N-terminal pro-atrial natriuretic peptide response to acute exercise in depressed patients and healthy controls
(2011) In Psychoneuroendocrinology 36(5). p.656-663- Abstract
- Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acute exercise compared to healthy controls. Secondly, we aimed to assess the effect of antidepressants on NT-proANP response to acute exercise. Methods: We examined 132 outpatients with mild to moderate depression (ICD-10) and 44 healthy controls, group matched for age, sex, and BMI. We used an incremental bicycle ergometer test as a physical... (More)
- Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acute exercise compared to healthy controls. Secondly, we aimed to assess the effect of antidepressants on NT-proANP response to acute exercise. Methods: We examined 132 outpatients with mild to moderate depression (ICD-10) and 44 healthy controls, group matched for age, sex, and BMI. We used an incremental bicycle ergometer test as a physical stressor. Blood samples were drawn at rest, at exhaustion, and 15, 30, and 60 min post-exercise. Results: The NT-proANP response to physical exercise differed between depressed subjects and healthy controls (group x time; F-4,F-162.9 = 10.92; p < 0.001). The increase from rest to VO2max was 0.98 (SD 0.8) and 1.96 nmol/l (SD 1.1), respectively, for depressed subjects and healthy controls (mean diff: 0.98 nmol/l; 95% CI 0.7-1.3; t = 6.63; df = 170; p < 0.001). The increase in NT-proANP from rest to peak VO2max was 1.27 (SD 1.0) and 0.84 nmol/l (SD 0.6), respectively, for unmedicated and medicated patients (mean diff: 0.42 nmol/l; 95% CI 0.1-0.8; t = 2.56; df = 128; p = 0.01). Conclusion: We observed an attenuated NT-proANP response to acute physical stress in depressed patients. Antidepressants were associated with an independent suppressive effect on the NT-proANP response. (c) 2010 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1985154
- author
- Krogh, Jesper ; Stroehle, Andreas ; Westrin, Åsa LU ; Klausen, Tobias ; Jorgensen, Martin Balslev and Nordentoft, Merete
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Natriuretic peptides, Atrial natriuretic peptide, Depression, Exercise, test, SSRI, SNRI
- in
- Psychoneuroendocrinology
- volume
- 36
- issue
- 5
- pages
- 656 - 663
- publisher
- Elsevier
- external identifiers
-
- wos:000291190400006
- scopus:79955521686
- ISSN
- 1873-3360
- DOI
- 10.1016/j.psyneuen.2010.09.009
- language
- English
- LU publication?
- yes
- id
- 2cd27a71-98cd-4724-a7cc-843e269db463 (old id 1985154)
- date added to LUP
- 2016-04-01 10:28:52
- date last changed
- 2022-01-25 23:42:57
@article{2cd27a71-98cd-4724-a7cc-843e269db463, abstract = {{Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acute exercise compared to healthy controls. Secondly, we aimed to assess the effect of antidepressants on NT-proANP response to acute exercise. Methods: We examined 132 outpatients with mild to moderate depression (ICD-10) and 44 healthy controls, group matched for age, sex, and BMI. We used an incremental bicycle ergometer test as a physical stressor. Blood samples were drawn at rest, at exhaustion, and 15, 30, and 60 min post-exercise. Results: The NT-proANP response to physical exercise differed between depressed subjects and healthy controls (group x time; F-4,F-162.9 = 10.92; p < 0.001). The increase from rest to VO2max was 0.98 (SD 0.8) and 1.96 nmol/l (SD 1.1), respectively, for depressed subjects and healthy controls (mean diff: 0.98 nmol/l; 95% CI 0.7-1.3; t = 6.63; df = 170; p < 0.001). The increase in NT-proANP from rest to peak VO2max was 1.27 (SD 1.0) and 0.84 nmol/l (SD 0.6), respectively, for unmedicated and medicated patients (mean diff: 0.42 nmol/l; 95% CI 0.1-0.8; t = 2.56; df = 128; p = 0.01). Conclusion: We observed an attenuated NT-proANP response to acute physical stress in depressed patients. Antidepressants were associated with an independent suppressive effect on the NT-proANP response. (c) 2010 Elsevier Ltd. All rights reserved.}}, author = {{Krogh, Jesper and Stroehle, Andreas and Westrin, Åsa and Klausen, Tobias and Jorgensen, Martin Balslev and Nordentoft, Merete}}, issn = {{1873-3360}}, keywords = {{Natriuretic peptides; Atrial natriuretic peptide; Depression; Exercise; test; SSRI; SNRI}}, language = {{eng}}, number = {{5}}, pages = {{656--663}}, publisher = {{Elsevier}}, series = {{Psychoneuroendocrinology}}, title = {{N-terminal pro-atrial natriuretic peptide response to acute exercise in depressed patients and healthy controls}}, url = {{http://dx.doi.org/10.1016/j.psyneuen.2010.09.009}}, doi = {{10.1016/j.psyneuen.2010.09.009}}, volume = {{36}}, year = {{2011}}, }