with FAC and the subsequent effects on the patient's quality of life.<br/><br>
<br/><br>
After a 4-month follow-up of patients, our findings showed that despite having the same mean score of QOL at the start of adjuvant chemotherapy, the QOL in TAC arm was decreased more as a result of the higher range of toxicity in TAC regimen.<br/><br>
<br/><br>
In spite of increase in disease-free patients who received TAC regimen and increase their survival rate, there is significant toxicity and decrease in QOL in TAC protocol compare to FAC protocol. Using prophylactic granulocyte colony stimulating factor (G-CSF) along with increased education aimed at improving patient's knowledge and also the provision of a supportive group involving psychiatrics and patients that have successfully experienced the same treatment may be helpful.},
  author       = {Hatam, Nahid and Ahmadloo, Niloofar and Ahmad Kiadaliri, Aliasghar and Bastani, Peivand},
  issn         = {1432-0711},
  keyword      = {Adjuvant therapy,Toxicity,Quality of life,Breast cancer},
  language     = {eng},
  number       = {1},
  pages        = {215--220},
  publisher    = {Springer},
  series       = {Archives of Gynecology and Obstetrics},
  title        = {Quality of life and toxicity in breast cancer patients using adjuvant TAC (docetaxel, doxorubicin, cyclophosphamide), in comparison with FAC (doxorubicin, cyclophosphamide, 5-fluorouracil).},
  url          = {http://dx.doi.org/10.1007/s00404-010-1609-8},
  volume       = {284},
  year         = {2011},
}