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Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men

Tajar, Abdelouahid; McBeth, John; Lee, David M.; Macfarlane, Gary J.; Huhtaniemi, Ilpo T.; Finn, Joseph D.; Bartfai, Gyorgy; Boonen, Steven; Casanueva, Felipe F. and Forti, Gianni, et al. (2011) In Pain 152(7). p.1495-1501
Abstract
The aim of this study was to determine the association of hormone levels with the occurrence of musculoskeletal pain. Men ages 40 to 79 years were recruited from population registers in 8 European centres. Subjects were asked to complete a postal questionnaire, which enquired about lifestyle and the occurrence of musculoskeletal pain over the past month. Total testosterone (T), oestradiol (E2), luteinising hormone (LH), and follicle-stimulating hormone (FSH) were assayed from a fasting blood sample. The association between pain status and hormone levels was assessed using multinomial logistic regression with results expressed as relative risk ratios (RRR) and 95% confidence intervals (CI). A total of 3206 men had complete data on pain... (More)
The aim of this study was to determine the association of hormone levels with the occurrence of musculoskeletal pain. Men ages 40 to 79 years were recruited from population registers in 8 European centres. Subjects were asked to complete a postal questionnaire, which enquired about lifestyle and the occurrence of musculoskeletal pain over the past month. Total testosterone (T), oestradiol (E2), luteinising hormone (LH), and follicle-stimulating hormone (FSH) were assayed from a fasting blood sample. The association between pain status and hormone levels was assessed using multinomial logistic regression with results expressed as relative risk ratios (RRR) and 95% confidence intervals (CI). A total of 3206 men had complete data on pain status. Of these, 8.7% reported chronic widespread pain (CWP), whereas 50% had some pain although not CWP and were classified as having some pain. T and E2 were not associated with musculoskeletal pain, whereas significant differences in LH and FSH levels were found between pain groups. After adjustment for age and other possible confounders, the association between pain status and both LH and FSH persisted. Compared with those in the lowest tertile of LH, those in the highest tertile were more likely to report some pain (vs no pain, RRR = 1.28; 95% CI 1.09 to 1.50) and also CWP (vs no pain, RRR = 1.51; 95% CI 1.10 to 2.07). Similar results were found for FSH. Gonadotrophins, but not sex steroid hormone levels, are associated with musculoskeletal pain in men. (C) 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. (Less)
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keywords
Musculoskeletal pain, Reproductive hormones, American College of, Rheumatology, European Male Ageing Study, Epidemiology
in
Pain
volume
152
issue
7
pages
1495 - 1501
publisher
Elsevier
external identifiers
  • wos:000291474000012
  • scopus:79958714448
ISSN
1872-6623
DOI
10.1016/j.pain.2011.01.048
language
English
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yes
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476ec605-4f74-4d53-8cb4-ba5168c3a724 (old id 1984765)
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2011-07-01 09:13:05
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@article{476ec605-4f74-4d53-8cb4-ba5168c3a724,
  abstract     = {The aim of this study was to determine the association of hormone levels with the occurrence of musculoskeletal pain. Men ages 40 to 79 years were recruited from population registers in 8 European centres. Subjects were asked to complete a postal questionnaire, which enquired about lifestyle and the occurrence of musculoskeletal pain over the past month. Total testosterone (T), oestradiol (E2), luteinising hormone (LH), and follicle-stimulating hormone (FSH) were assayed from a fasting blood sample. The association between pain status and hormone levels was assessed using multinomial logistic regression with results expressed as relative risk ratios (RRR) and 95% confidence intervals (CI). A total of 3206 men had complete data on pain status. Of these, 8.7% reported chronic widespread pain (CWP), whereas 50% had some pain although not CWP and were classified as having some pain. T and E2 were not associated with musculoskeletal pain, whereas significant differences in LH and FSH levels were found between pain groups. After adjustment for age and other possible confounders, the association between pain status and both LH and FSH persisted. Compared with those in the lowest tertile of LH, those in the highest tertile were more likely to report some pain (vs no pain, RRR = 1.28; 95% CI 1.09 to 1.50) and also CWP (vs no pain, RRR = 1.51; 95% CI 1.10 to 2.07). Similar results were found for FSH. Gonadotrophins, but not sex steroid hormone levels, are associated with musculoskeletal pain in men. (C) 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.},
  author       = {Tajar, Abdelouahid and McBeth, John and Lee, David M. and Macfarlane, Gary J. and Huhtaniemi, Ilpo T. and Finn, Joseph D. and Bartfai, Gyorgy and Boonen, Steven and Casanueva, Felipe F. and Forti, Gianni and Giwercman, Aleksander and Han, Thang S. and Kula, Krzysztof and Labrie, Fernand and Lean, Michael E. J. and Pendleton, Neil and Punab, Margus and Silman, Alan J. and Vanderschueren, Dirk and O'Neill, Terence W. and Wud, Frederick C. W.},
  issn         = {1872-6623},
  keyword      = {Musculoskeletal pain,Reproductive hormones,American College of,Rheumatology,European Male Ageing Study,Epidemiology},
  language     = {eng},
  number       = {7},
  pages        = {1495--1501},
  publisher    = {Elsevier},
  series       = {Pain},
  title        = {Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men},
  url          = {http://dx.doi.org/10.1016/j.pain.2011.01.048},
  volume       = {152},
  year         = {2011},
}