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N-terminal pro-atrial natriuretic peptide response to acute exercise in depressed patients and healthy controls

Krogh, Jesper; Stroehle, Andreas; Westrin, Åsa LU ; Klausen, Tobias; Jorgensen, Martin Balslev and Nordentoft, Merete (2011) In Psychoneuroendocrinology 36(5). p.656-663
Abstract
Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acute exercise compared to healthy controls. Secondly, we aimed to assess the effect of antidepressants on NT-proANP response to acute exercise. Methods: We examined 132 outpatients with mild to moderate depression (ICD-10) and 44 healthy controls, group matched for age, sex, and BMI. We used an incremental bicycle ergometer test as a physical... (More)
Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acute exercise compared to healthy controls. Secondly, we aimed to assess the effect of antidepressants on NT-proANP response to acute exercise. Methods: We examined 132 outpatients with mild to moderate depression (ICD-10) and 44 healthy controls, group matched for age, sex, and BMI. We used an incremental bicycle ergometer test as a physical stressor. Blood samples were drawn at rest, at exhaustion, and 15, 30, and 60 min post-exercise. Results: The NT-proANP response to physical exercise differed between depressed subjects and healthy controls (group x time; F-4,F-162.9 = 10.92; p < 0.001). The increase from rest to VO2max was 0.98 (SD 0.8) and 1.96 nmol/l (SD 1.1), respectively, for depressed subjects and healthy controls (mean diff: 0.98 nmol/l; 95% CI 0.7-1.3; t = 6.63; df = 170; p < 0.001). The increase in NT-proANP from rest to peak VO2max was 1.27 (SD 1.0) and 0.84 nmol/l (SD 0.6), respectively, for unmedicated and medicated patients (mean diff: 0.42 nmol/l; 95% CI 0.1-0.8; t = 2.56; df = 128; p = 0.01). Conclusion: We observed an attenuated NT-proANP response to acute physical stress in depressed patients. Antidepressants were associated with an independent suppressive effect on the NT-proANP response. (c) 2010 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Natriuretic peptides, Atrial natriuretic peptide, Depression, Exercise, test, SSRI, SNRI
in
Psychoneuroendocrinology
volume
36
issue
5
pages
656 - 663
publisher
Elsevier
external identifiers
  • wos:000291190400006
  • scopus:79955521686
ISSN
1873-3360
DOI
10.1016/j.psyneuen.2010.09.009
language
English
LU publication?
yes
id
2cd27a71-98cd-4724-a7cc-843e269db463 (old id 1985154)
date added to LUP
2011-07-01 09:07:17
date last changed
2017-01-01 03:37:58
@article{2cd27a71-98cd-4724-a7cc-843e269db463,
  abstract     = {Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acute exercise compared to healthy controls. Secondly, we aimed to assess the effect of antidepressants on NT-proANP response to acute exercise. Methods: We examined 132 outpatients with mild to moderate depression (ICD-10) and 44 healthy controls, group matched for age, sex, and BMI. We used an incremental bicycle ergometer test as a physical stressor. Blood samples were drawn at rest, at exhaustion, and 15, 30, and 60 min post-exercise. Results: The NT-proANP response to physical exercise differed between depressed subjects and healthy controls (group x time; F-4,F-162.9 = 10.92; p &lt; 0.001). The increase from rest to VO2max was 0.98 (SD 0.8) and 1.96 nmol/l (SD 1.1), respectively, for depressed subjects and healthy controls (mean diff: 0.98 nmol/l; 95% CI 0.7-1.3; t = 6.63; df = 170; p &lt; 0.001). The increase in NT-proANP from rest to peak VO2max was 1.27 (SD 1.0) and 0.84 nmol/l (SD 0.6), respectively, for unmedicated and medicated patients (mean diff: 0.42 nmol/l; 95% CI 0.1-0.8; t = 2.56; df = 128; p = 0.01). Conclusion: We observed an attenuated NT-proANP response to acute physical stress in depressed patients. Antidepressants were associated with an independent suppressive effect on the NT-proANP response. (c) 2010 Elsevier Ltd. All rights reserved.},
  author       = {Krogh, Jesper and Stroehle, Andreas and Westrin, Åsa and Klausen, Tobias and Jorgensen, Martin Balslev and Nordentoft, Merete},
  issn         = {1873-3360},
  keyword      = {Natriuretic peptides,Atrial natriuretic peptide,Depression,Exercise,test,SSRI,SNRI},
  language     = {eng},
  number       = {5},
  pages        = {656--663},
  publisher    = {Elsevier},
  series       = {Psychoneuroendocrinology},
  title        = {N-terminal pro-atrial natriuretic peptide response to acute exercise in depressed patients and healthy controls},
  url          = {http://dx.doi.org/10.1016/j.psyneuen.2010.09.009},
  volume       = {36},
  year         = {2011},
}