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Developments for a growing Japanese patient population: Facilitating new technologies for future health care

Kato, Harubumi; Nishimura, Toshihide; Ikeda, Norihiko; Yamada, Tesshi; Kondo, Tadashi; Saijo, Nagahiro; Nishio, Kazuto; Fujimoto, Junichiro; Nomura, Masaharu and Oda, Yoshiya, et al. (2011) In Journal of Proteomics 74(6). p.759-764
Abstract
Lung cancer, COPD and cardiovascular diseases are highlighted as some of the most common disease that cause mortality, and for that reason are the most active areas for drug development. This perspective paper overviews the urgent need to develop a health care system for a rapidly growing patient population in Japan, including forthcoming demands on clinical care, expecting outcomes, and economics. There is an increasing requirement to build on the strengths of the current health care system, thereby delivering urgent solutions for the future. There is also a declaration from the Ministry of Health, Labour and Welfare (MHLW), to develop new biomarker diagnostics, which is intended for patient stratification, aiding in diagnostic phenotype... (More)
Lung cancer, COPD and cardiovascular diseases are highlighted as some of the most common disease that cause mortality, and for that reason are the most active areas for drug development. This perspective paper overviews the urgent need to develop a health care system for a rapidly growing patient population in Japan, including forthcoming demands on clinical care, expecting outcomes, and economics. There is an increasing requirement to build on the strengths of the current health care system, thereby delivering urgent solutions for the future. There is also a declaration from the Ministry of Health, Labour and Welfare (MHLW), to develop new biomarker diagnostics, which is intended for patient stratification, aiding in diagnostic phenotype selection for responders to drug treatment of Japanese patients. This perspective was written by the panel in order to introduce novel technologies and diagnostic capabilities with successful implementation. The next generation of personalized drugs for targeted and stratified patient treatment will soon be available in major disease areas such as, lifestyle-related cancers, especially lung cancers with the highest mortality including a predisposing disorder chronic obstructive pulmonary disease, cardiovascular disease, and other diseases. Mass spectrometric technologies can provide the "phenotypic fingerprint" required for the concept of Personalized Medicine. Mass spectrometry-driven target biomarker diagnoses in combination with high resolution computed tomography can provide a critical pathway initiative facilitated by a fully integrated e-Health infrastructure system. We strongly recommend integrating validated biomarkers based on clinical proteomics, medical imaging with clinical care supported by e-Health model to support personalized treatment paradigms to reduce mortality and healthcare costs of chronic and co-morbid diseases in the elderly population of Japan. (C) 2011 Published by Elsevier B.V. (Less)
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published
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keywords
Lung cancer, Chronic Obstructive Pulmonary, Disease, Proteomics, Biomarker, Mass spectrometry, Diagnosis
in
Journal of Proteomics
volume
74
issue
6
pages
759 - 764
publisher
Elsevier
external identifiers
  • wos:000291287800001
  • scopus:79955474695
ISSN
1874-3919
DOI
10.1016/j.jprot.2010.12.006
language
English
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yes
id
e5f147a3-4fe2-4d39-93e2-1b3cc792ef68 (old id 1985380)
date added to LUP
2011-06-29 14:02:27
date last changed
2017-09-03 03:29:42
@article{e5f147a3-4fe2-4d39-93e2-1b3cc792ef68,
  abstract     = {Lung cancer, COPD and cardiovascular diseases are highlighted as some of the most common disease that cause mortality, and for that reason are the most active areas for drug development. This perspective paper overviews the urgent need to develop a health care system for a rapidly growing patient population in Japan, including forthcoming demands on clinical care, expecting outcomes, and economics. There is an increasing requirement to build on the strengths of the current health care system, thereby delivering urgent solutions for the future. There is also a declaration from the Ministry of Health, Labour and Welfare (MHLW), to develop new biomarker diagnostics, which is intended for patient stratification, aiding in diagnostic phenotype selection for responders to drug treatment of Japanese patients. This perspective was written by the panel in order to introduce novel technologies and diagnostic capabilities with successful implementation. The next generation of personalized drugs for targeted and stratified patient treatment will soon be available in major disease areas such as, lifestyle-related cancers, especially lung cancers with the highest mortality including a predisposing disorder chronic obstructive pulmonary disease, cardiovascular disease, and other diseases. Mass spectrometric technologies can provide the "phenotypic fingerprint" required for the concept of Personalized Medicine. Mass spectrometry-driven target biomarker diagnoses in combination with high resolution computed tomography can provide a critical pathway initiative facilitated by a fully integrated e-Health infrastructure system. We strongly recommend integrating validated biomarkers based on clinical proteomics, medical imaging with clinical care supported by e-Health model to support personalized treatment paradigms to reduce mortality and healthcare costs of chronic and co-morbid diseases in the elderly population of Japan. (C) 2011 Published by Elsevier B.V.},
  author       = {Kato, Harubumi and Nishimura, Toshihide and Ikeda, Norihiko and Yamada, Tesshi and Kondo, Tadashi and Saijo, Nagahiro and Nishio, Kazuto and Fujimoto, Junichiro and Nomura, Masaharu and Oda, Yoshiya and Lindmark, Bertil and Maniwa, Jiro and Hibino, Hitoshi and Unno, Michiaki and Ito, Toshinori and Sawa, Yoshiki and Tojo, Hiromasa and Egawa, Shin and Edula, Goutham and Lopez, Mary and Wigmore, Murray and Inase, Naohiko and Yoshizawa, Yasuyuki and Nomura, Fumio and Marko-Varga, György},
  issn         = {1874-3919},
  keyword      = {Lung cancer,Chronic Obstructive Pulmonary,Disease,Proteomics,Biomarker,Mass spectrometry,Diagnosis},
  language     = {eng},
  number       = {6},
  pages        = {759--764},
  publisher    = {Elsevier},
  series       = {Journal of Proteomics},
  title        = {Developments for a growing Japanese patient population: Facilitating new technologies for future health care},
  url          = {http://dx.doi.org/10.1016/j.jprot.2010.12.006},
  volume       = {74},
  year         = {2011},
}